Abstract:
BACKGROUND:Benign biliary strictures are typically managed endoscopically whereby an increasing size or number of plastic stents is placed at ERCP. Stents are often changed every 3 to 4 months based on the known median patency of a single biliary stent, but patency data for multiple biliary stents are lacking. OBJECTIVE:To assess the incidence of occlusion-free survival of multiple plastic biliary stents and the rate of premature occlusion if left in longer than 6 months. DESIGN:Retrospective. SETTING:Tertiary-care medical center (Charleston, SC). PATIENTS:Consecutive patients who received multiple plastic stents for benign nonhilar biliary strictures from 1994 to 2008 were identified. INTERVENTIONS:Exchange of multiple plastic biliary stents within 6 months (group 1) or 6 months or longer (group 2) after placement. MAIN OUTCOME MEASUREMENTS:Symptomatic stent occlusion. RESULTS:Seventy-nine patients with nonhilar extrahepatic benign biliary stricture underwent 125 ERCPs with multiple plastic biliary stents. Stents were scheduled for removal/exchange within 6 months in 52 patients (86 ERCPs) compared with after 6 months in 22 patients (26 ERCPs). The median interval between multiple stent placement and removal/exchange was 90 days for group 1 and 242 days for group 2. Premature stent occlusion occurred in 4 of 52 (7.7%) patients in group 1 versus 1 of 22 (4.5%) in group 2, with significantly longer occlusion-free survival in group 2 (log-rank P < .0001). LIMITATIONS:Retrospective study at a single tertiary referral center. CONCLUSION:Multiple plastic biliary stents for benign nonhilar strictures were associated with a low rate of premature symptomatic stent occlusion at more than 6 months and a longer occlusion-free survival.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Lawrence C,Romagnuolo J,Payne KM,Hawes RH,Cotton PBdoi
10.1016/j.gie.2010.05.029subject
Has Abstractpub_date
2010-09-01 00:00:00pages
558-63issue
3eissn
0016-5107issn
1097-6779pii
S0016-5107(10)01728-1journal_volume
72pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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