Dosimetry on sub-cellular level for intracellular incorporated auger-electron-emitting radionuclides: a comparison of Monte Carlo simulations and analytic calculations.

Abstract:

:A quantitative dosimetric comparison was performed between Monte Carlo (MC) simulations and analytic calculations at the (sub) cellular level (V79 cells) for four nucleus-incorporated radiochemicals ((125)I/(123)I/(77)Br-UdR and A (125)IP) and two radiochemicals that localised mainly in the cytoplasm of cells ((125)I-dihydrorhodamine and Na(2)(51)CrO(4)). A microscopic investigation around the decay site of the three DNA-incorporated radionuclides ((125)I/(123)I/(77)Br-UdR) was also carried out. On the whole, deviations between MC and analytic calculations for the absorbed dose and dose rate to the cell nucleus were within ∼10%. The dose rate to the nucleus for the radiochemicals that mainly localised in the cytoplasm was greater than that for the nucleus-incorporated ones. Also evident was that the dose rate to the nucleus was approximately the same for the three DNA-incorporated radiochemicals. In contrast to the small differences found between MC and analytic calculations for the (average) absorbed dose to the nucleus, the dosimetric analysis at the microscopic level for the three DNA-incorporated radionuclides showed that the two computational approaches lead to a completely different energy deposition pattern around the decay site.

journal_name

Radiat Prot Dosimetry

authors

Bousis C

doi

10.1093/rpd/ncq293

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

33-41

issue

1

eissn

0144-8420

issn

1742-3406

pii

ncq293

journal_volume

143

pub_type

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