The potential of multiple synovial-fluid protein-concentration analyses in the assessment of knee osteoarthritis.


CONTEXT:Joint trauma is a risk factor for osteoarthritis (OA), which is becoming an increasingly important orthopedic concern for athletes and nonathletes alike. For advances in OA prevention, diagnosis, and treatment to occur, a greater understanding of the biochemical environment of the affected joint is needed. OBJECTIVE:To demonstrate the potential of a biochemical technique to enhance our understanding of and diagnostic capabilities for osteoarthritis. DESIGN:Cross-sectional. SETTING:Outpatient orthopedic practice. PARTICIPANTS:8 subjects: 4 OA-knee participants (65 ± 6 y of age) and 4 normal-knee participants (54 ± 10 y) with no history of knee OA based on bilateral standing radiographs. INTERVENTION:The independent variable was group (OA knee, normal knee). MAIN OUTCOME MEASURES:16 knee synovial-protein concentrations categorized as follows: 4 as pro-inflammatory, or catabolic, cytokines; 5 as anti-inflammatory, or protective, cytokines; 3 as catabolic enzymes; 2 as tissue inhibitors of metalloproteinases [TIMPs]; and 2 as adipokines. RESULTS:Two anti-inflammatory cytokines (interleukin [IL]-13 and osteoprotegerin) and a pro-inflammatory cytokine (IL-1β) were significantly lower in the OA knees. Two catabolic enzymes (matrix metalloproteinase [MMP]-2 and MMP-3) were significantly elevated in OA knees. TIMP-2, an inhibitor of MMPs, was significantly elevated in OA knees. CONCLUSIONS:Six of the 16 synovial-fluid proteins were significantly different between OA knees and normal knees in this study. Future research using a similar multiplex ELISA approach or other proteomic techniques may enable researchers and clinicians to develop more accurate biochemical profiles of synovial fluid to help diagnose OA, identify subsets of OA or individual characteristics, guide clinical decisions, and identify patients at risk for OA after knee injury.


J Sport Rehabil


Driban JB,Balasubramanian E,Amin M,Sitler MR,Ziskin MC,Barbe MF




Has Abstract


2010-11-01 00:00:00












  • The Effects of Doming of the Diaphragm in Subjects With Short-Hamstring Syndrome: A Randomized Controlled Trial.

    abstract:CONTEXT:Taking into account the complex structure of the diaphragm and its important role in the postural chain, the authors were prompted to check the effects of a diaphragm technique on hamstring flexibility. OBJECTIVE:To evaluate the effects of the doming-of-the-diaphragm (DD) technique on hamstrings flexibility an...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章,随机对照试验


    authors: Valenza MC,Cabrera-Martos I,Torres-Sánchez I,Garcés-García A,Mateos-Toset S,Valenza-Demet G

    更新日期:2015-11-01 00:00:00

  • Comparison of Regional Hamstrings Activation During Resistance Exercises in Females With Prior Athletic Experience.

    abstract:CONTEXT:Within each hamstring muscle, there are segments with separate nerve innervation. However, a better understanding of activation levels within these regions during resistance exercise could lead to region-specific training for improved performance and injury prevention. OBJECTIVE:To compare muscle activation le...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: McCurdy K,Walker J

    更新日期:2019-09-24 00:00:00

  • Paraspinal muscle activity during symmetrical and asymmetrical weight training in idiopathic scoliosis.

    abstract:CONTEXT:Various studies report decreased muscle activation in the concavity of the curve in patients with scoliosis. Such decreased muscle-performance capacity could lead to sustained postural deficits. OBJECTIVE:To investigate whether specific asymmetrical sports therapy exercises rather than symmetrical back strengt...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Schmid AB,Dyer L,Böni T,Held U,Brunner F

    更新日期:2010-08-01 00:00:00

  • Relationship Between Seated Single-Arm Shot Put and Isokinetic Shoulder Flexion and Elbow Extension Strength.

    abstract:CONTEXT:A recent report demonstrated moderate to strong relationships between seated single-arm shot-put (SSASP) test performance and isokinetic pushing forces at varying velocities, directly supporting the SSASP test as a reflection of multijoint upper-extremity strength. Yet, no previous work appears to have assessed...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Watson MD,Davies GJ,Riemann BL

    更新日期:2020-09-01 00:00:00

  • Self-Myofascial Release of the Superficial Back Line Improves Sit-and-Reach Distance.

    abstract:CONTEXT:Decreased hamstring flexibility can lead to a plethora of musculoskeletal injuries, including low back pain, hamstring strains, and patellofemoral pain. Lack of flexibility may be the result of myofascial adhesions. The fascia connected to the hamstrings is part of the superficial back line that runs from the c...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Williams W,Selkow NM

