当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > Predominant role of obesity/insulin resistance in oxidative stress development.

Predominant role of obesity/insulin resistance in oxidative stress development.

Abstract：

BACKGROUND:  Hyperlipidaemia, hyperglycaemia and hyperinsulinaemia, hallmarks of the postprandial state, have been also associated with increased oxidative stress and lipoprotein oxidation contributing to vascular injury and atherosclerosis. However, the specific links among metabolic disorders, postprandial state, insulin resistance and oxidative stress are still to be clarified. This study aimed at investigating the individual role played by obesity, insulin resistance and type 2 diabetes in the occurrence of fasting and postprandial oxidative stress. DESIGN:Biomarkers of oxidative stress [F2-isoprostanes and circulating oxidized low-density lipoproteins (LDL)], LDL oxidability (conjugated diene kinetic, thiobarbituric acid reactive substances (TBARs) formation and electronegativity increase) and antioxidant vitamins (β-carotene, α-tocopherol and retinol) were evaluated at fasting and 6 h after a standard fat-rich meal in 10 obese diabetic (ObD), 11 obese and 11 normal-weight control men. Insulin sensitivity was evaluated by euglycaemic hyperinsulinaemic clamp. RESULTS:ObD and obese subjects, characterized by a similar level of adiposity and insulin resistance, showed higher urinary F2-isoprostanes and circulating oxidized LDL, an increased susceptibility to oxidation of plasma LDL (lower lag phase, higher TBARs formation, and higher relative electrophoretic mobility), and lower plasma content of β-carotene and retinol than control subjects, both at fasting and after the test meal. CONCLUSIONS:Obesity and insulin resistance, more than type 2 diabetes, play the most relevant role in oxidative stress development. The correction of obesity and insulin resistance might be a useful strategy in counteracting systemic oxidative stress.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

D'Archivio M,Annuzzi G,Varì R,Filesi C,Giacco R,Scazzocchio B,Santangelo C,Giovannini C,Rivellese AA,Masella R

doi

10.1111/j.1365-2362.2011.02558.x

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

70-8

issue

1

eissn

0014-2972

issn

1365-2362

journal_volume

42

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION文献大全
  • Suppression of the nocturnal free fatty acid levels by bedtime cornstarch in NIDDM subjects.

    abstract：:The aim of the present study was to examine the effects of a large dose of slow-release carbohydrates (CHOs) at bedtime on the nocturnal glucose, insulin and free fatty acid (FFA) levels, and to assess the putative effects on morning fasting and post-prandial glucose levels in patients with moderately controlled non-i...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2362.1997.880639.x

    authors： Axelsen M,Lönnroth P,Arvidsson Lenner R,Smith U

    更新日期：1997-02-01 00:00:00

  • Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia.

    abstract：BACKGROUND:Excess of cardiovascular risk among patients with chronic inflammatory diseases has been attributed to increased arterial stiffness. Hypercholesterolaemia has been demonstrated to promote a low-grade inflammatory status. The objective of the present study was to define, in hypercholesterolaemia, the influenc...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2004.01345.x

    authors： Pirro M,Schillaci G,Savarese G,Gemelli F,Vaudo G,Siepi D,Bagaglia F,Mannarino E

    更新日期：2004-05-01 00:00:00

  • Metabolic abnormalities of apolipoprotein B-containing lipoproteins in non-insulin-dependent diabetes: a stable isotope kinetic study.

    abstract：BACKGROUND:Kinetic abnormalities of apolipoprotein B (apoB)-containing lipoproteins in noninsulin-dependent diabetes mellitus (NIDDM) remain poorly understood. To get further insight into these abnormalities we performed a stable isotope kinetic experiment comparing the metabolism of apoB-containing lipoproteins in mod...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：

    authors： Duvillard L,Pont F,Florentin E,Galland-Jos C,Gambert P,Vergès B

    更新日期：2000-08-01 00:00:00

  • C5a anaphylatoxin and its role in critical illness-induced organ dysfunction.

    abstract：:Critical illness is an aetiologically and clinically heterogeneous syndrome that is characterised by organ failure and immune dysfunction. Mortality in critically ill patients is driven by inflammation-associated organ damage and a profound vulnerability to nosocomial infection. Both factors are influenced by the acti...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/eci.13028

    authors： Wood AJT,Vassallo A,Summers C,Chilvers ER,Conway-Morris A

    更新日期：2018-12-01 00:00:00

  • Thiopurine metabolism monitoring: implications in inflammatory bowel diseases.

