Cranioplasty, vertebral body replacement, and spinal fusion with tobramycin-impregnated methylmethacrylate.

Abstract:

:A prospective analysis of cranioplasty, vertebral body replacement, and spinal fusion using tobramycin-impregnated methylmethacrylate in 65 patients is presented. Cranioplastic methacrylate (1 packet) was mixed with 1.2 g of powdered tobramycin and placed into the desired location. The polymer was irrigated with bacitracin until it became solid. All patients received prophylactic medication with intravenously administered nafcillin and cephalosporin perioperatively and for 48 hours postoperatively. The follow-up time ranged from 7 to 57 months (mean, 32.2 months). Serum tobramycin levels remained below 0.5 microgram/ml in all patients tested, regardless of the time interval. Blood urea nitrogen and creatinine levels remained within normal limits in all patients, and there has been no nephrotoxicity or ototoxicity. There has been 1 infection among the 65 patients (1%) to date. It occurred in a patient who had a previously treated local infection. Cranioplasty, vertebral body replacement, or spinal fusion with tobramycin-impregnated methylmethacrylate is safe and may reduce the incidence of infection.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Shapiro SA

doi

10.1097/00006123-199106000-00001

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

789-91

issue

6

eissn

0148-396X

issn

1524-4040

journal_volume

28

pub_type

杂志文章
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