    更新日期:2019-10-18 00:00:00

  • Can the Use of Unstable Surfaces and Instruction for Conscious Abdominal Contraction Increase the EMG Activity of the Periscapular Muscles During the Dynamic Push-Up?

    abstract:CONTEXT:It is believed that conscious abdominal contraction (CAC) during exercise encourages greater periscapular activation through existing myofascial connections. On the other hand, it is postulated that the use of unstable surfaces would promote greater neuromuscular demand. OBJECTIVE:To analyze the effect of CAC ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: de Araújo RC,Nascimento VYS,Torres RJB,Trombini-Souza F,Behm D,Pitangui ACR

    更新日期:2020-02-01 00:00:00

  • Body-Cooling Paradigm in Sport: Maximizing Safety and Performance During Competition.

    abstract:CONTEXT:Although body cooling has both performance and safety benefits, knowledge on optimizing cooling during specific sport competition is limited. OBJECTIVES:To identify when, during sport competition, it is optimal for body cooling and to identify optimal body-cooling modalities to enhance safety and maximize spor...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章,评审


    authors: Adams WM,Hosokawa Y,Casa DJ

    更新日期:2016-12-01 00:00:00

  • Effectiveness of Salted Ice Bag Versus Cryocompression on Decreasing Intramuscular and Skin Temperature.

    abstract:CONTEXT:Rest, ice, compression, and elevation are commonly recommended immediately after injury. Traditionally, ice bag (IB) with elastic wrap compression has been utilized; however, recently intermittent cryocompression units are being used. Limited research has evaluated tissue temperature decreases with intermittent...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Ostrowski J,Purchio A,Beck M,Leisinger J

    更新日期:2019-02-01 00:00:00

  • Dynamic-position-sense impairment's independence of perceived knee function in women with ACL reconstruction.

    abstract:CONTEXT:There is conflicting evidence in the literature regarding whether women with anterior cruciate ligament reconstruction (ACLR) demonstrate impaired proprioception. This study examined dynamic-position-sense accuracy and central-nervous-system (CNS) processing time between those with and without long-term ACLR. ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Littmann AE,Iguchi M,Madhavan S,Kolarik JL,Shields RK

    更新日期:2012-02-01 00:00:00

  • Increased active hamstring stiffness after exercise in women with a history of low back pain.

    abstract:OBJECTIVE:To compare active hamstring stiffness in female subjects with and without a history of low back pain (LBP) after a standardized 20-min aerobic-exercise session. DESIGN:Case control. SETTING:Laboratory. PARTICIPANTS:12 women with a history of recurrent episodes of LBP (age = 22.4 ± 2.1 y, mass = 67.1 ± 11.8...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Bedard RJ,Kim KM,Grindstaff TL,Hart JM

    更新日期:2013-02-01 00:00:00

  • Infrared Thermography Protocol on Reducing the Incidence of Soccer Injuries.

    abstract:CONTEXT:Infrared thermography has been used to detect skeletal muscle overload and fatigue in athletes, but its use in injury prevention in professional soccer has not been studied to date. OBJECTIVES:To establish a novel injury prevention program based on infrared thermography and to determine its influence on the in...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Gómez-Carmona P,Fernández-Cuevas I,Sillero-Quintana M,Arnaiz-Lastras J,Navandar A

    更新日期:2020-11-01 00:00:00

  • Electromyographic Analysis of Hip and Trunk Muscle Activity During Side Bridge Exercises in Subjects With Gluteus Medius Weakness.

    abstract:CONTEXT:Side bridge exercises strengthen the hip, trunk, and abdominal muscles and challenge the trunk muscles without the high lumbar compression associated with trunk extension or curls. Previous research using electromyography (EMG) reports that performance of the side bridge exercise highly activates the gluteus me...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Lee KE,Baik SM,Yi CH,Kwon OY,Cynn HS

    更新日期:2021-12-30 00:00:00

  • The Relationship Between Hip Strength and the Y Balance Test.

    abstract:CONTEXT:The Y Balance Test was developed as a test of dynamic postural control and has been shown to be predictive of lower-extremity injury. However, the relationship between hip strength and performance on the Y Balance Test has not been fully elucidated. OBJECTIVE:The goal of this study was to identify the relation...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Wilson BR,Robertson KE,Burnham JM,Yonz MC,Ireland ML,Noehren B

    更新日期:2018-09-01 00:00:00

  • Platelet-Rich Plasma Compared With Other Common Injection Therapies in the Treatment of Chronic Lateral Epicondylitis.