    abstract：BACKGROUND:Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. MATERIALS AND METHODS:Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. RESULTS:TP metabolism is...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2010.02346.x

    authors： Dewit O,Starkel P,Roblin X

    更新日期：2010-11-01 00:00:00

  • Density and agonist-promoted high and low affinity states of the beta-adrenoceptor on human B- and T-cells.

    abstract：:beta-Adrenoceptor binding on peripheral blood mononuclear cells (PBMC) of healthy adult volunteers was investigated using the radioligand 125iodo-cyanopindolol (ICYP). Saturation binding studies were performed with nine different concentrations of ICYP. Receptor density and affinity were calculated by Scatchard plots....

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1988.tb02416.x

    authors： Griese M,Körholz U,Körholz D,Seeger K,Wahn V,Reinhardt D

    更新日期：1988-04-01 00:00:00

  • 'Omics'-driven discoveries in prevention and treatment of type 2 diabetes.

    abstract：:Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2362.2012.02678.x

    authors： Gjesing AP,Pedersen O

    更新日期：2012-06-01 00:00:00

  • Liver enzymes are not directly involved in atrial fibrillation: a prospective cohort study.

    abstract：BACKGROUND:Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation i...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,多中心研究

    doi：10.1111/eci.12779

    authors： Schutte R,Whincup PH,Papacosta O,Lennon LT,Macfarlane PW,Wannamethee G

    更新日期：2017-08-01 00:00:00

  • The ontogeny and site of intestinal lipid and lipoprotein synthesis.

    abstract：:The developmental aspects of characteristic intestinal lipoprotein synthesis, chlomicrons (CM), very low density lipoproteins (VLDL) and high density lipoproteins (HDL), are unknown. Our objective was to determine the ontogeny of intestinal lipid and lipoprotein synthesis in both the jejunum and the ileum. Explants of...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1992.tb01945.x

    authors： Mehran M,Thibault L,Russo P,Garofalo C,Levy E

    更新日期：1992-02-01 00:00:00

  • Effect of obesity and insulin sensitivity on adiponectin isoform distribution.

    abstract：BACKGROUND:Adiponectin is an insulin-sensitizing, antiatherogenic and anti-inflammatory adipocytokine that circulates in three isoforms: a trimer [low-molecular weight (LMW)], a hexamer (trimer-dimer) of medium molecular weight (MMW) and a multimeric high molecular weight (HMW) isoform. Evidence is accumulating that HM...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2008.02028.x

    authors： Kaser S,Tatarczyk T,Stadlmayr A,Ciardi C,Ress C,Tschoner A,Sandhofer A,Paulweber B,Ebenbichler CF,Patsch JR

    更新日期：2008-11-01 00:00:00

  • Aortic distensibility is reduced in subjects with type 2 diabetes and cardiac autonomic neuropathy.

    abstract：BACKGROUND:Reduced aortic distensibility predicts cardiovascular mortality in patients with type 2 diabetes and impaired glucose tolerance. Cardiac autonomic neuropathy is common in subjects with diabetes. However, the relationship between the elastic properties of the aorta and autonomic neuropathy has not been studie...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2003.01279.x

    authors： Tentolouris N,Liatis S,Moyssakis I,Tsapogas P,Psallas M,Diakoumopoulou E,Voteas V,Katsilambros N

    更新日期：2003-12-01 00:00:00

  • Accuracy of prehospital point-of-care lactate in early in-hospital mortality.

    abstract：BACKGROUND:Emergency medical services (EMS) routinely face complex scenarios where decisions should be taken with limited clinical information. The development of fast, reliable and easy to perform warning biomarkers could help in such decision-making processes. The present study aims at characterizing the validity of ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13341

    authors： Martín-Rodríguez F,López-Izquierdo R,Medina-Lozano E,Ortega Rabbione G,Del Pozo Vegas C,Carbajosa Rodríguez V,Castro Villamor MÁ,Sánchez-Soberon I,Sanz-García A

    更新日期：2020-12-01 00:00:00

  • Platelet noradrenaline release in patients with familial hypercholesterolaemia.

    abstract：:We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thro...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1989.tb00225.x

    authors： Smith CC,Wilson AP,Prichard BN,Betteridge DJ

    更新日期：1989-06-01 00:00:00

  • Intravenous clusterin administration reduces myocardial infarct size in rats.

