Abstract:
:A quantitative dosimetric comparison was performed between Monte Carlo (MC) simulations and analytic calculations at the (sub) cellular level (V79 cells) for four nucleus-incorporated radiochemicals ((125)I/(123)I/(77)Br-UdR and A (125)IP) and two radiochemicals that localised mainly in the cytoplasm of cells ((125)I-dihydrorhodamine and Na(2)(51)CrO(4)). A microscopic investigation around the decay site of the three DNA-incorporated radionuclides ((125)I/(123)I/(77)Br-UdR) was also carried out. On the whole, deviations between MC and analytic calculations for the absorbed dose and dose rate to the cell nucleus were within ∼10%. The dose rate to the nucleus for the radiochemicals that mainly localised in the cytoplasm was greater than that for the nucleus-incorporated ones. Also evident was that the dose rate to the nucleus was approximately the same for the three DNA-incorporated radiochemicals. In contrast to the small differences found between MC and analytic calculations for the (average) absorbed dose to the nucleus, the dosimetric analysis at the microscopic level for the three DNA-incorporated radionuclides showed that the two computational approaches lead to a completely different energy deposition pattern around the decay site.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Bousis Cdoi
10.1093/rpd/ncq293subject
Has Abstractpub_date
2011-01-01 00:00:00pages
33-41issue
1eissn
0144-8420issn
1742-3406pii
ncq293journal_volume
143pub_type
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