    abstract:CLINICAL SCENARIO:Lateral epicondylitis (LE) is a relatively common pathology capable of producing chronic debilitation in a variety of patients. A newer treatment for orthopedic conditions is platelet-rich plasma (PrP) local injection. FOCUSED CLINICAL QUESTION:Is PrP a more appropriate injection therapy for LE than ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章,评审


    authors: Rodik T,McDermott B

    更新日期:2016-02-01 00:00:00

  • Comparison of Upper Trapezius and Infraspinatus Myofascial Trigger Point Therapy by Dry Needling in Overhead Athletes With Unilateral Shoulder Impingement Syndrome.

    abstract:CONTEXT:Chronic musculoskeletal disorders in the shoulder joint are often associated with myofascial trigger points (MTrPs), particularly in the upper trapezius (UT) muscle. Dry needling (DN) is a treatment of choice for myofascial pain syndrome. However, local lesions and severe postneedle soreness sometimes hamper th...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章,随机对照试验


    authors: Kamali F,Sinaei E,Morovati M

    更新日期:2019-03-01 00:00:00

  • Figure-8 Strap Application: Immediate Alteration of Pectoralis Minor Length and Scapular Alignment During Arm-Lifting Exercise in Participants With Forward Shoulder Posture.

    abstract:CONTEXT:Scapular bracing can correct scapular kinematics and restore normal scapular-muscle activity. However, there is little evidence to support the beneficial effects of a figure-8 strap, a type of scapular bracing, on muscle length, scapular alignment, and muscle activity during arm-lifting exercise. OBJECTIVE:To ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Ko CH,Cynn HS,Lee JH,Yoon TL,Choi SA

    更新日期:2016-08-01 00:00:00

  • Negative effects on postural control after anterior cruciate ligament reconstruction as measured by the balance error scoring system.

    abstract:CONTEXT:Anterior cruciate ligament (ACL) reconstruction is the standard of care for individuals with ACL rupture. Balance deficits have been observed in patients with ACL reconstruction (ACLR) using advanced posturography, which is the current gold standard. It is unclear if postural-control deficits exist when assesse...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Smith MD,Bell DR

    更新日期:2013-08-01 00:00:00

  • A randomized, controlled study of a rehabilitation model to improve knee-function self-efficacy with ACL injury.

    abstract:CONTEXT:The Knee Self-Efficacy Scale (K-SES) has good reliability, validity, and responsiveness for patients' perceived knee-function self-efficacy during rehabilitation after an anterior cruciate ligament (ACL) injury. Preoperative knee-function self-efficacy has also been shown to have a predictive ability in terms o...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章,随机对照试验


    authors: Thomeé P,Währborg P,Börjesson M,Thomeé R,Eriksson BI,Karlsson J

    更新日期:2010-05-01 00:00:00

  • The Effectiveness of Low-Dye Taping in Reducing Pain Associated With Plantar Fasciitis.

    abstract::Plantar fasciitis is one of the most common musculoskeletal disorders of the foot. Initial treatment of plantar fasciitis is typically conservative and may include heel padding, steroid injections, night splinting, calf stretching, ultrasound, foot orthoses, and taping. However, while custom foot orthoses are a common...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Verbruggen LA,Thompson MM,Durall CJ

    更新日期:2018-01-01 00:00:00

  • Quadratic Association Between Corticomotor and Spinal-Reflexive Excitability and Self-Reported Disability in Participants With Chronic Ankle Instability.

    abstract:CONTEXT:Spinal-reflexive and corticomotor excitability may have a critical role in altering muscle function needed to stabilize the ankle in people with chronic ankle instability (CAI). OBJECTIVE:To determine the association between self-reported disability and both spinal-reflexive and corticomotor excitability in pe...

    journal_title:Journal of sport rehabilitation

    pub_type: 临床试验,杂志文章


    authors: Harkey M,McLeod MM,Terada M,Gribble PA,Pietrosimone BG

    更新日期:2016-05-01 00:00:00

  • The effect of gender on foot anthropometrics in older people.

    abstract:CONTEXT:Some questions remain regarding the anthropometric differences between the feet of young men and women, but the gap is much greater when dealing with older adults. No studies were found concerning these differences in an exclusively older adult population, which makes it difficult to manufacture shoes based on ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Paiva de Castro A,Rebelatto JR,Aurichio TR

    更新日期:2011-08-01 00:00:00

  • Effect of Humeral-Elevation Angle on Electromyographic Activity in the Serratus Anterior During the Push-Up-Plus Exercise.

    abstract:CONTEXT:The push-up-plus (PP) exercise has been recommended for strengthening of the serratus anterior (SA). Previous studies have investigated the effect of different stability properties of the base of support to adjust the difficulty level of SA muscle-strengthening exercises in the PP position. However, the optimal...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Hwang UJ,Kwon OY,Jeon IC,Kim SH,Weon JH

