Abstract:
OBJECTIVE:The diagnosis of isolated central nervous system angiitis often requires both cerebral angiography and biopsy for diagnosis. CLINICAL PRESENTATION:We present a case of gliomatosis cerebri with demonstrated angiographic changes suggestive of a central nervous system vasculitis. INTERVENTION:A 47-year-old woman presented with a 2-week history of worsening headache and progressive drowsiness. Magnetic resonance imaging scans revealed confluent nonenhancing T2-weighted hyperintensity involving the frontal white matter bilaterally, hypothalamus, and both thalami. A four-vessel angiogram revealed diffuse arterial beading with stenoses of a right frontal middle cerebral artery branch and the distal posterior cerebral artery and anterior cerebral artery branches, bilaterally. The biopsy revealed a Grade 2 fibrillary astrocytoma consistent with gliomatosis cerebri. CONCLUSION:Gliomatosis cerebri can mimic central nervous system vasculitis angiographically. Perivascular infiltration by tumor cells may be responsible for these changes.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Maramattom BV,Giannini C,Manno EM,Wijdicks EF,Campeau NGdoi
10.1227/01.NEU.0000216258.35308.AAsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
E1209; discussion E1209issue
6eissn
0148-396Xissn
1524-4040pii
00006123-200606000-00022journal_volume
58pub_type
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