The alterations in neurotransmitters and their metabolites in discrete brain regions in the rats after inhalation of disinfectant, glutaraldehyde or ortho-phthalaldehyde for 4 weeks.

Abstract:

:Glutaraldehyde (GA) and ortho-phtalaldehyde (OPA) have been widely used as major components of disinfectants in hospitals. We evaluated the alterations in GA or OPA in rats after subacute inhalation exposure by determining levels of neurotransmitters (norepinephrine [NE], dopamine [DA], DA metabolites, dihydroxyphenylacetic acid [DOPAC] and homovanillic acid [HVA], indoleamine serotonin [5-HT] and 5-HT metabolite, 5-hydroxyindoleacetic acid [5-HIAA]) in discrete brain regions using high performance liquid chromatography (HPLC) equipped with an electrochemical detector. Female Wistar rats were exposed to 0, 50, 100, or 200 ppb gaseous GA or OPA by inhalation for 1 h per day, 5 d per week for 4 wk. Following the exposure, the brain of each rat was removed and dissected into cerebrum, cerebellum, medulla oblongata, midbrain, corpus striatum and hypothalamus. The neurotransmitters and their metabolites were extracted from each brain region, and determined by HPLC. Regarding GA, the daily water intake of the 50 or the 200 ppb exposed groups was significantly lower than that of the control. DA and 5-HIAA levels in the medulla oblongata among the GA exposed groups were significantly lower than those of the control. For OPA, the mean final body weight and daily food intake of the 100 or 200 ppb exposed groups were significantly lower than those of the control. The mean DA concentrations in the cerebrum in the groups exposed to OPA were significantly lower than those of the control. OPA may modulate DA metabolism in the cerebrum of female rats. The levels GA or OPA that induced alienations in neurotransmitters were comparable to those levels usually found in hospitals, further studies are warranted to evaluate the of safety of disinfectants containing GA or OPA.

journal_name

Ind Health

journal_title

Industrial health

authors

Katagiri H,Yamamoto T,Uchimura A,Tsunoda M,Aizawa Y,Yamauchi H

doi

10.2486/indhealth.ms1156

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

328-37

issue

3

eissn

0019-8366

issn

1880-8026

pii

JST.JSTAGE/indhealth/MS1156

journal_volume

49

pub_type

杂志文章
  • Relationship between chest X-ray findings and pulmonary function tests in dust workers.

    abstract::Occupational injuries are decreasing due to the improvement in occupational management in the workplace in recent years. However, pneumoconiosis and its complications remain important occupational diseases. Based on the report 'survey on classification for supervision of pneumoconiosis in Japan' performed in 1994, thi...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.43.256

    authors: Tonori Y,Niitsuya M,Sato T,Sugiura Y,Miyake H,Aizawa Y

    更新日期:2005-01-01 00:00:00

  • Precarious employment and health: analysis of the Comprehensive National Survey in Japan.

    abstract::Recent studies suggest that unstable employment contracts may affect the health of workers. Many Japanese workers working full time in ostensibly permanent positions actually operate within unstable and precarious employment conditions. We compared the health status of Japanese workers with precarious employment contr...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.ms1260

    authors: Tsurugano S,Inoue M,Yano E

    更新日期:2012-01-01 00:00:00

  • Increase of olfactory threshold in plating factory workers exposed to chromium in Korea.

    abstract::To disclose the effects of chromium (Cr) on olfactory function, olfactory threshold tests were conducted on 27 male plating workers (Cr workers) with signs and symptoms of olfactory irritation but without nasal septum perforation or ulcer and on 34 male control subjects in Korean plating factories. The Cr workers had ...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.41.279

    authors: Kitamura F,Yokoyama K,Araki S,Nishikitani M,Choi JW,Yum YT,Park HC,Park SH,Sato H

    更新日期:2003-07-01 00:00:00

  • Effects of box handle position and carrying range on bi-manual carrying capacity for females.

    abstract::This study utilizes a psychophysical approach to examine the effects on carrying capacity for bi-manual carrying tasks involving different handle positions and carrying ranges. A total of 16 female subjects participated in the experiment in groups of two people, and each group of subjects performed the tasks in a rand...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2014-0244

    authors: Wu SP,Loiu Y,Chien TH

    更新日期:2015-01-01 00:00:00

  • Development and evaluation of a new push-pull ventilation system for sheet-adhesive work inside bus-body.