    更新日期:2017-01-01 00:00:00

  • Immediate Effects of a Single Spinal Manipulation on Lower-Limb Strength in Healthy Individuals: A Critically Appraised Topic.

    abstract::Clinical Scenario: Many people with lower quarter musculoskeletal dysfunction present with muscle weakness. Strength training hypertrophies muscle and increases strength, but often requires periods over 6 weeks, which can exceed the episode of care. Weakness can persist despite muscle hypertrophy, particularly in the ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Wong CK,Conway L,Fleming G,Gopie C,Liebeskind D,Xue S

    更新日期:2020-06-05 00:00:00

  • Relationships between knee valgus, hip-muscle strength, and hip-muscle recruitment during a single-limb step-down.

    abstract:CONTEXT:Reduced strength and activation of hip muscles might correlate with increased weight-bearing knee valgus. OBJECTIVE:To describe relationships among frontal-plane hip and knee angles, hip-muscle strength, and electromyographic (EMG) recruitment in women during a step-down. DESIGN:Exploratory study. SETTING:La...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Hollman JH,Ginos BE,Kozuchowski J,Vaughn AS,Krause DA,Youdas JW

    更新日期:2009-02-01 00:00:00

  • Physiological responses, rating of perceived exertion, and stride characteristics during walking on dry land and walking in water, both with and without a water current.

    abstract:CONTEXT:Walking in water has been included in rehabilitation programs. However, there is a dearth of information regarding the influence of a water current on physiological responses, rating of perceived exertion (RPE), and stride characteristics of subjects while they walk in water. OBJECTIVE:To compare physiological...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Masumoto K,Hamada A,Tomonaga HO,Kodama K,Hotta N

    更新日期:2012-05-01 00:00:00

  • Adductor longus activation during common hip exercises.

    abstract:CONTEXT:Hip-adductor strains are among the most common lower-extremity injuries sustained in athletics. Treatment of these injuries involves a variety of exercises used to target the hip adductors. OBJECTIVE:To identify the varying activation levels of the adductor longus during common hip-adductor exercises. DESIGN:...

    journal_title:Journal of sport rehabilitation

    pub_type: 临床试验,杂志文章


    authors: Delmore RJ,Laudner KG,Torry MR

    更新日期:2014-05-01 00:00:00

  • Is State Anxiety, Trait Anxiety, or Anxiety Sensitivity a Clinical Predictor of Symptoms in Those Presenting With Mild Traumatic Brain Injury or Concussion?

    abstract::Clinical Scenario: Mild traumatic brain injury, or concussion, has been associated with physical, cognitive, and emotional sequelae. Little is understood in regard to many characteristics, such as anxiety, and their effect on post-concussion symptoms. CLINICAL QUESTION:Is state anxiety, trait anxiety, or anxiety sens...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Hixson KM,Allen AN,Williams AS,McLeod TCV

    更新日期:2017-11-01 00:00:00

  • The relationship of periscapular strength on scapular upward rotation in professional baseball pitchers.

    abstract:CONTEXT:Deficiencies in scapular upward rotation and periscapular strength have been associated with various shoulder pathologies and decreased athletic performance. Therefore, proper periscapular strength and concomitant scapular upward rotation are important factors among overhead athletes, such as baseball players. ...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Laudner KG,Stanek JM,Meister K

    更新日期:2008-05-01 00:00:00

  • Evaluating patellar kinematics through magnetic resonance imaging during open- and closed-kinetic-chain exercises.

    abstract:PURPOSE:To evaluate patellar kinematics of volunteers without knee pain at rest and during isometric contraction in open-and closed-kinetic-chain exercises. METHODS:Twenty individuals took part in this study. All were submitted to magnetic resonance imaging (MRI) during rest and voluntary isometric contraction (VIC) i...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章


    authors: Felicio LR,Saad MC,Liporaci RF,Baffa Ado P,Dos Santos AC,Bevilaqua-Grossi D

    更新日期:2010-02-01 00:00:00

  • Effects of Static and Dynamic Stretching on Injury Prevention in High School Soccer Athletes: A Randomized Trial.

    abstract:OBJECTIVE:To determine if there is any benefit to static stretching after performing a dynamic warm-up in the prevention of injury in high school soccer athletes. DESIGN:Prospective cluster randomized nonblinded study. SETTING:12 high schools with varsity and junior varsity boys' soccer teams (24 soccer teams) across...

    journal_title:Journal of sport rehabilitation

    pub_type: 杂志文章,随机对照试验


    authors: Zakaria AA,Kiningham RB,Sen A

    更新日期:2015-08-01 00:00:00