Stimulation of the AT2 receptor reduced atherogenesis in ApoE(-/-)/AT1A(-/-) double knock out mice.

abstract：:The present study was designed in order to investigate more precisely the role of calcium homeostasis maintenance in protein kinase C (PKC) mediated preconditioning. We used a 15 min pre-incubation period, with 1 mumol/l exogenous norepinephrine (NE) to pharmacologically precondition isolated, superfused rat trabecula...

journal_title：Journal of molecular and cellular cardiology

authors： Musters RJ,van der Meulen ET,van der Laarse WJ,van Hardeveld C

更新日期：1997-05-01 00:00:00

abstract：:Cardiac myosin binding protein-C (cMyBP-C) has 11 immunoglobulin or fibronectin-like domains, C0 through C10, which bind sarcomeric proteins, including titin, myosin and actin. Using bacterial expressed mouse N-terminal fragments (C0 through C3) in an in vitro motility assay of myosin-generated actin movement and the ...

journal_title：Journal of molecular and cellular cardiology

authors： Weith A,Sadayappan S,Gulick J,Previs MJ,Vanburen P,Robbins J,Warshaw DM

更新日期：2012-01-01 00:00:00

abstract：:Angiotensin II (Ang II) induces cardiac hypertrophy and fibrosis in part by stimulating endothelin (ET-1) transcription. The involvement of the epigenetic machinery in this process is largely undefined. In the present study, we examined the epigenetic maneuvering underlying cardiac hypertrophy and fibrosis following E...

journal_title：Journal of molecular and cellular cardiology

authors： Weng X,Yu L,Liang P,Li L,Dai X,Zhou B,Wu X,Xu H,Fang M,Chen Q,Xu Y

更新日期：2015-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition is implicated in the remodelling of tissues during development and in the adult life. In the heart, it gives origin to progenitors of fibroblasts, coronary endothelium, smooth muscle cells, and cardiomyocytes. Moreover, epicardially-derived cells determine myocardial wall thickness an...

journal_title：Journal of molecular and cellular cardiology

authors： Di Meglio F,Castaldo C,Nurzynska D,Romano V,Miraglia R,Bancone C,Langella G,Vosa C,Montagnani S

更新日期：2010-11-01 00:00:00

abstract：:The p66shc adaptor protein mediates age-associated oxidative stress. We examined the role of p66shc in endothelial nitric oxide synthase (eNOS) signaling. Overexpression of p66shc inhibited eNOS-dependent NO production. RNAi-mediated down-regulation of endogenous p66shc led to activation of the proto-oncogene ras, and...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamori T,White AR,Mattagajasingh I,Khanday FA,Haile A,Qi B,Jeon BH,Bugayenko A,Kasuno K,Berkowitz DE,Irani K

更新日期：2005-12-01 00:00:00

abstract：:Antibodies directed against the second extracellular loop of G protein-coupled receptors have been shown to exert "agonist-like" activities. In order to test the hypothesis that this is a general phenomenon, antibodies were raised in rabbits against a synthetic peptide corresponding to the second extracellular loop of...

journal_title：Journal of molecular and cellular cardiology

authors： Sallé L,Eftekhari P,Aupart M,Cosnay P,Hoebeke J,Argibay JA

更新日期：2001-03-01 00:00:00

abstract：:Biglycan, a small dermatan sulphate proteoglycan, has been postulated to interact with other components of the extracellular matrix (ECM), specifically collagens. We hypothesized that biglycan messenger ribonucleic acid (mRNA) is increased in the myocardial infarct zone. Biglycan mRNA expression after acute myocardial...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamoto K,Kusachi S,Ninomiya Y,Murakami M,Doi M,Takeda K,Shinji T,Higashi T,Koide N,Tsuji T

更新日期：1998-09-01 00:00:00

abstract：:In view of considerable gaps in our knowledge of myocardial peroxisomes. the aim of the present study is, on the basis of extensive electron-microscopic investigations, to provide reliable results on the inducibility of a proliferation (increase in the number) of these organelles in rodents' heart by several agents an...

journal_title：Journal of molecular and cellular cardiology

authors： Zipper J

更新日期：1997-01-01 00:00:00

abstract：:Cardiac fibroblasts represent one of the most frequent cell type in the heart of rodents and humans and alterations of their phenotype have a great impact on cardiac function. Due to aging, ischemic injuries, valvular dysfunctions, hypertension and aortic stenosis, multiple signals trigger the accumulation of extracel...

journal_title：Journal of molecular and cellular cardiology

authors： Piccoli MT,Bär C,Thum T

更新日期：2016-03-01 00:00:00

abstract：:Cardiomyocytes represent one of the most useful models to conduct cardiac research. A single adult heart yields millions of cardiomyocytes, but these cells do not survive for long after isolation. We aimed to determine whether inhibition of myosin II ATPase that is essential for muscle contraction may preserve fully d...

journal_title：Journal of molecular and cellular cardiology

authors： Abi-Gerges N,Pointon A,Pullen GF,Morton MJ,Oldman KL,Armstrong D,Valentin JP,Pollard CE

