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Targeted therapies as adjuvant treatment for early-stage colorectal cancer: first impressions and clinical questions.

Abstract：

:The use of adjuvant chemotherapy has improved survival in early-stage colon cancer. Ongoing adjuvant clinical trials are evaluating the addition of targeted therapies to standard chemotherapy regimen. Preliminary results with bevacizumab were disappointing. Also, cetuximab added to chemotherapy does not seem to be better than chemotherapy alone, even in selected wild-type KRAS populations. A better understanding of mechanisms of action of drugs, tumor biology, and predictive biomarkers are needed to design future adjuvant trials.

journal_name

Clin Colorectal Cancer

journal_title

Clinical colorectal cancer

authors

Chibaudel B,Tournigand C,André T,Larsen AK,de Gramont A

doi

10.3816/CCC.2010.n.039

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

269-73

issue

5

eissn

1533-0028

issn

1938-0674

pii

3542217055600804

journal_volume

9

pub_type

杂志文章

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