当前位置： SCI文献检索 > JOURNAL OF CLINICAL PERIODONTOLOGY期刊下所有文献 > Regenerative therapy of infrabony defects with or without systemic doxycycline. A randomized placebo-controlled trial.

Regenerative therapy of infrabony defects with or without systemic doxycycline. A randomized placebo-controlled trial.

Abstract：

AIM:Comparison of regenerative therapy of infrabony defects with and without administration of postsurgical systemic doxycycline (DOXY). METHODS:In each of 61 patients one infrabony defect was treated with enamel matrix derivative (EMD), EMD plus filler or membrane at two centres. By random assignment patients received either 200 mg DOXY per day or placebo (PLAC) for 7 days after surgery. Prior to and 6 months after surgery probing pocket depths (PPD) and vertical attachment level (PAL-V) were obtained. RESULTS:Fifty-four patients (DOXY: 27; PLAC: 27) were re-examined after 6 months and had been treated exclusively with EMD. Seven to 8 days after surgery 81% of defects in both groups showed complete flap closure. In both groups significant (p < 0.001) PPD reduction (DOXY: 3.87 ± 1.44 mm; PLAC: 3.67 ± 1.30 mm) and PAL-V gain (DOXY: 3.11 ± 1.50 mm; PLAC: 3.32 ± 1.83 mm) were observed. However, the differences failed to be statistically significant (PPD: 0.20; p = 0.588; PAL-V: 0.21; p = 0.657). CONCLUSIONS:Two hundred milligram systemic DOXY administered for 7 days after therapy of infrabony defects with EMD failed to result in better PPD reduction and PAL-V gain compared with PLAC which may be due to low power (50%) and, thus, random chance.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Röllke L,Schacher B,Wohlfeil M,Kim TS,Kaltschmitt J,Krieger J,Krigar DM,Reitmeir P,Eickholz P

doi

10.1111/j.1600-051X.2012.01861.x

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

448-56

issue

5

eissn

0303-6979

issn

1600-051X

journal_volume

39

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF CLINICAL PERIODONTOLOGY文献大全
  • Analysis of periodontal risk profiles in adults with or without a history of myocardial infarction.

    abstract：BACKGROUND:An association between periodontitis and cardiovascular diseases has been suggested. AIMS:To study whether a combination of clinical variables in a functional risk diagram enhanced the ability to differentiate between subjects with or without an immediate history of acute myocardial infarction (AMI). MATER...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.0303-6979.2004.00431.x

    authors： Renvert S,Ohlsson O,Persson S,Lang NP,Persson GR

    更新日期：2004-01-01 00:00:00

  • Soft tissue myxoma: report of an unusual case located on the gingiva.

    abstract：BACKGROUND:Soft tissue myxoma of the oral cavity is rare. Only three cases of myxoma of gingiva have been reported in the literature. We present a case of soft tissue myxoma arising from the left maxillary adherent gingiva in a 42-year-old male [correction of female] patient. METHODS:Histological examination showed sp...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2005.00837.x

    authors： Perrotti V,Rubini C,Fioroni M,Piattelli A

    更新日期：2006-01-01 00:00:00

  • Clinical effects of root instrumentation using conventional steel or non-tooth substance removing plastic curettes during supportive periodontal therapy (SPT).

    abstract：:Although root instrumentation has been accepted as the most important cause-related treatment of periodontal diseases, repeated scaling and root planing may over time result in substantive loss of tooth substance and increased sensitivity of the teeth. In an effort to minimize these side effects of therapy, non-root s...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1034/j.1600-051x.1999.t01-6-261101.x

    authors： Bardet P,Suvan J,Lang NP

    更新日期：1999-11-01 00:00:00

  • Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells.

    abstract：BACKGROUND AND AIMS:Periodontitis is an infection with an episodic nature of tissue support destruction. The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells in periodontal sites characterized by active periodontal connectiv...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2007.01190.x

    authors： Silva N,Dutzan N,Hernandez M,Dezerega A,Rivera O,Aguillon JC,Aravena O,Lastres P,Pozo P,Vernal R,Gamonal J

    更新日期：2008-03-01 00:00:00

  • Laser application in non-surgical periodontal therapy: a systematic review.

