Abstract:
:The serotonin transporter promoter region polymorphism (5-HTTLPR) is associated with neural response to negative images in brain regions involved in the experience of emotion. However, the behavioral implications of this sensitivity have been studied far less extensively. The current study used eye-tracking methodology to examine how individuals genotyped for the 5-HTTLPR, including the single nucleotide polymorphism (SNP) rs25531, allocated attention during prolonged (30-s) exposure to face stimuli depicting positive and negative emotion. Short 5-HTTLPR allele carriers and carriers of the long allele with guanine at the sixth nucleotide (S/LG) displayed a stronger gaze bias (total fixation time, number of fixations, mean fixation length) for positive than for sad, threat, or neutral stimuli. In contrast, those homozygous for the long 5-HTTLPR allele with adenine at the sixth nucleotide (LA) viewed the emotion stimuli in an unbiased fashion. Time course analyses indicated no initial 5-HTTLPR group differences; however, S/LG 5-HTTLPR allele carriers were more likely than LA 5-HTTLPR homozygotes to direct gaze toward happy than toward sad stimuli over time. This bias toward positive stimuli during the later stages of information processing likely reflects a strategic effort to downregulate heightened reactivity to negative stimuli among 5-HTTLPR S/LG allele carriers.
journal_name
J Abnorm Psycholjournal_title
Journal of abnormal psychologyauthors
Beevers CG,Marti CN,Lee HJ,Stote DL,Ferrell RE,Hariri AR,Telch MJdoi
10.1037/a0022125subject
Has Abstractpub_date
2011-02-01 00:00:00pages
187-97issue
1eissn
0021-843Xissn
1939-1846pii
2011-00349-001journal_volume
120pub_type
杂志文章abstract::A discrete-time survival analysis of recovery from major depressive episodes for a sample of married subjects (N = 119) identified several significant predictors of recovery including comorbidity for anxiety disorders or substance abuse, social support, age, and education. Furthermore, the analysis distinguished betwe...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.101.2.277
更新日期:1992-05-01 00:00:00
abstract::A stressor vulnerability model of stress-induced drinking was tested in a stratified random sample of 1,316 Black and White adult drinkers. Stressors were highly predictive of both alcohol use and drinking problems among men who relied on avoidant forms of emotion coping or held strong positive expectancies for alcoho...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.101.1.139
更新日期:1992-02-01 00:00:00
abstract::Problematic alcohol involvement typically peaks in the early 20s and declines with age. This maturing out of alcohol involvement is usually attributed to individuals attaining adult statuses incompatible with heavy drinking. Nevertheless, little is known about how changes in problematic alcohol use during emerging/ear...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0015125
更新日期:2009-05-01 00:00:00
abstract::Two fear-relevant imagery scripts were used as conditioned stimuli (CSs) in a differential learning paradigm with 5.5% CO2-enriched air as unconditioned stimulus (US). In another condition, 2 neutral scripts were used as CSs (N = 56). Within each condition, one script was imagined while breathing the CO2-enriched air ...
