UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.

abstract：:"Lipid raft" is the name given to the tiny, dynamic, and ordered domains of cholesterol and sphingolipids that are hypothesized to exist in the plasma membranes of eukaryotic cells. According to the lipid raft hypothesis, these cholesterol- and sphingolipid-enriched domains modulate the protein-protein interactions th...

journal_title：Molecular biology of the cell

authors： Kraft ML

更新日期：2013-09-01 00:00:00

abstract：:In the phagocytic cell, NADPH oxidase (Nox2) system, cytoplasmic regulators (p47(phox), p67(phox), p40(phox), and Rac) translocate and associate with the membrane-spanning flavocytochrome b(558), leading to activation of superoxide production. We examined membrane targeting of phox proteins and explored conformational...

journal_title：Molecular biology of the cell

authors： Ueyama T,Tatsuno T,Kawasaki T,Tsujibe S,Shirai Y,Sumimoto H,Leto TL,Saito N

更新日期：2007-02-01 00:00:00

abstract：:The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin cytoskeleton by regulating the Rho family of small GTPases. The signaling events that mediate changes in the activity of Rho proteins in response to the extracellular matrix remain largely unknown. We have demonstrated in pr...

journal_title：Molecular biology of the cell

authors： Arthur WT,Burridge K

更新日期：2001-09-01 00:00:00

abstract：:Insulin maintains whole body blood glucose homeostasis, in part, by regulating the amount of the GLUT4 glucose transporter on the cell surface of fat and muscle cells. Insulin induces the redistribution of GLUT4 from intracellular compartments to the plasma membrane, by stimulating a large increase in exocytosis and a...

journal_title：Molecular biology of the cell

authors： Zeigerer A,McBrayer MK,McGraw TE

更新日期：2004-10-01 00:00:00

abstract：:Cell migration is a highly conserved process involving cytoskeletal reorganization and restructuring of the surrounding extracellular matrix. Although there are many studies describing mechanisms underlying cell motility, little has been reported about the contribution of alternative isoform use toward cell migration....

journal_title：Molecular biology of the cell

authors： Lee HN,Mitra M,Bosompra O,Corney DC,Johnson EL,Rashed N,Ho LD,Coller HA

更新日期：2018-08-01 00:00:00

abstract：:In mammalian cells, the inheritance of the Golgi apparatus into the daughter cells during each cycle of cell division is mediated by a disassembly and reassembly process, and this process is precisely controlled by phosphorylation and ubiquitination. VCIP135 (valosin-containing protein p97/p47 complex-interacting prot...

journal_title：Molecular biology of the cell

authors： Zhang X,Wang Y

更新日期：2015-06-15 00:00:00

abstract：:The auxilin family of J-domain proteins load Hsp70 onto clathrin-coated vesicles (CCVs) to drive uncoating. In vitro, auxilin function requires its ability to bind clathrin and stimulate Hsp70 ATPase activity via its J-domain. To test these requirements in vivo, we performed a mutational analysis of Swa2p, the yeast a...

journal_title：Molecular biology of the cell

authors： Xiao J,Kim LS,Graham TR

更新日期：2006-07-01 00:00:00

abstract：:Timely down-regulation of the evolutionarily conserved protein kinase Swe1 plays an important role in cell cycle control, as Swe1 can block nuclear division through inhibitory phosphorylation of the catalytic subunit of cyclin-dependent kinase. In particular, Swe1 degradation is important for budding yeast cell surviv...

journal_title：Molecular biology of the cell

authors： Raspelli E,Cassani C,Lucchini G,Fraschini R

更新日期：2011-07-01 00:00:00

abstract：:Ubiquitin-mediated proteolysis plays a key role in many pathways inside the cell and is particularly important in regulating cell cycle transitions. SCF (Skp1/Cul1/F-box protein) complexes are modular ubiquitin ligases whose specificity is determined by a substrate-binding F-box protein. Dia2 is a Saccharomyces cerevi...

journal_title：Molecular biology of the cell

authors： Koepp DM,Kile AC,Swaminathan S,Rodriguez-Rivera V

更新日期：2006-04-01 00:00:00

abstract：:Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by growth deficiency, immunodeficiency, genomic instability, and the early development of cancers of many types. BLM, the protein encoded by BLM, the gene mutated in BS, is localized in nuclear foci and absent from BS cells. BLM encodes a DNA hel...

journal_title：Molecular biology of the cell

authors： Neff NF,Ellis NA,Ye TZ,Noonan J,Huang K,Sanz M,Proytcheva M

更新日期：1999-03-01 00:00:00

abstract：:Sorting nexin 1 (SNX1) and SNX2, homologues of the yeast vacuolar protein-sorting (Vps)5p, contain a phospholipid-binding motif termed the phox homology (PX) domain and a carboxyl terminal coiled-coil region. A role for SNX1 in trafficking of cell surface receptors from endosomes to lysosomes has been proposed; howeve...

