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Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders.

Abstract：

:Since endothelial cells can be targeted by large contrast-carrying particles, molecular imaging of cerebrovascular cell activation is highly promising to evaluate the underlying inflammation of the central nervous system (CNS). In this study, we aimed to demonstrate that molecular magnetic resonance imaging (MRI) of cerebrovascular cell activation can reveal CNS disorders in the absence of visible lesions and symptoms. To this aim, we optimized contrast carrying particles targeting vascular cell adhesion molecule-1 and MRI protocols through both in vitro and in vivo experiments. Although, pre-contrast MRI images failed to reveal the ongoing pathology, contrast-enhanced MRI revealed hypoperfusion-triggered CNS injury in vascular dementia, unmasked amyloid-induced cerebrovascular activation in Alzheimer's disease and allowed monitoring of disease activity during experimental autoimmune encephalomyelitis. Moreover, contrast-enhanced MRI revealed the cerebrovascular cell activation associated with known risk factors of CNS disorders such as peripheral inflammation, ethanol consumption, hyperglycemia and aging. By providing a dramatically higher sensitivity than previously reported methods and molecular contrast agents, the technology described in the present study opens new avenues of investigation in the field of neuroinflammation.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Montagne A,Gauberti M,Macrez R,Jullienne A,Briens A,Raynaud JS,Louin G,Buisson A,Haelewyn B,Docagne F,Defer G,Vivien D,Maubert E

doi

10.1016/j.neuroimage.2012.07.018

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

760-70

issue

2

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(12)00728-8

journal_volume

63

pub_type

杂志文章

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