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Acute fatty liver of pregnancy in a Taiwanese tertiary care center: a retrospective review.

Abstract：

OBJECTIVE:To evaluate the demographics, clinical presentations, laboratory findings, and maternal and fetal outcomes in patients with acute fatty liver of pregnancy. MATERIALS AND METHODS:A retrospective review was conducted of the records of pregnant patients with a diagnosis of acute fatty liver in a tertiary medical center over a 22-year period. RESULTS:Eighteen patients with acute fatty liver of pregnancy were recruited, all of whom developed the disease in the third trimester. Eleven women (61%) were primigravid and four (22%) had twin pregnancies; six (33%) were diagnosed antepartum, and the other 12 (67%) were diagnosed postpartum. There were two maternal deaths (11%) and four fetal deaths (18%). The most common complications apart from severe liver dysfunction were acute renal failure (83%), hypoglycemia (61%), and disseminated intravascular coagulation (61%). CONCLUSION:Women who become acutely ill during the third trimester of pregnancy should undergo tests for acute fatty liver of pregnancy, including laboratory tests for assessing liver function and coagulation profile.

journal_name

Taiwan J Obstet Gynecol

journal_title

Taiwanese journal of obstetrics & gynecology

authors

Lau HH,Chen YY,Huang JP,Chen CY,Su TH,Chen CP

doi

10.1016/S1028-4559(10)60033-2

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

156-9

issue

2

eissn

1028-4559

issn

1875-6263

pii

S1028-4559(10)60033-2

journal_volume

49

pub_type

杂志文章

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