    abstract：BACKGROUND:Clusterin (Apolipoprotein J), a plasma protein with cytoprotective and complement-inhibiting activities, localizes in the infarcted heart during myocardial infarction (MI). Recently, we have shown a protective effect of exogenous clusterin in vitro on ischaemically challenged cardiomyocytes independent of co...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02345.x

    authors： Van Dijk A,Vermond RA,Krijnen PA,Juffermans LJ,Hahn NE,Makker SP,Aarden LA,Hack E,Spreeuwenberg M,van Rossum BC,Meischl C,Paulus WJ,Van Milligen FJ,Niessen HW

    更新日期：2010-10-01 00:00:00

  • Chronic erythropoietin treatment affects different molecular pathways of diabetic cardiomyopathy in mouse.

    abstract：BACKGROUND:Recent studies in mice experimental models with acute ischaemic injury revealed that erythropoietin (EPO) has numerous tissue-protective effects in the heart, brain and kidneys. We therefore explored the tissue-protective properties of chronic EPO treatment in an experimental model of the db/db mouse with di...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2009.02165.x

    authors： Shushakova N,Park JK,Menne J,Fliser D

    更新日期：2009-09-01 00:00:00

  • Hyperaluminaemia in critically ill patients: role of antacid therapy and impaired renal function.

    abstract：:A significant rise in serum concentrations of aluminum was demonstrated in 23 patients prophylactically treated with the antacid magaldrate, whereas no increase in serum aluminium was observed in another 26 critically ill patients, in whom the use of antacids was avoided. In parallel, urinary excretion rates of alumin...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1991.tb01365.x

    authors： Ittel TH,Gladziwa U,Mück W,Sieberth HG

    更新日期：1991-02-01 00:00:00

  • Immunologic and viral markers in the circulation of anti-HIV negative heroin addicts.

    abstract：:To assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleuk...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1993.tb00765.x

    authors： Dalekos GN,Manoussakis MN,Zervou E,Tsianos EV,Moutsopoulos HM

    更新日期：1993-04-01 00:00:00

  • Very long chain n-3 and n-6 polyunsaturated fatty acids inhibit proliferation of human T-lymphocytes in vitro.

    abstract：:The effect of marine n-3 polyunsaturated fatty acids on proliferation of human T-cells in vitro was compared to other polyunsaturated, monounsaturated and saturated fatty acids. Monoenes and saturated fatty acids had little effect on T-cell proliferation. Eicosapentaenoic acid and docosahexaenoic acid exerted a strong...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1993.tb00750.x

    authors： Søyland E,Nenseter MS,Braathen L,Drevon CA

    更新日期：1993-02-01 00:00:00

  • The relation between body iron stores and adipose tissue function in patients with manifest vascular disease.

    abstract：BACKGROUND:We investigated whether plasma ferritin levels through the pro-inflammatory effects of free iron are associated with adipose tissue dysfunction in a relevant population of patients with manifest vascular disease who would potentially benefit the most from further aetiological insights. MATERIALS AND METHODS...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12165

    authors： Westerink J,Olijhoek JK,Koppen A,Faber DR,Kalkhoven E,Monajemi H,van Asbeck BS,van der Graaf Y,Visseren FL

    更新日期：2013-12-01 00:00:00

  • A comparative study of two methods of measurement of fractional calcium absorption: results in normal individuals and patients with various disturbances of calcium metabolism.

    abstract：:Two methods of measurement of fractional calcium absorption have been compared in the same individuals. There is a significant correlation between fractional 47Ca absorption as measured with a blood counting method and with an external counting method after intravenous and oral administration of 47Ca (P less than 0.00...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1978.tb00826.x

    authors： Juttmann JR,Ruis AM,Hagenouw-Taal JC,Lockefeer JH,Birkenhäger JC

    更新日期：1978-06-01 00:00:00

  • Endothelial dysfunction in Buerger's disease and its relation to markers of inflammation.

    abstract：BACKGROUND:Buerger's disease (BD) is a segmental occlusive vascular disease. The aim of this study was to detect functional changes in brachial artery and asymptomatic morphological changes in extra-cranial carotid arteries not affected by the disease process and to assess markers of inflammation and endothelial damage...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2006.01646.x

    authors： Joras M,Poredos P,Fras Z

    更新日期：2006-06-01 00:00:00

  • Primary hyperparathyroidism: evaluated by 47calcium kinetics, calcium balance and serum bone-Gla-protein.