    abstract::We present the performance of a new push-pull ventilation system for sheet-adhesive work inside the body of a sightseeing coach. The target sightseeing coach was 12 m long, 2.5 m wide and 2 m high from floor to ceiling. We made a prototype of an airflow system and a half-scale model of the bus-body. The half scale mod...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.41.24

    authors: Yotsumoto H,Hayakawa Y,Myojo T

    更新日期:2003-01-01 00:00:00

  • Effect of working hours on cardiovascular-autonomic nervous functions in engineers in an electronics manufacturing company.

    abstract::A field survey of 147 engineers (23-49 years) in an electronics manufacturing company was conducted to investigate the effect of working hours on cardiovascular-autonomic nervous functions (urinary catecholamines, heart rate variability and blood pressure). The subjects were divided into 3 groups by age: 23-29 (n = 49...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.37.55

    authors: Sasaki T,Iwasaki K,Oka T,Hisanaga N,Ueda T,Takada Y,Fujiki Y

    更新日期:1999-01-01 00:00:00

  • Workaholism and negative work-related incidents among nurses.

    abstract::The present study comprised 1,781 nurses who participated in an investigation about working conditions, sleep, and health. They answered a questionnaire about age, sex, marital status, children living at home, work hours per week, number of night shifts last year, and total sleep duration and that also included a vali...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2017-0223

    authors: Andreassen CS,Pallesen S,Moen BE,Bjorvatn B,Waage S,Schaufeli WB

    更新日期:2018-10-03 00:00:00

  • Reversible lung lesions in rats due to short-term exposure to ultrafine cobalt particles.

    abstract::Using an ultrasonic nebulizer, cobalt aerosols (MMAD = 0.76 microns, sigma g = 2.1) were generated from an aqueous suspension of ultrafine metallic cobalt particles (Uf-Co) with a primary diameter of 20 nm. Rats were exposed to Uf-Co aerosols at 2.72 +/- 0.44 mg/m3 for 5 hours (Exp. 1) or at 2.12 +/- 0.55 mg/m3 for 4 ...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.30.103

    authors: Kyono H,Kusaka Y,Homma K,Kubota H,Endo-Ichikawa Y

    更新日期:1992-01-01 00:00:00

  • Maximum acceptable weight of manual load carriage for young Taiwanese males.

    abstract::This study examined the maximum acceptable weight of carriage (MAWC) for young Taiwanese males experienced in manual load carriage tasks. The elements of the examined load carriage tasks included lifting a box from the floor to the waist height, turning around while holding the box, carrying the box at the waist heigh...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.44.200

    authors: Cheng TS,Lee TH

    更新日期:2006-01-01 00:00:00

  • Development of vibration protection seats for agricultural machinery.

    abstract::Seats have been newly developed with an anti-vibration suspension system for agricultural machinery. These seats were examined in a series of laboratory tests to determine their static and dynamic physical characteristics. These seats are specifically designed for the Japanese physique. An artificial track was constru...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.36.133

    authors: Ishikawa F

    更新日期:1998-04-01 00:00:00

  • Self-awakening prevents acute rise in blood pressure and heart rate at the time of awakening in elderly people.

    abstract::Self-awakening, waking up at a designated time decided before sleeping, could prevent failure in the blood circulation vessel system such as heart attack, acute increases in heart rate or blood pressure upon waking. Previous research showed that anticipatory changes occurred in heart rate prior to awakening from a sho...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.43.179

    authors: Kaida K,Ogawa K,Hayashi M,Hori T

    更新日期:2005-01-01 00:00:00

  • Exposure reconstruction of trichloroethylene among patients with occupational trichloroethylene hypersensitivity syndrome.

    abstract::Occupational trichloroethylene (TCE) exposure can induce life-threatening generalized dermatitis accompanied by hepatitis: TCE hypersensitivity syndrome (HS). Since the patients' exposure levels have not been fully clarified, this study estimated end-of-shift urinary concentrations of trichloroacetic acid (TCA) and th...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2017-0202

    authors: Nakajima T,Wang H,Ito Y,Naito H,Wang D,Zhao N,Li H,Qiu X,Xia L,Chen J,Wu Q,Li L,Huang H,Kamijima M

    更新日期:2018-07-27 00:00:00

  • Early intervention mechanism for preventing electrocution in construction engineering.

