Abstract：
BACKGROUND:Recent trends have identified increasing number of young individuals with rectal and colon cancers. These individuals, who are younger than 50 years old, in most instances would not meet screening guidelines. We aimed to report the characteristics and trend of the rising proportion of young individuals being diagnosed with rectal and colon cancers at our institutions. PATIENTS AND METHODS:This study included 3381 rectal and colon cancer patients from the Mayo Clinic cancer registry from 1972 to 2017 who were diagnosed with rectal or colon cancer and who were < 50 years old. Patient and cancer characteristics are described. The Cochran-Armitage trend test was used to see if the change in percentage diagnosed at age < 50 years had a significant trend over the years. A linear regression model was fit to estimate the percentage change per year when the trend was approximately linear. RESULTS:The percentage of patients diagnosed with rectal or colon cancer in different age categories over the years showed a rising trend for individuals aged < 50. Most of these tumors were distal (rectum, left-sided colon, and right-sided colon were 49.8%, 28.8%, and 21.4%, respectively). This was more so for patients < 50 diagnosed with rectal cancer, which showed a linear increase at a rate of 0.26% per year (P < .001). CONCLUSION:Our study affirms the rising proportion of colorectal cancers found in young individuals, with a linear ongoing rise of rectal cancers in particular. This may have implications for the current screening recommendations for colorectal cancers, which are already being revised.
journal_name
Clin Colorectal Cancerjournal_title
Clinical colorectal cancerauthors
Kasi PM,Shahjehan F,Cochuyt JJ,Li Z,Colibaseanu DT,Merchea Adoi
10.1016/j.clcc.2018.10.002subject
Has Abstractpub_date
2019-03-01 00:00:00pages
e87-e95issue
1eissn
1533-0028issn
1938-0674pii
S1533-0028(18)30406-7journal_volume
18pub_type
杂志文章abstract：BACKGROUND:Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Their real-life evaluation is insufficient, especially in elderly and frail patients. The aim was to describe use, safety, and effectiveness of targeted therapies in first-line mCRC treatment according to age. PATIENTS AND...
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
doi：10.3816/CCC.2003.n.010
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
doi：10.3816/CCC.2008.n.015
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
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journal_title：Clinical colorectal cancer
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
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journal_title：Clinical colorectal cancer
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.clcc.2011.03.004
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章
doi：10.1016/j.clcc.2019.09.002
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pub_type： 杂志文章,评审
doi：10.1016/j.clcc.2016.06.006
更新日期：2017-03-01 00:00:00
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journal_title：Clinical colorectal cancer
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doi：10.1016/j.clcc.2017.10.002
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
doi：10.3816/CCC.2008.n.050
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journal_title：Clinical colorectal cancer
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doi：10.3816/CCC.2008.n.010
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pub_type： 杂志文章,随机对照试验
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journal_title：Clinical colorectal cancer
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pub_type： 杂志文章,评审
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章
doi：10.1016/j.clcc.2018.03.006
更新日期：2018-09-01 00:00:00
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章
doi：10.1016/j.clcc.2018.08.002
更新日期：2018-12-01 00:00:00
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journal_title：Clinical colorectal cancer
pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
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journal_title：Clinical colorectal cancer
pub_type： 临床试验,杂志文章
doi：10.1016/j.clcc.2012.07.004
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Patients with metastatic colorectal cancer (CRC) may present with oligometastatic lung lesions for which stereotactic ablative radiotherapy (SABR) can be utilized. This study aims to report efficacy and prognostic factors associated with colorectal lung metastases treated with SABR. MATERIAL AND METHODS:T...
journal_title：Clinical colorectal cancer
pub_type： 杂志文章
doi：10.1016/j.clcc.2016.08.003
更新日期：2017-09-01 00:00:00
