Abstract:
:Poly(ethylenimine) (PEI) has recently emerged as a favorable candidate for nucleic acid (NA) delivery because of its good effectivity at low cost. Despite copious derivatives and formulations being explored over the years, there is a scarcity of efforts to systematically review the current status and unmet needs of related research. The objective of this article is to fill this gap by revisiting the recent advances and challenges in in vivo NA delivery mediated by PEI. For this, related literature was retrieved from PubMed and Web of Science, and among the 530 articles yielded, 49 recent in vivo studies were selected for further analysis. Based on the distillation of literature, implications for research will be drawn and prospects of PEI-mediated NA delivery for stem cell- and RNA-based therapies will be explored. It is hoped that this article could add a new insight to the field and to clinical endeavors in the future.
journal_name
Expert Rev Med Devicesjournal_title
Expert review of medical devicesauthors
Lai WFdoi
10.1586/erd.10.83subject
Has Abstractpub_date
2011-03-01 00:00:00pages
173-85issue
2eissn
1743-4440issn
1745-2422journal_volume
8pub_type
杂志文章,评审abstract::Introduction: Health technology assessments (HTA) are tools for policymaking and resource allocation. Early HTAs are increasingly used in design and development of new technologies. Conducting early HTAs is challenging, due to a lack of evidence and significant uncertainties in the technology and the market. A multi-d...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1743174
更新日期:2020-04-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) is a proven treatment adjunct for selected patients with heart failure and evidence of ventricular dyssynchrony. When applying most contemporary guidelines the accepted response rate has remained static with up to one-third of patients failing to respond. Empiric lateral/postero...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.885320
更新日期:2014-05-01 00:00:00
abstract::In the last decade, bicomponent fibers have been proposed to fabricate bio-inspired systems for tissue repair, regenerative medicine, medical healthcare and clinical applications. In comparison with monocomponent fibers, key advantage concerns their ability of self-adapting to the physiological conditions through an e...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1126505
更新日期:2016-01-01 00:00:00
abstract::Atrial fibrillation is a pervasive and difficult heart rhythm problem for more than 3 million Americans. Patients are plagued by myriad symptoms and are exposed to the risk of stroke. Attempts to restore normal rhythm with drug therapy have been largely unsuccessful and the complications associated with long-term anti...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.09.9
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Total knee arthroplasty (TKA) is one of the most commonly performed orthopedic procedures. During the past decade, patient-specific instrumentation (PSI) has been commercially introduced in order to simplify and make TKA surgery more effective, precise and efficient than conventional mechanical instrumenta...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2019.1627197
更新日期:2019-07-01 00:00:00
abstract::The number and the types of electromagnetic emitters to which patients with active implantable medical devices (AIMD) are exposed to in their daily activities have proliferated over the last decade. Radiofrequency identification (RFID) is an example of wireless technology applied in many fields. The interaction betwee...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.12.5
更新日期:2012-05-01 00:00:00
abstract::To predict the spread of coronavirus disease globally and consequently prepare the hospital facilities with the required technology is a challenge. The availability of essential medical equipment to support patients affected by Covid-19 is globally limited. Areas covered This perspective gives a technical view of the ...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1772757
更新日期:2020-06-01 00:00:00
abstract::The US FDA recognizes that there are many challenges to ensuring that medical devices are used responsibly and safely in the pediatric population. Education plays a key role, and manufacturers and healthcare providers must be informed of medical device issues unique to the pediatric population. Healthcare workers and ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1586/17434440.6.2.131
更新日期:2009-03-01 00:00:00
abstract::Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug d...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1091722
更新日期:2015-01-01 00:00:00
abstract::This paper discusses a new class of robots known as concentric tube robots and their application to transnasal skull base surgery. The endonasal approach has clear benefits for patients, but the surgery presents challenges that strongly motivate the use of robotic tools. In this paper, the concentric tube robot concep...
journal_title:Expert review of medical devices
pub_type: 社论
doi:10.1586/17434440.2013.854702
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Transcatheter devices have contributed significantly to the advances achieved in treating many cardiovascular conditions over the last few decades. Sophisticated and detailed preclinical testing is not only a regulatory requirement to support an investigational device exemption (IDE) application, but more ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2017.1282313
更新日期:2017-02-01 00:00:00
abstract::Left atrial appendage device occlusion for the preventions of systemic thromboembolism and stroke represents a major breakthrough in the field of cardiovascular disease. The wide prevalence of atrial fibrillation with devastating consequences of thromboembolic stroke as a result of thrombus arising from the left atria...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.940315
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Monitoring a patient's vital signs forms a basic component of care, enabling the identification of deteriorating patients and increasing the likelihood of improving patient outcomes. Several paper-based track and trigger warning scores have been developed to allow clinical evaluation of a patient and guida...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2019.1563480
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION:Mechanical circulatory support (MCS) is an increasingly utilized mode of therapy in the management of advanced heart failure, both as bridge to heart transplantation and destination therapy. As MCS becomes more prevalent, it is ever more important to understand the complex hemodynamics of these devices, as...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2017.1324292
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Early promising results of renal nerve denervation awakened interest in developing medical device alternatives for patients with resistant hypertension. The subsequent sham-controlled renal nerve denervation randomized trials were disappointing leading researchers and innovators to explore alternative devi...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1779054
更新日期:2020-07-01 00:00:00
abstract::This article reviews the current status of cochlear implantation in both adults and children, including expanding candidacy groups, bilateral implantation, advances in speech processing software, internal and external device hardware, surgical techniques and outcomes. Promising advances, novel therapies and evolving c...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.11.12
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:Anastomotic leak (AL) after colorectal surgery is a devastating complication; decreased blood perfusion is an important risk factor. Surgeons rely on subjective measures to assess bowel perfusion. Fluorescence imaging (FI) with indocyanine green (ICG) provides a real-time objective assessment of intestinal...