    abstract::The aim of this study is to establish an effective early intervention mechanism for construction engineering to prevent electrocution while improving labor safety and reducing the casualty risk. This study used narrative text analysis and the Haddon Matrix for data collection, and analyzed the causes from the 113 elec...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2020-0097

    authors: Shiau YR,Lo FY,Ko PC

    更新日期:2020-10-03 00:00:00

  • Influence of 2-bromopropane on reproductive system--2-bromopropane inhibits forced ovulation in mice.

    abstract::The influence of 2-bromopropane, an alternative to freon, on ovulation was examined using superovulation induced by pregnant mare's serum gonadotropin and human chorionic gonadotropin (PMSG-hCG) treatment. Three groups of mice were injected intraperitoneally 8 times with 2-bromopropane (2-BP) at 500, 1,000 or 2,000 mg...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.36.297

    authors: Sekiguchi S,Honma T

    更新日期:1998-07-01 00:00:00

  • Sleep polysomnography and reported stress across 6 weeks.

    abstract::Despite the common notion that stress impairs sleep there is little published data showing that sleep (polysomnography (PSG)) is impaired across several sleep episodes in individuals who complain of daily stress during the same period. The present paper aimed at investigating such a connection. 33 subjects had 3 sleep...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2013-0169

    authors: Åkerstedt T,Lekander M,Petersén H,Kecklund G,Axelsson J

    更新日期:2014-01-01 00:00:00

  • Perceptions of the impact of non-standard work schedules on health in Australian graduates: an exploratory study.

    abstract::Non-standard working hours are associated with negative health outcomes. However, little is known about the early years of exposure to non-standard work hours, or whether workers new to these work schedules perceive their work as impacting their health. This limits our ability to develop meaningful intervention strate...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2019-0036

    authors: Crowther ME,Reynolds AC,Ferguson SA,Adams R

    更新日期:2020-02-04 00:00:00

  • Decreases in CD8+ T, naive (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume.

    abstract::To examine the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men, T lymphocyte subpopulations, B (CD19+) lymphocytes, natural killer (NK) cells, and serum immunoglobulins (i.e., IgG, IgA and IgM) together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood ...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.44.592

    authors: Nakata A,Araki S,Park SH,Park JT,Kim DS,Park HC,Yokoyama K

    更新日期:2006-10-01 00:00:00

  • Relationship between work-related accidents and hot weather conditions in Tuscany (central Italy).

    abstract::Nowadays, no studies have been published on the relationship between meteorological conditions and work-related mortality and morbidity in Italy. The aim of this study was to evaluate the relationship between hot weather conditions and hospital admissions due to work-related accidents in Tuscany (central Italy) over t...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.44.458

    authors: Morabito M,Cecchi L,Crisci A,Modesti PA,Orlandini S

    更新日期:2006-07-01 00:00:00

  • Combination of parity and pre-pregnancy BMI and low birth weight infants among Japanese women of reproductive age.

    abstract::This study aimed to examine the effects of parity and pre-pregnancy body mass index (BMI) on low birth weight (LBW) infants among Japanese women. Participants included 1,518 mothers (mean age 34.0 years) of singleton full-term infants in 2011. The incidence of LBW infants was 7.5% in primiparous women with BMI<18.5 (G...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2016-0088

    authors: Suzuki K,Nomura K,Takenoshita S,Ando K,Kido M

    更新日期:2016-12-07 00:00:00

  • Minnesota nurses' study: perceptions of violence and the work environment.

    abstract::Work-related violence is an important problem worldwide, and nurses are at increased risk. This study identified rates of violence against nurses in Minnesota, USA, and their perceptions of the work environment. A sample of 6,300 randomly selected nurses described their experience with work-related violence in the pre...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.45.672

    authors: Nachreiner NM,Gerberich SG,Ryan AD,McGovern PM

    更新日期:2007-10-01 00:00:00

  • Chemical exposures in research laboratories in a university.

    abstract::Research laboratories in a university were investigated for air-borne levels of legally designated organic solvents and specified chemical substances. Repeated surveys in 2004-5 (four times in the two years) of about 720 laboratories (thus 2,874 laboratories in total) revealed that the solvent concentrations were in e...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.46.166

    authors: Takada S,Okamoto S,Yamada C,Ukai H,Samoto H,Ohashi F,Ikeda M

    更新日期:2008-04-01 00:00:00

  • Sleep-related risk of occupational injuries in Japanese small and medium-scale enterprises.

