Abstract:
BACKGROUND:Previous studies have found individuals with family histories of alcohol use disorders are more impulsive on some but not all laboratory behavioral measures, suggesting deficits on specific forms of impulse control. However, drawing conclusions is tenuous because these different measures have not been administered together in the same group of participants. METHODS:In the present study, we compared healthy 21-35 year old adults with family histories of alcohol related problems (FHAP+) or without such histories (FHAP-) on behavioral measures of response inhibition, response initiation, and consequence sensitivity impulsivity. FHAP+ (n=36) and FHAP- (n=36) participants were compared on performance on the Immediate Memory Task (IMT, response initiation), GoStop Impulsivity Paradigm (GoStop, response inhibition), Two Choice Impulsivity Paradigm (TCIP, consequence sensitivity) and Single Key Impulsivity Paradigm (SKIP, consequence sensitivity). RESULTS:FHAP+ individuals were more impulsive on the IMT and GoStop but not on the TCIP or SKIP. CONCLUSIONS:These results suggest that response initiation and response inhibition impulsivity are increased in individuals with family histories of alcohol related problems despite not having alcohol or drug use disorders themselves. In contrast, increased consequence sensitivity impulsivity may be associated with additional risk factors such as more severe family histories of alcohol use disorders, or it may be increased as a consequence of heavy drug or alcohol use.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Acheson A,Richard DM,Mathias CW,Dougherty DMdoi
10.1016/j.drugalcdep.2011.02.001subject
Has Abstractpub_date
2011-09-01 00:00:00pages
198-203issue
2-3eissn
0376-8716issn
1879-0046pii
S0376-8716(11)00085-8journal_volume
117pub_type
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更新日期:2006-09-01 00:00:00
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更新日期:1990-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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更新日期:2003-07-20 00:00:00
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pub_type: 杂志文章
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