Abstract：
:The objective of this study was to develop a nanoscratch technique that can be used to measure the in situ toughness of bone at micro/nanostructural levels. Among the currently possible techniques, the surface scratch test may be conducted on very small regions, thus exhibiting a potential in determining the in situ failure behavior of materials. To adapt such a technique for assessing bone toughness at the micro/nanostructural levels and for limited stocks in small animal bone models (e.g. zebra finish and mice), a simple but reasonably accurate mechanistic model for the nanoscratch test was developed in this study. This model was based on the assumption that the removal energy of the tissue required during the nanoscratch test is the manifestation of the in situ toughness and the shear flow stress during the removal process is a measure of the in situ strength of bone. In addition, the experimental methodologies were developed to determine the elastic recovery force and frictional coefficients between the scratch tip and bone specimens that are required by the model. Finally, the efficacy of the nanoscratch technique was verified by testing bone samples from control (wild type), mild, and severe osteogenesis imperfecta (OI) mice, which have a distinct degree of brittleness. The experimental results indicated that the nanoscratch test could sensitively detect the in situ brittleness and strength of bone from the animal models.
journal_name
J Mech Behav Biomed Materauthors
Islam A,Neil Dong X,Wang Xdoi
10.1016/j.jmbbm.2011.08.019subject
Has Abstractpub_date
2012-01-01 00:00:00pages
156-64issue
1eissn
1751-6161issn
1878-0180pii
S1751-6161(11)00224-4journal_volume
5pub_type
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