    abstract：OBJECTIVES:The primary aim was to address the following focused question: What is the clinical effect of laser application compared with mechanical debridement in non-surgical periodontal therapy in patients with chronic periodontitis? A secondary aim was to survey the relevant literature in relation to safety of laser...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/j.1600-051X.2008.01259.x

    authors： Schwarz F,Aoki A,Becker J,Sculean A

    更新日期：2008-09-01 00:00:00

  • A "case control" study on the rôle of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO).

    abstract：:HLA DR4 antigens have been considered as a risk factor in periodontal disease. The aim of this "case control" study was to verify and to provide fuller clarification of such data. "Cases" or patients had to be aged between 20 and 48 years. They presented at least 5 sites spread over several teeth with an attachment lo...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.1999.260203.x

    authors： Bonfil JJ,Dillier FL,Mercier P,Reviron D,Foti B,Sambuc R,Brodeur JM,Sedarat C

    更新日期：1999-02-01 00:00:00

  • A biomechanical assessment of the relation between the oral implant stability at insertion and subjective bone quality assessment.

    abstract：AIM:The study was set to evaluate the validity of subjective jaw bone quality assessment. MATERIALS AND METHODS:A total of 298 patients (198 females, mean age 56.4) were treated with oral implants at the Periodontology Department at the University Hospital of KUL. A total of 761 TiUnite implants have been installed. S...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2007.01047.x

    authors： Alsaadi G,Quirynen M,Michiels K,Jacobs R,van Steenberghe D

    更新日期：2007-04-01 00:00:00

  • Mandibular and maxillary furcation tunnel preparations--literature review and a case report.

    abstract：AIM:The objective of this literature review and subsequent case report is to discuss and illustrate the tunnel preparation procedure as a treatment alternative for furcation-involved molars. REVIEW OF THE LITERATURE:Furcation tunnel preparation, i.e., the creation of access for plaque control between periodontally dis...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,评审

    doi：

    authors： Rüdiger SG

    更新日期：2001-01-01 00:00:00

  • Evidence grade associating periodontitis with preterm birth and/or low birth weight: II: a systematic review of randomized trials evaluating the effects of periodontal treatment.

    abstract：AIM:The aim of this systematic review was to evaluate whether maternal periodontal disease treatment (MPDT) can reduce the incidence of preterm birth (PB) and/or low birth weight (LBW). METHODS:The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched for entries up to October 2010 without r...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/j.1600-051X.2011.01761.x

    authors： Chambrone L,Pannuti CM,Guglielmetti MR,Chambrone LA

    更新日期：2011-10-01 00:00:00

  • Self-reported questionnaire for surveillance of periodontitis in Chinese patients from a prosthodontic clinic: a validation study.

    abstract：BACKGROUND AND PURPOSE:Periodontal maintenance is critical for the long-term success of prosthodontic treatment. This study investigates the validity of questionnaires/models in monitoring periodontitis for Chinese prosthodontic patients. METHODS:In total, 114 patients completed the questionnaire. The chi-squared test...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12103

    authors： Wu X,Weng H,Lin X

    更新日期：2013-06-01 00:00:00

  • Comparison of the plaque removal efficacy of a new flossing aid (Quik Floss) to finger flossing.

    abstract：:The purpose of this clinical trial was to compare the effectiveness and safety of a new dental flossing device (Quik Floss) to finger flossing in plaque removal, reduction of gingival inflammation and patient preference. 30 healthy, non-flossing adults with 20 natural teeth, a plaque index (PI) of at least 1.8 and a g...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1600-051x.1996.tb00626.x

    authors： Carter-Hanson C,Gadbury-Amyot C,Killoy W

    更新日期：1996-09-01 00:00:00

  • Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients.

    abstract：:The aim of the present study was to characterize the eventual presence and molecular forms of gelatinase/type IV collagenase activities in gingival crevicular fluid (GCF) and saliva in different forms of periodontitis; patients with clinically healthy periodontium served as controls. Enzyme activities were monitored e...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1994.tb00272.x

    authors： Ingman T,Sorsa T,Lindy O,Koski H,Konttinen YT

    更新日期：1994-01-01 00:00:00

  • Resolution of bone defects of varying dimension and configuration in the marginal portion of the peri-implant bone. An experimental study in the dog.

    abstract：BACKGROUND:It was demonstrated that a marginal defect of about 1 mm between the bone wall and the metal surface after implant installation can heal with a high degree of bone fill and osseointegration. OBJECTIVE:The aim of the present animal experiment was to study bone healing at implant sites with hard tissue defect...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2004.00502.x

    authors： Botticelli D,Berglundh T,Lindhe J

    更新日期：2004-04-01 00:00:00

  • Gingival phenotypes in young male adults.

