The ATF6 branch of unfolded protein response and apoptosis are activated to promote African swine fever virus infection.

abstract：:Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood. The purpose of current study was to investigate the role of Mas receptor in lipid-induced kidney injury. In mice fed with high-fat diet (HFD), the protein abu...

journal_title：Cell death & disease

authors： Kong Y,Zhao X,Qiu M,Lin Y,Feng P,Li S,Liang B,Zhu Q,Huang H,Li C,Wang W

更新日期：2021-01-21 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments as these cells play critical roles in tumor progression and frequently antagonize the response to treatments. TAMs are usually associated to an M2-like phenotype, characterized by anti-inflammatory and protumoral properties. This...

journal_title：Cell death & disease

authors： Genard G,Wera AC,Huart C,Le Calve B,Penninckx S,Fattaccioli A,Tabarrant T,Demazy C,Ninane N,Heuskin AC,Lucas S,Michiels C

更新日期：2018-06-27 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is an important mitotic kinase and its expression is tightly regulated in the cell cycle and in the DNA damage response. PLK1 expression is previously shown to be suppressed by p53 and/or p21. Here, we demonstrate that the CCAAT box in the PLK1 promoter is pivotal for p53/p21-mediated PLK1 re...

journal_title：Cell death & disease

authors： Lin YC,Chen YN,Lin KF,Wang FF,Chou TY,Chen MY

更新日期：2014-01-09 00:00:00

abstract：:The clinical use of the antineoplastic drug cisplatin is limited by its deleterious nephrotoxic side effect. Cisplatin-induced nephrotoxicity is associated with an increase in oxidative stress, leading ultimately to renal cell death and irreversible kidney dysfunction. Oxidative stress could be modified by the cystic ...

journal_title：Cell death & disease

authors： Rubera I,Duranton C,Melis N,Cougnon M,Mograbi B,Tauc M

更新日期：2013-10-03 00:00:00

abstract：:Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...

journal_title：Cell death & disease

authors： Narayanan SP,Xu Z,Putluri N,Sreekumar A,Lemtalsi T,Caldwell RW,Caldwell RB

更新日期：2014-02-20 00:00:00

abstract：:Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence...

journal_title：Cell death & disease

authors： Zhong J,Wang H,Chen W,Sun Z,Chen J,Xu Y,Weng M,Shi Q,Ma D,Miao C

更新日期：2017-05-04 00:00:00

abstract：:Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (meso3 CAR, also known...

journal_title：Cell death & disease

authors： Zhang Z,Jiang D,Yang H,He Z,Liu X,Qin W,Li L,Wang C,Li Y,Li H,Xu H,Jin H,Qian Q

更新日期：2019-06-17 00:00:00

abstract：:Paracetamol (acetaminophen, APAP) is a universally used analgesic and antipyretic agent. Considered safe at therapeutic doses, overdoses cause acute liver damage characterized by centrilobular hepatic necrosis. One of the major clinical problems of paracetamol-induced liver disease is the development of hemorrhagic al...

journal_title：Cell death & disease

authors： Badmann A,Langsch S,Keogh A,Brunner T,Kaufmann T,Corazza N

更新日期：2012-12-20 00:00:00

abstract：:Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated...

journal_title：Cell death & disease

authors： Hou S,Tian T,Qi D,Sun K,Yuan Q,Wang Z,Qin Z,Wu Z,Chen Z,Zhang J

更新日期：2018-02-15 00:00:00

abstract：:Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of cancer stem cell (CSC) markers, and high ALDH1 expression has been related to drug resistance and facilitated tumor growth. In this study, we investigated the potential involvement of nuclear factor erythroid 2-like 2 (NFE2L2/NRF2) in CSC-like properties of ALDH-high ovar...

journal_title：Cell death & disease

authors： Kim D,Choi BH,Ryoo IG,Kwak MK

更新日期：2018-08-30 00:00:00

abstract：:Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development. The senescence program is realized through autocrin...

journal_title：Cell death & disease

authors： Severino V,Alessio N,Farina A,Sandomenico A,Cipollaro M,Peluso G,Galderisi U,Chambery A

更新日期：2013-11-07 00:00:00

abstract：:Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first ...

journal_title：Cell death & disease

authors： Bessa C,Soares J,Raimundo L,Loureiro JB,Gomes C,Reis F,Soares ML,Santos D,Dureja C,Chaudhuri SR,Lopez-Haber C,Kazanietz MG,Gonçalves J,Simões MF,Rijo P,Saraiva L

更新日期：2018-01-18 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most common malignancy of the biliary tract characterized by its high chemoresistant tendency. Although great progresses have been made in recent decades for treating many cancers with anticancer drugs, effective therapeutics methods for anti-GBC are still lacking. Therefore, inv...

journal_title：Cell death & disease

authors： Wang H,Zhan M,Xu SW,Chen W,Long MM,Shi YH,Liu Q,Mohan M,Wang J

更新日期：2017-05-11 00:00:00

abstract：:Macrophages are involved in tumor growth and progression. They infiltrate into tumors and cause inflammation, which creates a microenvironment favoring tumor growth and metastasis. However, certain stimuli may induce macrophages to act as tumor terminators. Here we report that the calcineurin B subunit (CnB) synergize...

