Looking to the future: incorporating genomic information into disparities research to reduce measurement error and selection bias.

Abstract:

OBJECTIVE:To extend recent conceptual and methodological advances in disparities research to include the incorporation of genomic information in analyses of racial/ethnic disparities in health care and health outcomes. DATA SOURCES:Published literature on human genetic variation, the role of genetics in disease and response to treatment, and methodological developments in disparities research. STUDY DESIGN:We present a conceptual framework for incorporating genomic information into the Institute of Medicine definition of racial/ethnic disparities in health care, identify key concepts used in disparities research that can be informed by genomics research, and illustrate the incorporation of genomic information into current methods using the example of HER-2 mutations guiding care for breast cancer. PRINCIPAL FINDINGS:Genomic information has not yet been incorporated into disparities research, though it has direct relevance to concepts of race/ethnicity, health status, appropriate care, and socioeconomic status. The HER-2 example demonstrates how available genetic information can be incorporated into current disparities methods to reduce selection bias and measurement error. Advances in health information infrastructure may soon make standardized genetic information more available to health services researchers. CONCLUSION:Genomic information can refine measurement of racial/ethnic disparities in health care and health outcomes and should be included wherever possible in disparities research.

journal_name

Health Serv Res

journal_title

Health services research

authors

Shields AE,Crown WH

doi

10.1111/j.1475-6773.2012.01413.x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

1387-410

issue

3 Pt 2

eissn

0017-9124

issn

1475-6773

journal_volume

47

pub_type

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