    abstract：:In a previous study on 42 young adult, periodontally healthy subjects without any attrition, abrasion or crown restoration, gingival thickness (GTH) was determined at facial aspects of premolars, canines and incisors by a novel ultrasonic device. GTH strongly depended on periodontal probing depth, width of gingiva (WG...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1997.tb01186.x

    authors： Müller HP,Eger T

    更新日期：1997-01-01 00:00:00

  • Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects.

    abstract：:The present clinical trial was designed to evaluate the effects of a bioactive glass, Perioglas, in the treatment of periodontal intrabony defects. 20 patients, 23-55 years of age (44 sites), with intrabony defects completed the 1-year study. Teeth with furcation involvement were excluded. After completion of initial ...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1600-051x.1997.tb00205.x

    authors： Zamet JS,Darbar UR,Griffiths GS,Bulman JS,Brägger U,Bürgin W,Newman HN

    更新日期：1997-06-01 00:00:00

  • Oscillating/rotating electric toothbrushes compared: plaque removal and gingival abrasion.

    abstract：OBJECTIVES:This study was designed to test the efficacy in plaque removal and the potential for gingival abrasion of 3 electric toothbrushes. The established Braun Oral-B 'Ultra' plaque remover (D9), the Philips/Jordan HP 735, and the newly designed Braun Oral-B 3D Plaque Remover (3D). MATERIAL AND METHODS:This study ...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1034/j.1600-051x.2001.028006536.x

    authors： van der Weijden GA,Timmerman MF,Piscaer M,Ijzerman Y,van der Velden U

    更新日期：2001-06-01 00:00:00

  • Effects of academic stress on oral hygiene--a potential link between stress and plaque-associated disease?

    abstract：BACKGROUND:While there seems to be a common belief that psychosocial stress affects oral hygiene behavior, this assumption has rarely been proved. The present study thus aims to analyse stress effects on oral hygiene. MATERIAL AND METHODS:16 matched pairs of medical students each consisting of 1 student participating ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.2001.028005459.x

    authors： Deinzer R,Hilpert D,Bach K,Schawacht M,Herforth A

    更新日期：2001-05-01 00:00:00

  • Modulation of clinical expression of plaque-induced gingivitis. I. Background review and rationale.

    abstract：OBJECTIVES:The purpose of this article is to provide the necessary background and rationale for the accompanying studies, which are ultimately aimed at identifying genetic and environmental factors determining gingivitis susceptibility. MATERIALS AND METHODS:The literature on factors reported to modify the clinical ex...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-051x.2004.00477.x

    authors： Tatakis DN,Trombelli L

    更新日期：2004-04-01 00:00:00

  • Subgingival temperature (I). Relation to baseline clinical parameters.

    abstract：:44 subjects ranging in age from 14-71 years were measured at 6 sites per tooth for gingival redness, plaque accumulation, suppuration, bleeding on probing, pocket depth and attachment level. Subgingival temperatures were measured at the same 6 sites per tooth using a periodontal temperature probe (Periotemp, Abiodent,...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1992.tb00670.x

    authors： Haffajee AD,Socransky SS,Goodson JM

    更新日期：1992-07-01 00:00:00

  • Ridge regeneration of damaged extraction sockets using rhBMP-2: an experimental study in canine.

    abstract：OBJECTIVES:This study evaluated the dimensional ridge alteration in a buccal-bone-deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP-2) or a collagen membrane covering. MATERIAL AND METHODS:In five beagle dogs, entire bucca...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12414

    authors： Lee JS,Jung JS,Im GI,Kim BS,Cho KS,Kim CS

    更新日期：2015-07-01 00:00:00

  • Eruption cyst formation associated with cyclosporin A.

    abstract：BACKGROUND:Cyclosporin A (CyA) is a potent immunomodulatory agent with a wide range of applications. Despite its therapeutic value, multiple adverse effects of CyA have been identified. This case report describes eruption cyst formation as a possible adverse effect of CyA administration during tooth eruption in a boy t...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.2003.02028.x

    authors： Kuczek A,Beikler T,Herbst H,Flemmig TF

    更新日期：2003-05-01 00:00:00

  • Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.

