Influence of 2-bromopropane on reproductive system--2-bromopropane inhibits forced ovulation in mice.

Abstract:

:The influence of 2-bromopropane, an alternative to freon, on ovulation was examined using superovulation induced by pregnant mare's serum gonadotropin and human chorionic gonadotropin (PMSG-hCG) treatment. Three groups of mice were injected intraperitoneally 8 times with 2-bromopropane (2-BP) at 500, 1,000 or 2,000 mg/kg and were induced to ovulate by PMSG-hCG treatment. Injection of 2-BP caused the number of ovulated ova in the 1,000 mg/kg and 2,000 mg/kg groups to decrease remarkably. Uterus weight was also decreased in the 2,000 mg/kg group on the terminal day of the experiment. This result was consistent with cases of human intoxication in which reproductive toxicity was observed.

journal_name

Ind Health

journal_title

Industrial health

authors

Sekiguchi S,Honma T

doi

10.2486/indhealth.36.297

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

297-9

issue

3

eissn

0019-8366

issn

1880-8026

journal_volume

36

pub_type

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