journal_title:Expert review of medical devices
pub_type: 杂志文章,meta分析,评审
doi:10.1080/17434440.2017.1265444
更新日期:2017-01-01 00:00:00
abstract::Conventional ultrasonography represents the first diagnostic imaging modality for the study of pancreatic tumors. Contrast-enhanced ultrasound has significantly improved the accuracy of first-line examination and may influence the choice of second-line investigations: multidetector computed tomography is considered th...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.09.67
更新日期:2010-03-01 00:00:00
abstract::Acute ischemic stroke is caused by occlusion of a cerebral artery, resulting in loss of brain tissue and neurologic deficits. However, a portion of the ischemic brain can be salvaged if blood flow is restored within an appropriate time frame. The past year has seen the publication of five positive randomized controlle...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1143772
更新日期:2016-01-01 00:00:00
abstract::Ventricular assist devices (VAD) are used for mechanical support of the terminally failing heart. Failure of these life supporting systems can be fatal. Early and reliable detection of any upcoming problems is mandatory and is crucial for the outcome. Medical imaging methods are described within this review, which are...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1166051
更新日期:2016-05-01 00:00:00
abstract::Minimally invasive, catheter-based treatment of valvular dysfunction has become an integral part of clinical routine. As left heart valvular disease is much more common and thus commercially of interest, transcatheter solutions for the treatment of aortic and mitral valvular defects were the first to become broadly cl...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.985654
更新日期:2015-03-01 00:00:00
abstract::Glaucoma is a leading cause of blindness worldwide. Currently, topical drops are the mainstay of treatment for patients who suffer from this chronic disease. Adherence to topical therapy is known to be affected by forgetfulness, frequent dosing requirements and physical limitations. Dosing and adherence aids are desig...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.4.2.261
更新日期:2007-03-01 00:00:00
abstract:INTRODUCTION:Historically, patients with rotator cuff arthropathy had limited reconstructive options. The early generations of reverse total shoulder arthroplasty (rTSA) designs had increased failure rates due to loosening of glenoid baseplates secondary to excessive torques. In 1985, Paul Grammont introduced a prosthe...
journal_title:Expert review of medical devices
pub_type: 历史文章,杂志文章,评审
doi:10.1080/17434440.2019.1568237
更新日期:2019-02-01 00:00:00
abstract::Temperature analysis has been considered as a complementary method in medical evaluation and diagnosis. Several studies demonstrated that monitoring the temperature variations of the feet of diabetic patients can be helpful in the early identification of diabetic foot manifestations, and also in changing behaviors, wh...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1032251
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:Funding for scientific advancement comes from two dominant sources: public funds used to generate knowledge, and private sector funds in the pursuit of commercial products. It is unclear how to compare the outputs of these two financial mechanisms because both sectors are motivated by common goods but are ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2018.1419866
更新日期:2018-02-01 00:00:00
abstract::Neurodegeneration in Parkinson's disease (PD) affects both the fine motor control of the fingers and gross movement of the upper limb. Handwriting examinations are commonly performed in the analysis of tremor in PD and there is validity in subjective assessment in the clinic. However, there is clinical need for a more...
journal_title:Expert review of medical devices
pub_type: 社论,评审
doi:10.1586/17434440.2014.900437
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:With optical coherence tomography (OCT), details of arterial injuries during percutaneous coronary intervention can be assessed accurately. There might be an increased risk of stent edge dissections with the novel delivery system for the STENTYS stent. We evaluated the prevalence of stent edge dissections us...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2018.1421942
更新日期:2018-02-01 00:00:00
abstract::In the last 30 years, development of minimally invasive percutaneous procedures to treat cardiovascular defects has been thriving. Although these techniques present obvious advantages, like avoiding cardiopulmonary bypass, the passage of catheter systems and the deployment of devices in the blood circulation can cause...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1120666
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Stent-assisted coiling (SAC) has widened indications of endovascular treatment of intracranial aneurysms (wide-neck, fusiform aneurysms); moreover, it is associated with more stable anatomical results. Besides the development of other techniques such as flow diverter stents, bifurcation stents, or intrasac...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2018.1538779
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Since the advent of peritoneal dialysis (PD) in the 1970s, the principles of dialysis have changed little. In the coming decades, several major breakthroughs are expected. AREAS COVERED:Novel wearable and portable dialysis devices for both hemodialysis (HD) and PD are expected first. The HD devices could ...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2018.1462697
更新日期:2018-05-01 00:00:00