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Modification of altered ankle motor control after stroke using focal application of botulinum toxin type A.

Abstract：

STUDY DESIGN:Blinded, placebo-controlled, prospective clinical trial. PURPOSE:To examine the effects of botulinum toxin type A (BTX-A) injections into plantar flexor muscles in stroke patients with equinovarus gait. SUBJECTS:15 post-stroke and 10 matched neurologically intact subjects. METHODS:Modified Ashworth Scale (MAS) and Fugl-Meyer assessment of physical function scale scores along with surface EMG collected before and up to 12 weeks after BTX-A injections to plantar flexor muscle motor points in stroke subjects. Saline placebo injections were performed in a subset of stroke subject group. RESULTS:MAS scores were decreased at 4, 8 and 12 weeks but F-M scores did not improve until 12 weeks post injection. Multi-muscle EMG patterns showed the return of volitional dorsiflexor activity in 11 and a decrease of antagonistic and distant coactivation in all but one of the 15. CONCLUSIONS:BTX-A is effective in reducing antagonistic and distant muscle activation that impedes volitional dorsiflexion.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Tang SF,Hong JP,McKay WB,Tang CW,Wu PH,Chu NK

doi

10.1016/j.clineuro.2012.03.014

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

498-501

issue

5

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(12)00166-7

journal_volume

114

pub_type

杂志文章,随机对照试验

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