journal_title：Molecular biology of the cell

authors： Gullapalli A,Garrett TA,Paing MM,Griffin CT,Yang Y,Trejo J

更新日期：2004-05-01 00:00:00

abstract：:The Drosophila melanogaster genes Hrb87F and Hrb98DE encode the fly proteins HRB87F and HRB98DE (also known as hrp36 and hrp38, respectively) that are most similar in sequence and function to mammalian A/B-type hnRNP proteins. Using overexpression and deletion mutants of Hrb87F, we have tested the hypothesis that the ...

journal_title：Molecular biology of the cell

authors： Zu K,Sikes ML,Haynes SR,Beyer AL

更新日期：1996-07-01 00:00:00

abstract：:CLA4, encoding a protein kinase of the PAK type, and CDC11, encoding a septin, were isolated in a screen for synthetic lethality with CHS3, which encodes the chitin synthase III catalytic moiety. Although Ste20p shares some essential function with Cla4p, it did not show synthetic lethality with Chs3p. cla4 and cdc11 m...

journal_title：Molecular biology of the cell

authors： Schmidt M,Varma A,Drgon T,Bowers B,Cabib E

更新日期：2003-05-01 00:00:00

abstract：:Epithelial tissues are protective barriers that display a remarkable ability to repair wounds. Wound repair is often associated with an accumulation of actin and nonmuscle myosin II around the wound, forming a purse string. The role of actomyosin networks in generating mechanical force during wound repair is not well ...

journal_title：Molecular biology of the cell

authors： Fernandez-Gonzalez R,Zallen JA

更新日期：2013-10-01 00:00:00

abstract：:Vascular endothelial cells are important in a variety of physiological and pathophysiological processes. The growth and functions of vascular endothelial cells are regulated both by soluble mitogenic and differentiation factors and by interactions with the extracellular matrix; however, relatively little is known abou...

journal_title：Molecular biology of the cell

authors： Short SM,Talbott GA,Juliano RL

更新日期：1998-08-01 00:00:00

abstract：:In mammals, repression of translation during stress is associated with the assembly of stress granules in the cytoplasm, which contain a fraction of arrested mRNA and have been proposed to play a role in their storage. Because physical contacts are seen with GW bodies, which contain the mRNA degradation machinery, str...

journal_title：Molecular biology of the cell

authors： Mollet S,Cougot N,Wilczynska A,Dautry F,Kress M,Bertrand E,Weil D

更新日期：2008-10-01 00:00:00

abstract：:Astrocytes in neuron-free cultures typically lack processes, although they are highly process-bearing in vivo. We show that basic fibroblast growth factor (bFGF) induces cultured astrocytes to grow processes and that Ras family GTPases mediate these morphological changes. Activated alleles of rac1 and rhoA blocked and...

journal_title：Molecular biology of the cell

authors： Kalman D,Gomperts SN,Hardy S,Kitamura M,Bishop JM

更新日期：1999-05-01 00:00:00

abstract：:Notch and neurotrophins control neuronal shape, but it is not known whether their signaling pathways intersect. Here we report results from hippocampal neuronal cultures that are in support of this possibility. We found that low cell density or blockade of Notch signaling by a soluble Delta-Fc ligand decreased the mRN...

journal_title：Molecular biology of the cell

authors： Salama-Cohen P,Arévalo MA,Meier J,Grantyn R,Rodríguez-Tébar A

更新日期：2005-01-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1) protects cells from oxidative stress via the base excision repair pathway and as a redox transcriptional coactivator. It is required for tumor progression/metastasis, and its up-regulation is associated with cancer resistance. Loss of APE1 expression causes ce...

journal_title：Molecular biology of the cell

authors： Vascotto C,Bisetto E,Li M,Zeef LA,D'Ambrosio C,Domenis R,Comelli M,Delneri D,Scaloni A,Altieri F,Mavelli I,Quadrifoglio F,Kelley MR,Tell G

更新日期：2011-10-01 00:00:00

abstract：:Drosophila myosin IB (Myo1B) is one of two class I myosins in the Drosophila genome. In the larval and adult midgut enterocyte, Myo1B is present within the microvillus (MV) of the apical brush border (BB) where it forms lateral tethers between the MV membrane and underlying actin filament core. Expression of green flu...

