Abstract:
:Tumour tissue from 29 patients with primary brain lymphoma was reviewed to determine if there was an aetiological association between Epstein-Barr virus and polyclonal and monoclonal lymphoproliferations. The morphology and immunophenotype in 24 patients for whom paraffin wax embedded tissue was available were studied. A high grade pleomorphic tumour morphology with plasmacytoid features was seen in 13 tumours. Because of the large number of pleomorphic lymphomas, all tumours were examined for the presence of the Epstein-Barr virus genome using in situ DNA hybridisation. A panel of three biotinylated probes to different sequences in the Epstein-Barr virus genome was used. Positive hybridisation with one or more probes was shown in tumours from 11 patients. The remaining tumours gave no hybridisation signal. There was no correlation between positive hybridisation and morphological subtype or clinical outcome.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Murphy JK,Young LS,Bevan IS,Lewis FA,Dockey D,Ironside JW,O'Brien CJ,Wells Mdoi
10.1136/jcp.43.3.220subject
Has Abstractpub_date
1990-03-01 00:00:00pages
220-3issue
3eissn
0021-9746issn
1472-4146journal_volume
43pub_type
杂志文章abstract::Xanthine oxidase (XO) activity was found to be negligible in sterile human urines (less than 480 units, as presently defined, per litre). Significant XO activity was found in all urines containing more than 10(5) bacteria/ml, except for urines infected with Staphylococcus aureus, in which XO activity ranged from 347 t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.5.444
更新日期:1978-05-01 00:00:00
abstract:AIMS:Hypomethylating agents (HMAs) exhibit clinical efficacy in patients with myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). This study was performed to assess residual disease status by flow cytometry immunophenotyping (FCI) methods in patients with MDS or MDS/MPN treated w...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2016-203715
更新日期:2016-04-15 00:00:00
abstract::A woman with peripheral vascular disease developed cytomegalovirus colitis following repair of abdominal aortic aneurysm. Cytomegalovirus colitis developing in an immunocompetent individual may be caused by a breach in the integrity of the mucosal lining of the colon from various causes and should alert the clinician ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.6.475
更新日期:1998-06-01 00:00:00
abstract:AIM:To investigate the fate of Streptococcus pneumoniae C-polysaccharide antigen in serum in patients with S pneumoniae bacteraemia. METHOD:In vitro dissociation experiments were performed to demonstrate that C-polysaccharide was masked by ligands in normal and acute phase serum. Serum samples from 22 patients with S ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.9.803
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Although Bulgaria has one of the highest rates of cervical cancer incidence and mortality in the EU, data on HPV type distribution are limited. AIM:To determine the prevalence of HPV types 16 and 18 in archival specimens from cervical cancer cases from Bulgaria. METHODS:A total of 145 formalin-fixed, paraf...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2010.080168
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2005.036418
更新日期:2007-04-01 00:00:00
abstract::The air of three hospital wards was examined frequently for staphylococci for a period of nearly four years using slit samplers. ;Broadcasts' of staphylococci into the air were observed with the air count rising well above the mean of 0.2 staphylococcal particle per cubic foot and these broadcasts often appeared to be...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.15.6.552
更新日期:1962-11-01 00:00:00
abstract::Gastrointestinal cell proliferation plays an important role in the maintenance of the integrity of the gastrointestinal system. The study of gastrointestinal proliferation kinetics allows a better understanding of the complexity of the system, and also has important implications for the study of gastrointestinal carci...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.52.5.321
更新日期:1999-05-01 00:00:00
abstract:AIMS:To compare the expression of immunohistochemical variables between benign and malignant components of malignant peripheral nerve sheath tumour (MPNST) arising within neurofibroma. METHODS:Eight cases of MPNST arising within a neurofibroma, associated with neurofibromatosis type 1 (NF1), were studied. The areas of...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.54.8.631
更新日期:2001-08-01 00:00:00
abstract::The principles which should govern the planning of benching and services for new laboratories are enumerated. These include the necessity for long-term planning, flexibility, and economy. The ;Cardiff benching system' where the benches are composed of units that consist of an independent movable table base, a removabl...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.5.480
更新日期:1963-09-01 00:00:00
abstract::Levels of the serum complement components, C3 and C4, in patients with Crohn's disease, ulcerative colitis, and miscellaneous gastrointestinal disorders were compared with those of normal blood donors. Significant increases of both components were found in all three patient groups, the highest being in patients with C...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.32.8.798
更新日期:1979-08-01 00:00:00
abstract::Review of published work and analysis of clinical data and pathology of four biopsy specimens from two patients with laryngeal contact granuloma showed that its peptic origin was derived from a gastro-oesophago-laryngeal reflux. It is proposed that the term "peptic granuloma" should be given to this phenomenon. This t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.8.800
更新日期:1989-08-01 00:00:00
abstract::Twenty-two known strains of the Bacteroides fragilis group of organisms and 67 clinical specimens from a variety of sites were examined by fluorescent antibody test (IFA) using two different antisera fro the rapid detection of B fragilis group of organisms. A previously reported Barts' pooled antisera was compared wit...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.3.304
更新日期:1982-03-01 00:00:00
abstract::Antibodies against alpha smooth muscle actin (ASMA) and S100 protein were applied to paraffin wax embedded sections from 40 salivary gland tumours and seven normal salivary glands. The results indicate that ASMA is useful in the diagnosis of epithelial-myoepithelial carcinoma, but is otherwise only of limited use in d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.10.938