journal_title:Journal of abnormal psychology
pub_type: 临床试验,杂志文章
doi:10.1037//0021-843x.108.1.143
更新日期:1999-02-01 00:00:00
abstract::A national sample of 60 male and 61 female adults completed a telephone interview that included measures of hypochondriacal tendencies, psychological distress, and symptom manifestation. They also provided cognitive evaluations for their most important health goal on scales measuring self-efficacy, value, planning, se...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.105.1.42
更新日期:1996-02-01 00:00:00
abstract::There is considerable concern about the adjustment of children of depressed mothers. Earlier we studied the specificity of these difficulties to maternal depression. Child adjustment difficulties were evident in 7- to 13-year-old children of both depressed and nondepressed psychiatric patient mothers but not in the ch...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.100.4.473
更新日期:1991-11-01 00:00:00
abstract::Empathy deficits feature prominently in theoretical accounts of psychopathy, yet studies that have examined various aspects of emotional processing related to empathy have produced a mixed body of findings. We created a laboratory measure of cognitive empathy based on the empathic accuracy paradigm (i.e., the ability ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0030261
更新日期:2013-02-01 00:00:00
abstract::Three studies were conducted to compare the ability of a measure of fear of physical sensations (Anxiety Sensitivity Index; ASI) and a measure of trait anxiety (State-Trait Anxiety Inventory; STAI) to predict response to hyperventilation. In the first study subjects (N = 43) were selected who differed in scores on the...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.103.4.693
更新日期:1994-11-01 00:00:00
abstract::Working memory (WM) was studied in 82 healthy volunteers, 43 schizophrenia patients, and 81 bipolar patients. Schizophrenia patients were impaired on verbal and figural WM tasks that possessed similar test discriminating power. Bipolar patients performed similarly to healthy volunteers. A mathematical model of WM perf...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.116.4.741
更新日期:2007-11-01 00:00:00
abstract::We find Brewin's (2016) critiques of the narratives, power, and coherence measures in Rubin et al. (2016) without merit; his suggestions for a "revised formulation" (p. 1015) of coherence are contradicted by data readily available in the target article but ignored. We place Brewin's commentary in a historical context ...
journal_title:Journal of abnormal psychology
pub_type: 评论,杂志文章
doi:10.1037/abn0000211
更新日期:2016-10-01 00:00:00
abstract::Despite the absence of a consensual definition of disorder, considerable research and clinical work is based on the categorization and diagnosis of mental disorder. This article introduces a special section of the Journal of Abnormal Psychology that expands the debate between J. C. Wakefield (1999), who has proposed a...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.108.3.371
更新日期:1999-08-01 00:00:00
abstract::[Correction Notice: An Erratum for this article was reported in Vol 126(2) of Journal of Abnormal Psychology (see record 2016-56318-001). In the article, Figure 1 had incorrect axis labels. There was also an error in the abstract, which did not state that ΔFN was calculated as FN to losses minus FN to gains. All versi...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000237
更新日期:2017-02-01 00:00:00
abstract::The authors sought to define the latent factors associated with childhood anxiety and depression, using a structural equations/confirmatory factor-analytic approach involving multiple informants (i.e., parent and child report) of symptoms. A sample of 216 children and adolescents with diagnoses of an anxiety disorder ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.107.1.74
更新日期:1998-02-01 00:00:00
abstract::Two studies explored which different dimensions of schizotypal personality disorder (SPD) were associated with negative affect, attention to emotions, clarity of emotions, and emotional intensity/instability. Study 1 included 247 college students, and questionnaires were used to measure SPD. Study 2 included 225 commu...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.115.2.359
更新日期:2006-05-01 00:00:00
abstract::Borderline personality disorder (BPD) is thought to develop by early adulthood, and it is characterized by lack of control of anger, intense and frequent mood changes, impulsive acts, disturbed interpersonal relationships, and life-threatening behaviors. We describe data from a 2-year follow-up study of nonclinical yo...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.106.2.307
更新日期:1997-05-01 00:00:00
abstract::A number of studies have indicated that social support is associated with the course of depression. However, none of these studies have ruled out the potentially confounding effects of personality factors, such as neuroticism. The authors examined whether social support was related to the course of depression after co...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.106.3.478
更新日期:1997-08-01 00:00:00
abstract::Individuals with autism spectrum disorder (ASD) often display enhanced attention to detail and exhibit restricted behavior. However, due to a lack of comprehensive eye-movement modeling techniques, it is currently unknown whether these behavioral effects are also evident during scene viewing (i.e., detailed visual ins...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000145