journal_title：Molecular biology of the cell

authors： Hegan PS,Mermall V,Tilney LG,Mooseker MS

更新日期：2007-11-01 00:00:00

abstract：:Both sporadic and familial Alzheimer's disease (AD) patients exhibit increased chromosome aneuploidy, particularly trisomy 21, in neurons and other cells. Significantly, trisomy 21/Down syndrome patients develop early onset AD pathology. We investigated the mechanism underlying mosaic chromosome aneuploidy in AD and r...

journal_title：Molecular biology of the cell

authors： Granic A,Padmanabhan J,Norden M,Potter H

更新日期：2010-02-15 00:00:00

abstract：:Epidermolysis bullosa simplex associated with late-onset muscular dystrophy (EBS-MD) is an autosomal recessive disorder resulting from mutations in the plectin gene. The majority of these mutations occur within the large exon 31 encoding the central rod domain and leave the production of a low-level rodless plectin sp...

journal_title：Molecular biology of the cell

authors： Ketema M,Secades P,Kreft M,Nahidiazar L,Janssen H,Jalink K,de Pereda JM,Sonnenberg A

更新日期：2015-07-01 00:00:00

abstract：:Previous research has found that a gamma-tubulin mutation in Schizosaccharomyces pombe is synthetically lethal with a deletion of the C-terminal motor domain kinesin-like protein gene pkl1, but the lethality of the double mutant prevents a phenotypic analysis of the synthetic interaction. We have investigated interact...

journal_title：Molecular biology of the cell

authors： Prigozhina NL,Walker RA,Oakley CE,Oakley BR

更新日期：2001-10-01 00:00:00

abstract：:Recent evidence has shown that members of the Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit. The different members of the IL-6 cytokine subfamily induce distinct patterns of Jak-Tyk phosphorylation in differ...

journal_title：Molecular biology of the cell

authors： Wang Y,Fuller GM

更新日期：1994-07-01 00:00:00

abstract：:The intestinal cells of Caenorhabditis elegans embryos contain prominent, birefringent gut granules that we show are lysosome-related organelles. Gut granules are labeled by lysosomal markers, and their formation is disrupted in embryos depleted of AP-3 subunits, VPS-16, and VPS-41. We define a class of gut granule lo...

journal_title：Molecular biology of the cell

authors： Hermann GJ,Schroeder LK,Hieb CA,Kershner AM,Rabbitts BM,Fonarev P,Grant BD,Priess JR

更新日期：2005-07-01 00:00:00

abstract：:Defining how organisms respond to environmental change has always been an important step toward understanding their adaptive capacity and physiology. Variation in transcription during stress has been widely described in model species, especially in the yeast Saccharomyces cerevisiae, which helped to shape general rule...

journal_title：Molecular biology of the cell

authors： Brion C,Pflieger D,Souali-Crespo S,Friedrich A,Schacherer J

更新日期：2016-05-15 00:00:00

abstract：:S100A4, a member of the S100 family of Ca(2+)-binding proteins, is directly involved in tumor metastasis. In addition to its expression in tumor cells, S100A4 is expressed in normal cells and tissues, including fibroblasts and cells of the immune system. To examine the contribution of S100A4 to normal physiology, we e...

journal_title：Molecular biology of the cell

authors： Li ZH,Dulyaninova NG,House RP,Almo SC,Bresnick AR

更新日期：2010-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae genes TOR1 and TOR2 were originally identified by mutations that confer resistance to the immunosuppressant rapamycin. TOR2 was previously shown to encode an essential 282-kDa phosphatidylinositol kinase (PI kinase) homologue. The TOR1 gene product is also a large (281 kDa) PI kinase homol...

journal_title：Molecular biology of the cell

authors： Helliwell SB,Wagner P,Kunz J,Deuter-Reinhard M,Henriquez R,Hall MN

更新日期：1994-01-01 00:00:00

abstract：:The development and progression of cardiac hypertrophy often leads to heart failure and death, and important modulators of hypertrophy include the histone deacetylase proteins (HDACs). Estrogen inhibits cardiac hypertrophy and progression in animal models and humans. We therefore investigated the influence of 17-β-est...

journal_title：Molecular biology of the cell

authors： Pedram A,Razandi M,Narayanan R,Dalton JT,McKinsey TA,Levin ER

更新日期：2013-12-01 00:00:00

abstract：:Ion transport in various tissues can be regulated by the cortical actin cytoskeleton. Specifically, involvement of actin dynamics in the regulation of nonvoltage-gated sodium channels has been shown. Herein, inside-out patch clamp experiments were performed to study the effect of the heterodimeric actin capping protei...

journal_title：Molecular biology of the cell

authors： Shumilina EV,Negulyaev YA,Morachevskaya EA,Hinssen H,Khaitlina SY

更新日期：2003-04-01 00:00:00