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Breast-conserving surgery currently focuses on improving margin clearance and excision volume, the main pathology report parameters for oncological and cosmetic outcomes. AIM:To quantitatively evaluate discrepancies in surgical and pathological estimates of breast specimen sizes, including the influence of ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jclinpath-2011-200392
更新日期:2012-03-01 00:00:00
abstract::Metabolic balance studies for iron have been carried out on 24 apparently healthy elderly people (11 men and 13 women) aged 69.7 to 85.5 years living in their own homes and eating self selected diets. Several biochemical and haematological indices of iron state were also measured. The mean daily iron intake was 176 mu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.12.1353
更新日期:1984-12-01 00:00:00
abstract:AIMS:To investigate the histopathological changes in the livers of patients undergoing cholecystectomy and to relate these changes to the underlying biliary tract pathology. METHODS:Liver changes in 67 patients undergoing cholecystectomy were investigated. Sixty three had gall stones, one cholesterolosis only, and the...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.5.457
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Serum prostate specific antigen (PSA) increases after radical prostatectomy are thought to indicate recurrent disease, although some suggest they result from benign prostatic epithelial tissue left at surgical margins. AIMS:To investigate whether presence, location, and extent of benign prostatic tissue at ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.024182
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:EpCAM is an adhesion molecule of the basolateral membranes in a variety of epithelial cells. Over-expression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. AIMS:To assess the prognostic value of EpCAM in urothelial ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2007.049460
更新日期:2008-03-01 00:00:00
abstract::A case of abnormal chromatin clumping (ACC) which arose during the course of a myelodysplastic/myeloproliferative syndrome is described in a 61 year old woman who died of haemorrhage 43 months after diagnosis. Mature granulocytes exhibited the same nuclear abnormality described in other patients reported. Unusually, s...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.2.177
更新日期:1993-02-01 00:00:00
abstract::A recently developed procedure, that has been shown to be suitable for detailed immunohistological analysis, has been used to prepare cryostat sections of bone marrow to investigate whether enzyme-histochemical techniques are also feasible on such material. A selected group of enzymes, some of which are inhibited or d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.11.1220
更新日期:1982-11-01 00:00:00
abstract:AIMS:To perform a clinicopathological analysis of a series of primary cutaneous Ewing sarcomas/primitive neuroectodermal tumours (ES/PNET) to highlight the pathological features, discuss the differential diagnosis, emphasise the role of molecular testing (particularly fluorescence in situ hybridisation, FISH) in diagno...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2008.064014
更新日期:2009-10-01 00:00:00
abstract:AIMS:Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. METHODS:Fifteen molecular laboratories from seven different European countries compa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206957
更新日期:2020-07-31 00:00:00
abstract::The relation between the choline containing surfactant phospholipids lecithin and sphingomyelin in amniotic fluid and fetal lung maturity is well established. An enzymatic method that had been automated and optimised for use on a centrifugal analyser was used to measure the total choline containing phospholipids in am...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.11.1304
更新日期:1985-11-01 00:00:00
abstract::One hundred and seventyone antenatal patients were examined for the presence of ;large colony' mycoplasmas in the vagina, and for complement-fixing antibody to Mycoplasma hominis. In 25 patients the findings before and after delivery were compared. In patients from whom M. hominis was grown, antibody was twice as comm...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.4.633
更新日期:1967-07-01 00:00:00
abstract:AIMS:To identify calcifying epithelial odontogenic tumour (CEOT) mutations in oncogenes and tumour suppressor genes. METHODS:A panel of 50 genes commonly mutated in cancer was sequenced in CEOT by next-generation sequencing. Sanger sequencing was used to cover the region of the frameshift deletion identified in one sa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2017-204813
更新日期:2018-03-01 00:00:00
abstract:AIMS:To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones. To demonstrate ...
journal_title:Journal of clinical pathology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jcp.54.1.54
更新日期:2001-01-01 00:00:00
abstract:AIMS:Clot waveform analysis (CWA) has been reported to extend the interpretation of clotting time measurement. The parameters obtained from successive derivatives of the clotting reaction curves reflect the rates of activation of individual coagulation factors, theoretically dissecting the cascade pathway. This study a...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2018-205517
更新日期:2019-03-01 00:00:00
abstract::A method for the differential determination of plasma antithrombins, antithrombin III and alpha2 macroglobulin, is described. The method is based on the selective inactivation of plasma alpha2 macroglobulin by treatment with 0-1 M methylamine for 10 minutes at 37 degrees C and on the observation that antithrombin III ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.1.63
更新日期:1976-01-01 00:00:00
abstract::A technique, using indirect immunoperoxidase antibody (IPA), was developed for the detection of IgG antibody to Chlamydia trachomatis. The IPA technique employs glass slides with air-dried and acetone-fixed C trachomatis infected cells, which can be stored at -70 degrees C and used for several months. Antibody titres ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.3.353
更新日期:1983-03-01 00:00:00