Abstract：
BACKGROUND:The aim of this study was to detect the prognostic significance of survivin level and the expression of total p53 in acute lymphoblastic leukemia (ALL) and its correlation to patients' outcome. METHODS:Sixty two children newly diagnosed with acute lymphoblastic leukemia were treated with chemotherapy and followed up for 2 years or until death. Twenty apparently healthy volunteers with matched age and sex were taken as control. Survivin protein was measured by quantitative sandwich enzyme immunoassay and total human p53 was measured by Flow cytometry in peripheral blood at diagnosis and at complete remission. RESULTS:A highly significant elevation (P<0.0001) was found in survivin protein and total p53 levels in acute lymphoblastic leukemia children patients at diagnosis compared to controls. At complete remission a significant decrease of the two indices were found in ALL patients compared to those at diagnosis (P<0.0001). Survivin protein and total p53 was significantly higher in non-survived compared to survived group (P<0.0001 & P=0.016, respectively). A positive correlation was found between survivin level and total human p53 level in children with ALL (r=0.501 & P<0.0001). CCONCLUSION: survivin protein is related to anti-apoptotic proteins and its high expression lead to unsuccessful treatment of ALL. Survivin and TP53 are new prognostic tools in ALL, independent of age and sex.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Yahya RS,Fouda MI,El-Baz HA,Mosa TE,Elmaksoud MDsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
37-44issue
1eissn
2251-6085issn
2251-6093journal_volume
41pub_type
杂志文章abstract：BACKGROUND:Cigarette smoking is the largest preventable cause of death worldwide. No systematic review is available on the situation of the smoking in Iran, so we decided to provide an overview of the studies in the field of smoking in Iranian populations. METHODS:Published Persian-language papers of all types until 2...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Much of the environment is affected by petroleum contamination. It imposes serious health problems for humans as well as serious environmental impact. Bioremediation is an important consideration for removing environmental pollutants because, compared with other technologies, it incurrs lower costs and is en...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Research background approved weight loss would result in improvement of lipid profile. Nowadays, weight management is attained by modifying psychological mediators, as well as dieting and making individuals do more physical activity. Hence, This research was performed to compare effectiveness of different ps...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：Background:Pseudoexfoliation syndrome (XFS) is pathogenetically related to exfoliative glaucoma (XFG), which is the most common type of secondary glaucoma. We aimed to investigate the relationship between LOXL1 SNPs (rs1048661, rs3825942) and XFS and/or XFG in a cohort of Iranian subjects. Methods:This cross-sectional...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-10-01 00:00:00
abstract：Background:We aimed to investigate the expressions of miR-21 and miR-210 in the breast cancer tissue and their correlation with clinicopathological features and prognosis. Methods:A retrospective analysis was performed on 68 patients with breast cancer treated surgically in Wuhan General Hospital of Guangzhou Military...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Chinese medical workers suffer from a high incidence of mental health problems, resulting in reduced efficiency, increased medical malpractice, rising medical costs, and other issues. The effective alleviation of mental health problems among medical workers is therefore an important focus of research and soc...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Neural tube defects (NTD) are one of the leading causes of infant mortality worldwide. This study was designed to determine the prevalence of NTDs among native Fars ethnic groups during 1998-2005, and to identify maternal and demographic factors associated with NTDs. METHODS:We performed a descriptive cross...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was identification of the epidemiology of Prototheca zopfii species from the milk samples of dairy cattle in Isfahan, central Iran. METHODS:Milk samples were obtained from 230 dairy cattle, 130 with and 100 without mastitis, in Isfahan. The samples were cultured in Prototheca Isolation...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:The Ministry of Health and Medical Education of Iran, along with the country movement towards achievements of Iran's Vision 2025 put compilation of the health system reform plan on its agenda. In this article, we are trying to show the method we used for developing this plan and how this method considered th...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Performance is a multi-dimensional and dynamic concept. During the past 2 decades, considerable studies were performed in developing the hospital performance concept. To know literature key concepts on hospital performance, the knowledge visualization based on co-word analysis and social network analysis has...
journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
doi：
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Residents play an important role in the delivery of hospital care. They regularly work overnight, in emergency situations and with workload and stress which can affect their performance and quality of working life (QWL). This study explores the QWL and its contributory factors in residents working at hospita...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：Background:The recognition of patient safety is now occupying a prominent place on the health policy agenda since medical errors can result in adverse events. The existence of confusing drug names is one of the most common causes of medication errors. In Iran, the General Office of Trademarks Registry (GOTR), for four ...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2017-12-01 00:00:00
abstract：Background:Korean traditional nuruk, consisting of a variety of microorganisms, is widely used in traditional liquor materials. The present study evaluated the antimicrobial activity of strains isolated from Korean traditional nuruk in 2016. Methods:The strain was isolated from Korea traditional nuruk and performed an...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Anaerobic treatment methods are more suitable for the treatment of concentrated wastewater streams, offer lower operating costs, the production of usable biogas product. The aim of this study was to investigate the performance of an Anaerobic Fluidized Bed Reactor (AFBR)-Aerobic Moving Bed Bio Reactor (MBBR)...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
abstract：Background:This population-based study aimed at investigating the prevalence and associated factors of over-weight /obesity and abdominal obesity in Iran. Methods:The study population consists of 2818 inhabitant of the urban and regional area of East-Azerbaijan, Iran in 2015. The weight, height and waist circumference...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Rotaviruses cause diarrhea in infants and young children worldwide. Rotavirus outer capsid protein, VP7 is major neutralizing antigen that is important component of subunit vaccine to prevent rotavirus infection. Many efforts have been done to produce recombinant VP7 that maintain native characteristics. We ...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Noise pollution is one of the most harmful ambiance disturbances. It may cause many deficits in ability and activity of persons in the urban and industrial areas. It also may cause many kinds of psychopathies. Therefore, it is very important to measure the risk of this pollution in different area. METHODS:T...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to evaluate the capability of helminths to absorb heavy metals in comparison with that of the host tissues. METHODS:We compared the concentration of cadmium (Cd) and chromium (Cr) in urban rats and in their harboring helminthes -Moniliformis moniliformis, Hymenolepis diminut...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：Background:The aim of this study was assessment of the chronic effects of sulfur mustard (SM) among victims. Methods:In this cohort study, 355 SM-exposed subjects from Sardasht, and 123 controls from Rabat, both from West Azerbaijan Province, Iran were included. The spirometric evaluation and the global initiative for...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：:Chromosome aberration is associated with infertility and isochromosome is a rare chromosomal abnormality potentially associated with infertility or multiple miscarriages. Here we report a man of 29-yr-old diagnosed of infertility from China with rare isochromosome. Peripheral blood lymphocytes were obtained for chromo...
journal_title：Iranian journal of public health
pub_type：
doi：
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:An explosion of research has been done in discovering how human health is affected by environmental factors. I will discuss the impacts of environmental cancer causing factors and how they continue to cause multiple disruptions in cellular networking. Some risk factors may not cause cancer. Other factors ini...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:This study conducted to examine and to provide a systematic literature over the influence of adolescents' physical activity (PA) in maximizing`s peak bone mass (PBM). PBM or the 'bone bank' is an important determinant in achieving healthy bone. PA is one of the bone's lifestyle contributors and high PBM is o...
journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
abstract：Background:We aimed to determine the level of computer game addiction and loneliness among 9-10-yr-old children. Methods:The study was conducted with 4th-grade students at a primary school, located at the city center, during 2017-2018 academic years. There was no sampling in the research, all 4th-grade students of the...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2018-10-01 00:00:00
abstract：:In September 2007 national standard manual was finalized and officially announced as the minimal quality requirements for all medical laboratories in the country. Apart from auditing laboratories, Reference Health Laboratory has performed benchmarking auditing of medical laboratory network (surveys) in provinces. 12(t...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：Background:This study investigated how experiencing school violence affects depression and suicidal ideation in multicultural adolescents. Methods:Overall, 63444 adolescents from grades 7-12 (ages 12-18 yr) who participated in the 11th Korea Youth Risk Behavior Web-based Survey (KYRBS-XI) were enrolled from Jun 1 to J...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-02-01 00:00:00
abstract：Background:Non-standard management of medical waste leads to irreparable side effects. This issue is of double importance in health care centers in a city which are the most extensive system for providing Primary Health Care (PHC) across Iran cities. This study investigated the medical waste management standards observ...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:This study aimed to determine the prevalence of hearing impairment (HI) by age and gender in a population aged 5 yr and older residing in Tehran, Iran. METHODS:In this cross-sectional study, 140 clusters each including 10 households from Tehran, Iran were sampled between 2012 and 2013 using cluster random s...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
abstract：Background:Suicide/suicide attempt, as a major public health problem, has been included among anti-social behaviors. We aimed to investigate the epidemiology of suicide and some associated individual, family, and social factors. Methods:A historical cohort study was conducted among all cases (748 persons) reports rela...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
abstract：Background:Cefepime-resistant Escherichia coli (E. coli) is one of the seven important types of microbial resistance. This meta-analysis study was conducted to identify the prevalence of cefepime-resistant E. coli in Iran during 2007-2016. Methods:Studies published were searched in Persian databases (including Magiran...
journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
doi：
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:This study aimed to analysis the inequalities of mortality of children under 5 years in West Africa by examining the determinants and contributing factors to the overall inequality concentration in these countries. METHOD:Data used came from the DHS surveys conducted in the six countries in West Africa: Bur...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