更新日期：2013-11-01 00:00:00

abstract：:The incidence of ventricular arrhythmias is higher in failing hearts than in control hearts, especially during acute ischemia. Electrophysiological and extracellular ionic changes during acute ischemia in normal and failing rabbit myocardium were assessed. Heart failure was induced in rabbits by combined volume and pr...

journal_title：Journal of molecular and cellular cardiology

authors： Vermeulen JT,Tan HL,Rademaker H,Schumacher CA,Loh P,Opthof T,Coronel R,Janse MJ

更新日期：1996-01-01 00:00:00

abstract：:Although endothelial progenitor cells (EPCs) play a pivotal role in the endothelial repair following arterial injury and shear stress has a beneficial effect on EPCs, however, the molecular mechanism underlying the influence of EPCs on the endothelial integrity and the regulation of shear stress on the EPC signaling r...

journal_title：Journal of molecular and cellular cardiology

authors： Yang Z,Xia WH,Zhang YY,Xu SY,Liu X,Zhang XY,Yu BB,Qiu YX,Tao J

更新日期：2012-05-01 00:00:00

abstract：:With electrophysiological methods, mechanisms of the restorative action of coenzyme Q10 (CoQ10) in 2,4-dinitrophenol-depressed electrical and mechanical activities of isolated guinea-pig hearts were studied. Isoproterenol (3 X 10(-8) M)-induced action potential and contraction of the heart in 27 mM KCl Tyrode solution...

journal_title：Journal of molecular and cellular cardiology

authors： Furukawa K,Yamasaki Y,Kizu A,Furukawa K,Katsume H,Ijichi H,Kitamura K

更新日期：1983-09-01 00:00:00

abstract：:Cardiac progenitor cells (CPCs) are a crucial source of cells in cardiac development and regeneration. However, reported CPCs are heterogeneous, and no gene has been identified to transiently mark undifferentiated CPCs throughout heart development. Here we show that Spalt-like gene 1 (Sall1), a zing-finger transcripti...

journal_title：Journal of molecular and cellular cardiology

authors： Morita Y,Andersen P,Hotta A,Tsukahara Y,Sasagawa N,Hayashida N,Koga C,Nishikawa M,Saga Y,Evans SM,Koshiba-Takeuchi K,Nishinakamura R,Yoshida Y,Kwon C,Takeuchi JK

更新日期：2016-03-01 00:00:00

abstract：:We measured myosin crossbridge detachment rate and the rates of MgADP release and MgATP binding in mouse and rat myocardial strips bearing one of the two cardiac myosin heavy chain (MyHC) isoforms. Mice and rats were fed an iodine-deficient, propylthiouracil diet resulting in ~100% expression of β-MyHC in the ventricl...

journal_title：Journal of molecular and cellular cardiology

authors： Wang Y,Tanner BC,Lombardo AT,Tremble SM,Maughan DW,Vanburen P,Lewinter MM,Robbins J,Palmer BM

更新日期：2013-01-01 00:00:00

abstract：:Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme...

journal_title：Journal of molecular and cellular cardiology

authors： Lau D,Szöcs K,Klinke A,Rudolph T,Rudolph V,Streichert T,Blankenberg S,Baldus S

更新日期：2014-04-01 00:00:00

abstract：:The present study was undertaken to assess whether [32P]uptake and autoradiography could be used as an indicator of regional myocardial oxygen consumption. Rat hearts were perfused in the Langendorff mode with medium containing [32P]orthophosphate (32Pi) and the incorporation of label into ATP, perchloric acid-insolub...

journal_title：Journal of molecular and cellular cardiology

authors： Richards SM,Rattigan S,Colquhoun EQ,Clark MG

更新日期：1993-03-01 00:00:00

abstract：:We evaluated whether phospholemman (PLM) regulates L-type Ca(2+) current (ICa) in mouse ventricular myocytes. Expression of α1-subunit of L-type Ca(2+) channels between wild-type (WT) and PLM knockout (KO) hearts was similar. Compared to WT myocytes, peak ICa (at -10 mV) from KO myocytes was ~41% larger, the inactivat...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang XQ,Wang J,Song J,Rabinowitz J,Chen X,Houser SR,Peterson BZ,Tucker AL,Feldman AM,Cheung JY

更新日期：2015-07-01 00:00:00

abstract：:Defective sarcoplasmic reticulum (SR) Ca2+ handling is evident in cardiomyopathy and may be mediated by selective dysregulation of SR Ca2+ handling proteins. To assess whether regulation of SR Ca2+ release may vary regionally within the normal and diseased heart, left ventricular transmural expression and activity of ...

journal_title：Journal of molecular and cellular cardiology

authors： Currie S,Quinn FR,Sayeed RA,Duncan AM,Kettlewell S,Smith GL

更新日期：2005-08-01 00:00:00

abstract：:We evaluated the time course of activation of endocardial endothelial cells and cardiomyocytes in adult rats with pressure overload induced by the abdominal aortic constriction. The silver staining technique for nucleolar organizer region was used to mark an increased transcriptional activity of the cells. An increase...

