Abstract：
OBJECTIVE:A retrospective observational study was done to describe the clinical and pathological profile of gastrointestinal stromal tumors (GISTs) in Afro-Caribbean patients at a tertiary care referral center over a 5-year period. RESULTS:Eighteen cases of GIST were identified over the period under review. Male to female ratio was 1.25:1, the mean age was 54.7 years, and abdominal pain (44%) and gastrointestinal bleeding (50%) were the predominant presenting symptoms. The majority of tumors were of gastric location (83%) and spindle cell morphology (66%). C-kit (CD117) positivity was found in 13 of 14 (93%) cases tested. Using current guidelines for assigning risk of aggressive behavior, 44% of tumors were considered high risk. Of the 10 patients with high-risk or intermediate-risk tumors, 4 died, 1 of which had developed resistance to imatinib therapy. CONCLUSION:In this group of patients, GISTs demonstrated predominantly gastric location and spindle cell morphology and a guarded outlook for more aggressive tumors, which is moderated in the long-term by imatinib resistance.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Brady-West D,Blake Gdoi
10.1016/s0027-9684(15)30122-xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
72-7issue
1-2eissn
0027-9684issn
1943-4693pii
S0027-9684(15)30122-Xjournal_volume
104pub_type
杂志文章abstract：:A comprehensive family practice clerkship program at Howard University College of Medicine has been conducted since 1970. This institution is one of three predominantly black institutions offering a family practice program. The senior clerkship is mandatory and at least 20 to 25 percent of each class elect to particip...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：OBJECTIVES:To assess the prevalence of vitamin D deficiency among patients in an inner-city practice with a large African American population, and to evaluate the efficacy of vitamin D replacement as part of routine care. METHODS:A chart review was undertaken to identify patients aged 18 years and more with at least o...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30337-0
更新日期：2011-05-01 00:00:00
abstract：:Painful palmar and plantar erythema is an uncommon systemic complication of chemotherapy and has been reported in association with methotrexate, cystosine arabinoside, doxorubicin, and 5-fluorouracil. The authors report a case in which the syndrome was precipitated by hepatic artery infusion of 5-FUdR. The previous re...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:Colorectal cancer causes significant morbidity and mortality in the United States. African Americans are disproportionately affected by this malignancy. There is evidence to suggest that resident physicians inconsistently screen for colorectal cancer in African Americans, perhaps because of a deficiency in knowledge a...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:African Americans have higher rates of hypertension and poorer health status than their white counterparts. This study assessed the relationship between health status, cardiovascular risk factors, and measured blood pressure. Free blood pressure screenings were performed at businesses and organizations located in west...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:A rare case of primary melanoma of the cervix is reported. The patient presented with vaginal bleeding and was thought to have a degenerated cervical fibroid. A radical hysterectomy with pelvic node dissection was performed and followed postoperatively with chemotherapy (phenylalanine mustard). The patient died within...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to characterize African-American women attending a community clinic who report frequent douching (douching > or = 2 times per week). METHODS:A consecutive sample of 115 black women attending a community clinic were interviewed face-to-face about their douching practices. Logistic...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:The achievements of 19th century medical education, practice, literature, and science and their affect on 20th century medicine are reviewed. The contributions made by 19th century physicians to change medical education are described, as well as the social processes that influenced medicine and science in both centuri...
journal_title：Journal of the National Medical Association
pub_type： 历史文章,杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：BACKGROUND:Racial and ethnic minorities are underrepresented in the health professions. Affirmative action and educational pipeline programs play a vital role in increasing the diversity of health professions, addressing educational opportunity gaps, and reducing health disparities. Part 1 of this 2-part series discuss...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/s0027-9684(15)31030-0
更新日期：2009-09-01 00:00:00
abstract：:Precocious puberty can be very confusing and frightening to an affected child and his or her family. The following presentation includes the pertinent physiology, psychology, etiology, diagnosis, and treatment of precocious pubertal development. Radioimmunoassays for gonadotropins and several key hormones are now avai...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：:This article reviews diagnosis and management of infants with diabetes. These infants present with signs and symptoms confused with other more common illnesses in this age group. A physician examining an ill-appearing dehydrated infant, without any obvious cause for the dehydration, should quickly screen the urine for...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1991-04-01 00:00:00
abstract：:More than 250 cases of Cornelia de Lange syndrome have been reported in the medical literature, but not have described the use of hip reconstruction to correct the congenital dysplasia that may be associated with this condition. This article reports the application of a bipolar hemiarthroplasty and acetabular allograf...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：:A 75-year-old woman with two previous neck operations for follicular carcinoma of the thyroid presented with a breast mass nine years after diagnosis. The mass recurred one month after excisional biopsy. Pathological examination revealed metastatic follicular carcinoma. The breast tumor was weakly positive for estroge...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：:A 64-year-old man got trismus and trigeminal neuralgia under the diagnosis of colon cancer with mandibular metastasis after emergency appendectomy and elective hemicolectomy. The patient chose to forgo further surgery and was given only palliative chemotherapy and radiotherapy. He died six months after diagnosis. Meta...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31353-5
