Abstract:
:Parkinson's disease (PD) is a common, heterogeneous syndrome diagnosed clinically by the presence of classical neurological symptoms and the absence of 'red flags' that suggest alternative secondary parkinsonian disorders. Neuropathologically, nigrostriatal loss and the presence of proteinaceous inclusions (Lewy bodies) confirm the diagnosis. For PD, molecular profiling promises much but is yet to deliver in terms of breakthroughs for identifying at-risk individuals, detecting disease at early stages, improving diagnostic certainty, prognosticating future outcomes or providing surrogate markers of therapeutic efficacy. Recent, large-scale omics studies, driven by technological advances, have generated terabytes of data but not yet met the goal of developing biomarkers suitable for clinical use in PD. In this article we critically evaluate the recent literature to identify the key roadblocks and realistic opportunities facing researchers interested in utilizing molecular profiling in the clinic to improve the diagnosis and treatment of PD.
journal_name
Expert Rev Mol Diagnjournal_title
Expert review of molecular diagnosticsauthors
Mellick GD,Silburn PA,Sutherland GT,Siebert GAdoi
10.1586/erm.10.86subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1035-50issue
8eissn
1473-7159issn
1744-8352journal_volume
10pub_type
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
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pub_type: 社论
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更新日期:2005-09-01 00:00:00
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doi:10.1586/erm.09.25
更新日期:2009-07-01 00:00:00
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Expert review of molecular diagnostics
pub_type: 杂志文章,评审
doi:10.1586/14737159.4.4.527
更新日期:2004-07-01 00:00:00
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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