Abstract:
:Under the influence of gonadotropins or growth factors, a close cooperation develops between cumulus cells and the oocyte that is implicated in transmitting signals involved in maintaining or releasing the meiotic arrest in the oocyte. While cyclic adenosine 5'-monophosphate (cAMP) is a key molecule in maintaining the meiotic arrest, calcium (Ca(2+)) may play a role in controlling either spontaneous or gonadotropin-induced oocyte maturation, possibly by modulating intracytoplasmic cAMP concentrations via Ca(2+)-sensitive adenylate cyclases. This review focuses on the mechanisms related to the origin of the Ca(2+) wave that travels from the cumulus cells to the oocyte, and discusses the source of variations affecting the dynamics of this wave.
journal_name
Mol Reprod Devjournal_title
Molecular reproduction and developmentauthors
Silvestre F,Boni R,Fissore RA,Tosti Edoi
10.1002/mrd.21332subject
Has Abstractpub_date
2011-10-01 00:00:00pages
744-56issue
10-11eissn
1040-452Xissn
1098-2795journal_volume
78pub_type
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pub_type: 评论,杂志文章
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更新日期:1992-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/(SICI)1098-2795(199612)45:4<431::AID-MRD4>
更新日期:1996-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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