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:This article highlights issues of misdiagnosis in an African-American, adult clinical population by doing point prevalence, record review study within a comprehensive community mental health center. METHOD:Psychiatric evaluations of 330 patients were reviewed and clinically identifiable variables of: a) childh...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/S0027-9684(15)30048-1
更新日期：2015-03-01 00:00:00
abstract：:This article reports the results of clinical testing in pediatric patients of a new contrast agent, gadoteridol injection (ProHance), developed by Squibb Diagnostic as a nonionic gadolinium agent for use in magnetic resonance imaging (MRI). Thirteen children (four girls and nine boys) ranging in age from 10 to 18 year...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:A left testicular mass was found in a 34-year-old black man with a history of multisystem sarcoidosis of 7½ years duration. Microscopic examination of the excised testicle revealed noncaseating granulomas throughout, as well as a few such lesions in the epididymis. This is the seventh reported, microscopically proven ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Splenomegaly, when present as a manifestation of sarcoidosis, may cause pressure symptoms and hypersplenism. Literature reports of giant splenomegaly are few in number and describe the use of aggressive intervention with systemic steroids and splenectomy. However, the natural history of splenic sarcoidosis is not well...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：:Peritoneal lavage fluid for cytologic study was obtained in 73 patients undergoing primary surgery for stage I endometrial adenocarcinoma. Preoperative irradiation was not used. Malignant cells consistent with endometrial adenocarcinoma were present in eight (11 percent) cases. There was no significant difference in t...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：BACKGROUND:Racial/ethnic difference in bone mineral density (BMD) exists. The underlying mechanism is unclear and needs investigation. PURPOSE:To determine BMD and its relation to environmental exposure in recent African immigrants. METHODS:BMD in recent sub-Saharan Sudanese immigrants (55 men and 88 premenopausal wo...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:Early detection of pregnancy offers many advantages for the fetus and the mother. Many medical benefits depend on early detection, including social and emotional well-being and the aviodance of medicationss, irradiation, and other teratogencis. In the past, women became aware of their pregnancies only when organogen...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:Nigeria is one of the ten countries with the highest tuberculosis (TB) burden globally and is experiencing an increasing incidence of drug resistance. This study aimed to determine the prevalence of mycobacterium tuberculosis and rifampicin resistance (DR-TB) among patients screened at the TB clinic of a ter...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2017.04.007
更新日期：2018-02-01 00:00:00
abstract：:A pilot study was conducted in anticipation of implementation of a larger project to assess human immunodeficiency virus (HIV) risk behaviors among older African Americans. A cross-sectional methodology was employed, including 33 African Americans aged more than 50 years in the metropolitan Washington, DC, area. The a...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30291-1
更新日期：2011-03-01 00:00:00
abstract：:Forty-two patients with renal cell carcinoma were evaluated with computerized tomography (CT) followed by surgical exploration, extirpative surgery, or autopsy to determine the accuracy of the CT scan in assessing the extension of the disease. There was an overall accuracy of 95 percent (40/42 patients). The two stagi...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:The rare association of protease inhibitor deficiency (Pi(zz) genotype) in a black American with chronic, obstructive pulmonary disease due to asthmatic bronchitis, rather than basal pan lobular emphysema, is presented. The late onset of symptoms, despite environmental exposures, is also unusual in this homozygote, as...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1978-02-01 00:00:00
abstract：:Prehospital delay is an important cause of out-of-hospital coronary mortality. To determine the effects of decision time delay in a patient population comprised mainly of blacks and the underprivileged, 74 consecutive patients with acute chest pain necessitating admission to the coronary care unit in a large urban hos...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Many Native American tribes use acanthosis nigricans to screen for type 2 diabetes risk. We hypothesized that acanthosis nigricans misses many children at risk for type 2 diabetes. METHODS:We evaluated 5- to 18-year-old Native American children and youth to assess the sensitivity and specificity of acanthos...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30714-8
更新日期：2010-10-01 00:00:00
abstract：:The surgeon who is faced with the management of a neonate with a prenatally ruptured omphalocele or a gastroschisis has a challenging problem. These anomalles are some of the most serious, lifethreatening neonatal surgical emergencies. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:Advances in heart failure treatment have not necessarily translated into equity in improved outcomes for African Americans. Heart failure in African Americans is characterized by a higher prevalence, especially at younger ages; more-adverse course with more frequent hospitalizations; and higher mortality rates compare...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30257-1
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Although several studies have outlined the need for and benefits of diversity in academia, the number of underrepresented minority (URM) faculty in academic health centers remains low, and minority faculty are primarily concentrated at the rank of assistant professor. In order to increase the diversity of th...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