journal_title：Journal of molecular and cellular cardiology

authors： Horký M,Horský P,Kolár F

更新日期：1997-09-01 00:00:00

abstract：:Ca(2+) flux through l-type CaV1.2 channels shapes the waveform of the ventricular action potential (AP) and is essential for excitation-contraction (EC) coupling. Timothy syndrome (TS) is a disease caused by a gain-of-function mutation in the CaV1.2 channel (CaV1.2-TS) that decreases inactivation of the channel, which...

journal_title：Journal of molecular and cellular cardiology

authors： Drum BM,Dixon RE,Yuan C,Cheng EP,Santana LF

更新日期：2014-01-01 00:00:00

abstract：:The activation of vascular smooth muscle cells (SMCs) in neointimal hyperplasia involves signaling through receptor tyrosine kinases as well as G protein-coupled receptors. Overexpression of G protein-coupled receptor kinase-2 (GRK2) in SMCs can attenuate mitogenic signaling and proliferation in response to not only s...

journal_title：Journal of molecular and cellular cardiology

authors： Peppel K,Zhang L,Huynh TT,Huang X,Jacobson A,Brian L,Exum ST,Hagen PO,Freedman NJ

更新日期：2002-10-01 00:00:00

abstract：:We previously reported the induction of calcium-dependent calcium release and depolarization of membrane potential of cardiac mitochondria from rats treated chronically (13 weeks) with doxorubicin. The fact that this was inhibited by cyclosporine A and ruthenium red suggests induction of the mitochondrial permeability...

journal_title：Journal of molecular and cellular cardiology

authors： Solem LE,Heller LJ,Wallace KB

更新日期：1996-05-01 00:00:00

abstract：:Recently discovered endothelin is a powerful vasoconstrictor of vascular smooth muscle in vitro, which also profoundly affects the mechanical function of the heart. An increased level of plasma endothelin in patients with acute myocardial infarction suggests the enhanced release of endothelin from vascular endothelium...

journal_title：Journal of molecular and cellular cardiology

authors： Prasad MR,Jones RM,Kreutzer DL

更新日期：1991-06-01 00:00:00

abstract：:K. Suzuki, S. Kostin, V. Person, A. Elsässer and J. Schaper. Time Course of the Apoptotic Cascade and Effects of Caspase Inhibitors in Adult Rat Ventricular Cardiomyocytes. Journal of Molecular and Cellular Cardiology (2001) 33, 983-994. Interpretation of the rate of apoptosis in diseased hearts is hampered by the fac...

journal_title：Journal of molecular and cellular cardiology

authors： Suzuki K,Kostin S,Person V,Elsässer A,Schaper J

更新日期：2001-05-01 00:00:00

abstract：:Heat shock protein 70 (HSP70) has been shown to play a fundamental role in the induction of thermotolerance in many biological systems. Elevated synthesis of HSP70 in response to diverse stresses such as heat, anoxia, ischaemia, ethanol and heavy metals has been correlated with protection against subsequent more sever...

journal_title：Journal of molecular and cellular cardiology

authors： Heads RJ,Latchman DS,Yellon DM

更新日期：1994-06-01 00:00:00

abstract：:Hemodynamic and electron spin resonance analyses were used to assess the in vivo and in vitro cardioprotective and antioxidant effects of therapeutically relevant doses of Ginkgo biloba extract (EGb 761) and its terpenoid constituents (ginkgolides A and B, bilobalide) in the rat. Significant anti-ischemic effects, ind...

journal_title：Journal of molecular and cellular cardiology

authors： Pietri S,Maurelli E,Drieu K,Culcasi M

更新日期：1997-02-01 00:00:00

abstract：:The ATP-sensitive K(+) (K(ATP)) channel is composed of four pore-forming Kir6.2 subunits and four sulfonylurea receptors (SUR). Intracellular ATP inhibits K(ATP) channels through Kir6.2. SUR is an ABC protein bearing transmembrane domains and two nucleotide-binding domains (NBD1 and NBD2). SUR increases the open proba...

journal_title：Journal of molecular and cellular cardiology

authors： Yamada M,Kurachi Y

更新日期：2005-07-01 00:00:00

abstract：:The cardiac troponin I gene has been described to be associated with hypertrophic cardiomyopathy. Until now, mutations in this gene have been found only in the Japanese population. We now present the first non-Japanese family, from northern Sweden, with a mutation in the cardiac troponin I gene. Clinical diagnose was ...

journal_title：Journal of molecular and cellular cardiology

authors： Mörner S,Richard P,Kazzam E,Hainque B,Schwartz K,Waldenström A

更新日期：2000-03-01 00:00:00

abstract：:Cardiocyte loss during myocardial hypertrophy leads to progressive dysfunction in human hearts with chronic hemodynamic overload. The mechanism for such cell elimination is unknown. We examined lysosomal participation in cardiocytic degradation present in human cardiac biopsies, utilizing electron microscopic cytochem...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamoto S,Sawada K,Shimomura H,Kawamura K,James TN

更新日期：2000-01-01 00:00:00