更新日期:2016-04-01 00:00:00
abstract::In a previous article, we demonstrated in a large twin study that disordered gambling (DG), as defined by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV), ran in families, that about half of the variation in liability for DG was due to familial factors, and that all of this was explained by...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0022879
更新日期:2011-08-01 00:00:00
abstract::Self-discrepancy theory proposes that anxiety and depression are the result of different types of conflicting self-beliefs. This study examined self-discrepancies in four groups of university students who completed a questionnaire assessing levels of self-discrepancy and were characterized by the following disorders: ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.102.2.282
更新日期:1993-05-01 00:00:00
abstract::The search for genes involved in autism spectrum conditions (ASC) may have been hindered by the assumption that the different symptoms that define the condition can be attributed to the same causal mechanism. Instead the social and nonsocial aspects of ASC may have distinct causes at genetic, cognitive, and neural lev...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0031919
更新日期:2013-05-01 00:00:00
abstract::The authors examined the reciprocal relations between rumination and symptoms of depression, bulimia, and substance abuse with longitudinal data from 496 female adolescents. Rumination predicted future increases in bulimic and substance abuse symptoms, as well as onset of major depression, binge eating, and substance ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.116.1.198
更新日期:2007-02-01 00:00:00
abstract::Cortisol is elevated during severe depression. However, some studies of outpatients suggest reduced cortisol levels, either basal or poststress. More definite evidence of this phenomenon is needed, and correlates that may explain the disparate findings should be identified. Women from the community (37 depressed and 3...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.114.4.697
更新日期:2005-11-01 00:00:00
abstract::Research has suggested the existence of a pathological dissociative taxon. However, relatively little is known about this taxon. This study examined the 2-month retest stability of this taxon--together with other measures of dissociation and the Big Five--in a sample of 465 undergraduates. Contrary to expectation, tax...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843x.112.2.298
更新日期:2003-05-01 00:00:00
abstract::The current study prospectively examined the impact of social support on symptom severity and recovery from episodes in bipolar disorder, both as a direct influence and as a buffer of life events. Fifty-nine individuals with Bipolar I disorder were followed longitudinally with monthly symptom severity interviews. Soci...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.108.4.558
更新日期:1999-11-01 00:00:00
abstract::Two experiments were conducted to examine the effect of stress on hedonic capacity. In Experiment 1, cadets in the U.S. Army Reserve Officer Training Corps reported experiencing less pleasure while watching amusing film clips after participating in a weekend of field training exercises than they did on a control day. ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.102.3.474
更新日期:1993-08-01 00:00:00
abstract::We measured the reaction times (RTs) of schizophrenic (n = 25), matched normal (n = 69), and bipolar (n = 14) subjects to a tone preceded by a preparatory interval (PI; the time between the warning signal and imperative stimulus) of varying length. RTs increase when the PI for the immediately preceding trial (the PPI)...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.102.1.145
更新日期:1993-02-01 00:00:00
abstract::Articulating an accurate and clinically useful structure of psychopathology is a crucial and difficult task. Dimensions identified through cross-sectional factor analyses are increasingly being linked with temporally dynamic processes of social cognition, emotion regulation, symptom expression, and functional impairme...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000177
更新日期:2016-11-01 00:00:00
abstract::Marriage and parenthood are associated with alcohol use and use disorder (AUD), although they are confounded such that many studies struggle to identify their unique and/or causal effects. The present study utilized a genetically informed discordant twin design that strengthens the putative causal role of marital and ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000611
更新日期:2020-10-01 00:00:00
abstract::Anxiety sensitivity (AS) has been defined as the fear of anxiety and anxiety-related sensations, and evidence suggests that AS plays an important role in the psychopathology of panic. It is entirely unclear whether the relation between AS and panic should be attributed to one (or more) of the AS group factors, the gen...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.110.3.372
更新日期:2001-08-01 00:00:00
abstract::Although stability and pervasive inflexibility are general criteria for Diagnostic and Statistical Manual of Mental Disorders, 4th edition (American Psychiatric Association, 1994) personality disorders (PDs), borderline PD (BPD) is characterized by instability in several domains, including interpersonal behavior, affe...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0016954
更新日期:2009-11-01 00:00:00