    abstract：AIM:The current investigation evaluated changes in levels and proportions of 40 bacterial species in subgingival plaque samples during, immediately after and up to 1 year after metronidazole or amoxicillin therapy combined with SRP. METHOD:After baseline clinical and microbiological monitoring, 17 adult periodontitis ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.2001.028007597.x

    authors： Feres M,Haffajee AD,Allard K,Som S,Socransky SS

    更新日期：2001-07-01 00:00:00

  • Absence of a specific subgingival microflora in adults with Down's syndrome.

    abstract：BACKGROUND:Periodontal disease in Down's syndrome (DS) is generally characterized by a high degree of bone loss. Bone loss of 5 mm or more is observed in 70% of these subjects. Among DS subjects, considerable differences in disease progression occur. So far, no studies have been conducted in which specific properties o...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.2001.281103.x

    authors： Reuland-Bosma W,van der Reijden WA,van Winkelhoff AJ

    更新日期：2001-11-01 00:00:00

  • Coronally advanced flap versus the pouch technique combined with a connective tissue graft to treat Miller's class I gingival recession: a randomized controlled trial.

    abstract：AIM:The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller's class I recession: a coronally advanced flap(control group) versus the pouch technique (test group), both of which were associated with connective tissue graft. METHODS:Forty consecutive patients were ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/jcpe.12207

    authors： Salhi L,Lecloux G,Seidel L,Rompen E,Lambert F

    更新日期：2014-04-01 00:00:00

  • Host response to microbial challenge following resective/non-resective periodontal therapy.

    abstract：BACKGROUND:The host response to microbial challenge depends on the recruitment of homing leucocytes and may be related to the experience to infectious insults over years. PURPOSE:The aim of this study was to investigate the soft tissue reactions to de novo plaque formation at sites treated with either open flap debrid...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1600-051X.2005.00746.x

    authors： Zitzmann NU,Lindhe J,Berglundh T

    更新日期：2005-11-01 00:00:00

  • Peripheral ameloblastoma--a clinical dilemma in gingival lesions.

    abstract：:A case of peripheral ameloblastoma on the gingiva of a 50-year-old male is presented. The clinical and histological picture of the lesion is described. The etiology and the dilemma in the differential diagnosis of this peripheral odontogenic tumor is discussed. ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1987.tb00985.x

    authors： Horowitz I,Hirshberg A,Dayan D

    更新日期：1987-07-01 00:00:00

  • Regeneration of alveolar bone following surgical and non-surgical periodontal treatment.

    abstract：:The purpose of this investigation was to examine the regeneration of alveolar bone following surgical and non-surgical periodontal treatment. A total of 16 patients who had advanced periodontitis and demonstrated angular bony defects on radiographs participated in the study. After the initial examination, they receive...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1985.tb00940.x

    authors： Isidor F,Attström R,Karring T

    更新日期：1985-09-01 00:00:00

  • Effect of 3 dentifrices containing triclosan and various additives. An experimental gingivitis study.

    abstract：BACKGROUND:The antiplaque and antigingivitis effect of 3 dentifrices was evaluated using the 21-day partial-mouth experimental model of gingivitis. METHOD:25 volunteers took part in this cross-over, double-blind study, carried out in 4 phases of 21 days each. For each phase of the study, a toothshield of the IV quadra...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1034/j.1600-051x.2000.027007494.x

    authors： Nogueira-Filho GR,Toledo S,Cury JA

    更新日期：2000-07-01 00:00:00

  • The prospective study of autotransplanted severely impacted developing premolars: periodontal status and the long-term outcome.

    abstract：AIMS:To determine the periodontal status and long-term outcomes of the surgical treatment of severely impacted developing premolars. MATERIALS AND METHODS:Nine impacted and adversely angulated second premolars (four maxillary and five mandibular) were autotransplanted from their initial position to the ideal position ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12243

    authors： Plakwicz P,Czochrowska EM

    更新日期：2014-05-01 00:00:00

  • Epigenetic and inflammatory events in experimental periodontitis following systemic microbial challenge.

    abstract：AIM:The purpose of this study was to determine inflammatory and epigenetic features following induction of oral and gut dysbiosis in experimental periodontitis in order to examine the interplay between oral and systemic infection. MATERIALS AND METHODS:Periodontitis was induced in 6- to 8-week-old C57BL/6 mice by (a) ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.13151

    authors： Palioto DB,Finoti LS,Kinane DF,Benakanakere M

    更新日期：2019-08-01 00:00:00