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Targeted therapy in colorectal cancer.

Abstract：

:Adjuvant therapy can reduce the risk of disease recurrence in patients with stage II-IV colorectal cancer. Recently, 3 monoclonal antibodies have been shown to improve clinical outcome in this group of patients. Bevacizumab is an antiangiogenesis agent that has been shown in clinical and preclinical models to reverse the effects of proangiogenic molecules. Bevacizumab is active in the adjuvant setting and in the treatment of metastatic disease. Cetuximab is targeted to the epidermal growth factor receptor. Panitumumab is a fully human immunoglobulin G2 antibody that also binds to the epidermal growth factor receptor. Combination therapies of monoclonal therapies and chemotherapy have resulted in better clinical outcomes than with either modality alone.

journal_name

Clin Colorectal Cancer

journal_title

Clinical colorectal cancer

authors

Wadler S

doi

10.3816/CCC.2007.n.004

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

357-61

issue

5

eissn

1533-0028

issn

1938-0674

pii

S1533-0028(11)70263-8

journal_volume

6

pub_type

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