journal_title：Cell death & disease

authors： Su Z,Yang R,Zhang W,Xu L,Zhong Y,Yin Y,Cen J,DeWitt JP,Wei Q

更新日期：2015-05-07 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic (DA) neurons in the substantia nigra (SN); however, the underlying molecular mechanisms remain to be fully elucidated. In this study, we found that the expression level of transcription factor Six...

journal_title：Cell death & disease

authors： Gao J,Kang XY,Sun S,Li L,Zhang BL,Li YQ,Gao DS

更新日期：2016-05-05 00:00:00

abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

journal_title：Cell death & disease

authors： Mun GI,Choi E,Lee Y,Lee YS

更新日期：2020-05-26 00:00:00

abstract：:Spermidine, a natural polyamine presented widely in mammalian cells, has been implicated to extend the lifespan of several model organisms by inducing autophagy. However, the effect of spermidine against neuronal damage has not yet been fully determined. In this study, neuronal cell injury was induced by treating PC12...

journal_title：Cell death & disease

authors： Yang Y,Chen S,Zhang Y,Lin X,Song Y,Xue Z,Qian H,Wang S,Wan G,Zheng X,Zhang L

更新日期：2017-04-06 00:00:00

abstract：:Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed CRC cell proliferat...

journal_title：Cell death & disease

authors： Guo X,Zhu Y,Hong X,Zhang M,Qiu X,Wang Z,Qi Z,Hong X

更新日期：2017-07-27 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...

journal_title：Cell death & disease

authors： Goto K,Tong KI,Ikura J,Okada H

更新日期：2011-12-01 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...

journal_title：Cell death & disease

authors： Shen X,Xu F,Li M,Wu S,Zhang J,Wang A,Xu L,Liu Y,Zhu G

更新日期：2020-10-22 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00

abstract：:Global cerebral ischemia/reperfusion (I/R) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. But the mechanisms have remained uncharacterized. Protein S-nitrosylation and denitrosylation is an important reversible posttranslational modification, which is a common mechanism in signal tra...

journal_title：Cell death & disease

authors： Sun N,Hao JR,Li XY,Yin XH,Zong YY,Zhang GY,Gao C

更新日期：2013-08-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest and apoptosis in hum...

journal_title：Cell death & disease

authors： Liao YJ,Bai HY,Li ZH,Zou J,Chen JW,Zheng F,Zhang JX,Mai SJ,Zeng MS,Sun HD,Pu JX,Xie D

更新日期：2014-03-20 00:00:00

abstract：:Following stroke-induced neuronal damage, quiescent oligodendrocyte precursors (OPCs) are activated to proliferate and later to differentiate to myelin-producing cells. GPR17, a receptor transiently expressed on early OPCs, has emerged as a target to implement stroke repair through stimulation of OPC maturation. Howev...

journal_title：Cell death & disease

authors： Bonfanti E,Gelosa P,Fumagalli M,Dimou L,Viganò F,Tremoli E,Cimino M,Sironi L,Abbracchio MP

更新日期：2017-06-08 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by Lewy body formation and progressive dopaminergic neuron death in the substantia nigra (SN). Genetic susceptibility is a strong risk factor for PD. Previously, a rare gain-of-function variant of GLUD2 glutamate dehydrogenase (T1492G) was re...

journal_title：Cell death & disease

authors： Zhang W,Gong J,Ding L,Zhang Z,Pan X,Chen X,Guo W,Zhang X,Yang X,Peng G,Lin Y,Gao F,Li Y,Zhu X,Xuan A,Wang S,Sun X,Zhang Y,Xu P

更新日期：2020-10-22 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+CD33lowCD11bdim MDSCs in the periphe...

journal_title：Cell death & disease

authors： Mao FY,Zhao YL,Lv YP,Teng YS,Kong H,Liu YG,Wu XL,Hao CJ,Chen W,Duan MB,Han B,Ma Q,Wang TT,Peng LS,Zhang JY,Cheng P,Su CY,Fu XL,Zou QM,Guo G,Guo XL,Zhuang Y

更新日期：2018-07-09 00:00:00

abstract：:Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, un...

journal_title：Cell death & disease

authors： Ali A,Zhang P,Liangfang Y,Wenshe S,Wang H,Lin X,Dai Y,Feng XH,Moses R,Wang D,Li X,Xiao J

更新日期：2015-03-12 00:00:00

abstract：:The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic differentiation of marrow-derived mesenchymal stem cells (MSCs) from AS patients in a two-dimensional culture...

journal_title：Cell death & disease

authors： Zheng G,Xie Z,Wang P,Li J,Li M,Cen S,Tang S,Liu W,Ye G,Li Y,Wang S,Wu X,Su H,Wu Y,Shen H

更新日期：2019-04-25 00:00:00