    abstract::A cross-sectional study evaluated the contribution of daily sleep habits to occupational injuries. A self-administered questionnaire solicited answers about sleep, symptoms of depression, occupational injury, demographics, presence of diseases and lifestyle factors from 2,903 workers between the ages of 16-83 (mean 45...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.43.89

    authors: Nakata A,Ikeda T,Takahashi M,Haratani T,Fujioka Y,Fukui S,Swanson NG,Hojou M,Araki S

    更新日期:2005-01-01 00:00:00

  • Effects of carbosulfan administration schedules on estrous cycle and follicular dynamics in albino mice.

    abstract::Carbosulfan an acaricide was orally administrated at 48 mg/kg body weight/day to female swiss albino mice for 5, 10, 20 and 30 d. Daily vaginal smear and body weight was recorded. The mice were sacrificed by cervical dislocation after 24 h of terminal exposure to carbosulfan. The results of the present study indicated...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.46.210

    authors: Ksheerasagar RL,Kaliwal BB

    更新日期:2008-07-01 00:00:00

  • A prospective observation of onsets of health defects associated with working hours.

    abstract::A prospective study examined whether working 50 hours or less per week was associated with an increase of mental and circulatory disorders, and if so, whether it was significant for managing workers' health. White-collar workers aged 20 to 60 working at an office of a Japanese company were surveyed from August 1997 to...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.41.101

    authors: Tarumi K,Hagihara A,Morimoto K

    更新日期:2003-04-01 00:00:00

  • Towards a more comprehensive definition of shift work tolerance.

    abstract::The aim of the present study was to define the nature of individual differences in shift work tolerance (SWT). This was investigated by an exploratory factor analysis of scores from a wide range of established instruments designed to measure sleep, sleepiness, fatigue, social functioning, as well as physical and menta...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2014-0112

    authors: Saksvik-Lehouillier I,Pallesen S,Bjorvatn B,Magerøy N,Folkard S

    更新日期:2015-01-01 00:00:00

  • Advances in participatory occupational health aimed at good practices in small enterprises and the informal sector.

    abstract::Participatory programmes for occupational risk reduction are gaining importance particularly in small workplaces in both industrially developing and developed countries. To discuss the types of effective support, participatory steps commonly seen in our "work improvement-Asia" network are reviewed. The review covered ...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.44.31

    authors: Kogi K

    更新日期:2006-01-01 00:00:00

  • Barefoot-pedestrian tribometry: in vivo method of measurement of available friction between the human heel and the walkway.

    abstract::We have developed an in vivo tribometer for characterizing the friction of a human heel against a planar test surface. The pedestrian steps down on an angled test surface and an observer determines if the person's heel slips. In the simplest variation, the subject simply steps down onto the test surface. The second va...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.46.51

    authors: Besser M,Marpet M,Medoff H

    更新日期:2008-01-01 00:00:00

  • A simple direct injection method for GC/MS analysis of PAHs in particulate matter.

    abstract::A simple direct injection method for analysis of polycyclic aromatic hydrocarbons (PAHs) or other organic components of particulate matter by gas chromatography/mass spectrometry (GC/MS) was developed. This method uses a small custom brass capsule to insert a particulate sample deposited on a quartz fiber filter or po...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.46.582

    authors: Ono-Ogasawara M,Myojo T,Smith TJ

    更新日期:2008-12-01 00:00:00

  • Prevalence characteristics and prediction of coal workers' pneumoconiosis in the Tiefa Colliery in China.

    abstract::To explore characteristics of the development of coal workers' pneumoconiosis (CWP) at present and trend in the future, we investigated 16,154 coal miners exposed to dust for at least 1 yr in the Tiefa Colliery in China. Occupational categories were divided into tunneling, mining, combining and helping. Four cohorts (...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.47.369

    authors: Liu H,Tang Z,Weng D,Yang Y,Tian L,Duan Z,Chen J

    更新日期:2009-08-01 00:00:00

  • Relationship between depressive symptoms and perceived individual level occupational stress among Japanese schoolteachers.

    abstract::Japanese teachers are mentally and physically burdened with various work stressors. This cross-sectional study examined the relationship between depressive symptoms and perceived individual level occupational stress including role problems among Japanese schoolteachers. This study included 1,006 teachers working in pu...

    journal_title:Industrial health

    pub_type: 杂志文章

    doi:10.2486/indhealth.2015-0195

    authors: Nakada A,Iwasaki S,Kanchika M,Nakao T,Deguchi Y,Konishi A,Ishimoto H,Inoue K

    更新日期:2016-10-08 00:00:00