    abstract：:Combined 47Calcium kinetic and calcium balance studies with correction for dermal calcium loss were performed in thirteen patients with primary hyperparathyroidism (PHP), in whom serum bone-Gla-protein (S-BGP) was measured, and in ten matched controls. Dietary calcium was normal in PHP but both net (7.9 +/- 1.4 mmol C...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1986.tb01342.x

    authors： Charles P,Mosekilde L,Jensen FT

    更新日期：1986-08-01 00:00:00

  • Glutathione, glutathione utilizing enzymes and thioltransferase in platelets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications.

    abstract：:Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evalu...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1995.tb01983.x

    authors： Di Simplicio P,de Giorgio LA,Cardaioli E,Lecis R,Miceli M,Rossi R,Anichini R,Mian M,Seghieri G,Franconi F

    更新日期：1995-09-01 00:00:00

  • Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans.

    abstract：BACKGROUND:The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypo...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2006.01615.x

    authors： Bischof MG,Brehm A,Bernroider E,Krssák M,Mlynárik V,Krebs M,Roden M

    更新日期：2006-03-01 00:00:00

  • Immunochemical and biomolecular studies of circulating immune complexes isolated from patients with acute and chronic hepatitis C virus infection.

    abstract：:Circulating immune complexes (ICs) were isolated by affinity chromatography and sucrose density gradient fractionation during acute and chronic hepatitis C virus (HCV) infection. Immunochemical and biomolecular studies showed that they basically consist of the virus component, IgG with specific anti-HCV activity and I...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1996.162317.x

    authors： Sansonno D,Iacobelli AR,Cornacchiulo V,Lauletta G,Distasi MA,Gatti P,Dammacco F

    更新日期：1996-06-01 00:00:00

  • Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion.

    abstract：:The effect of the potent specific cholecystokinin (CCK) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of CCK, gastrin, pancreatic polypeptide (PP), neurotensin, glucose-dependent insulinotropic polypeptide (GIP), insulin and C peptide was investigated in a placebo-controlled study in 10 heal...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2362.1991.tb01402.x

    authors： Schmidt WE,Creutzfeldt W,Höcker M,Nustede R,Choudhury AR,Schleser A,Rovati LC,Fölsch UR

    更新日期：1991-10-01 00:00:00

  • Short-term overt hypothyroidism induces discrete diastolic dysfunction in patients treated for differentiated thyroid carcinoma.

    abstract：BACKGROUND:Thyroid hormone has important effects on the cardiovascular system. The consequences of episodes of acute hypothyroidism on cardiac function have been investigated in only a few studies, and their results are inconclusive. Our objective was to investigate the effects of acute hypothyroidism on cardiac functi...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2009.02088.x

    authors： Hoftijzer HC,Bax JJ,Heemstra KA,Bleeker GB,Delgado V,van der Klaauw AA,Romijn JA,Smit JW,Corssmit EP

    更新日期：2009-03-01 00:00:00

  • Reverse iontophoresis of urea in health and chronic kidney disease: a potential diagnostic and monitoring tool?

    abstract：BACKGROUND:Patients with chronic kidney disease (CKD) need regular monitoring, usually by blood urea and creatinine measurements, needing venepuncture, frequent attendances and a healthcare professional, with significant inconvenience. Noninvasive monitoring will potentially simplify and improve monitoring. We tested t...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2012.02657.x

    authors： Ebah LM,Read I,Sayce A,Morgan J,Chaloner C,Brenchley P,Mitra S

    更新日期：2012-08-01 00:00:00

  • Antihyperglycemic drugs use and new-onset atrial fibrillation in elderly patients.

    abstract：BACKGROUND:Antihyperglycemic drugs have been linked to new-onset atrial fibrillation (NAF). However, the effect of the different classes of antihyperglycemic drugs on the development of NAF in elderly patients has not been well studied. In this study, we investigated the association between different classes of antihyp...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12754

    authors： Chen HY,Yang FY,Jong GP,Liou YS

    更新日期：2017-05-01 00:00:00

  • In vivo modifications of AcSDKP metabolism and haematopoiesis in mice treated with 5-fluorouracil and Goralatide.

    abstract：BACKGROUND:The tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), a physiological inhibitor of the proliferation of haematopoietic stem cells, is degraded by the angiotensin-I-converting enzyme (ACE). Whereas synthetic AcSDKP (Goralatide) protects normal mice from the haematological toxicity of chemotherapy, it has a lower ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1998.00356.x

    authors： Comte L,Lorgeot V,Bignon J,Volkov L,Dupuis F,Wdzieczak-Bakala J,Praloran V

    更新日期：1998-10-01 00:00:00