Effects of carbosulfan administration schedules on estrous cycle and follicular dynamics in albino mice.

Abstract:

:Carbosulfan an acaricide was orally administrated at 48 mg/kg body weight/day to female swiss albino mice for 5, 10, 20 and 30 d. Daily vaginal smear and body weight was recorded. The mice were sacrificed by cervical dislocation after 24 h of terminal exposure to carbosulfan. The results of the present study indicated that there was a significant decrease in the number of estrous cycle and phases with a concomitant increase in the length of the estrous cycle and diestrus phase with carbosulfan treatment for 10, 20, and 30 d. There was a significant decrease in the weight of the ovary, uterus, number of healthy follicles and increase in the number of atretic follicles with 20 and 30 d carbosulfan treatment when compared with the control. There was a significant decrease in the level of sialic acid with an increase in the level of cholesterol by carbosulfan treatment for 20 and 30 d. The decreased level of sialic acid indicates the decreased level of circulating FSH/LH. The ovary 3beta HSD activity decreased significantly with 20 and 30 d carbosulfan exposure mice indicating its effect on steroidogenesis, when compared to controls. The above findings may be due to direct effect on the ovary or on the gonadotrophins secretion via central nervous mechanism in mice.

journal_name

Ind Health

journal_title

Industrial health

authors

Ksheerasagar RL,Kaliwal BB

doi

10.2486/indhealth.46.210

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

210-6

issue

3

eissn

0019-8366

issn

1880-8026

pii

JST.JSTAGE/indhealth/46.210

journal_volume

46

pub_type

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