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Early cholecystectomy and ERCP are associated with reduced readmissions for acute biliary pancreatitis: a nationwide, population-based study.

Abstract：

BACKGROUND:Cholecystectomy is recommended during hospitalizations for acute biliary pancreatitis (ABP). OBJECTIVE:We sought to assess the population-based effectiveness of index cholecystectomy by using nationwide data. DESIGN:Retrospective, cohort study. SETTING:All acute-care hospitals in Canada from 2007 to 2010. PATIENTS:This study involved patients admitted for ABP in the Canadian Institutes for Health Information hospital discharge database. INTERVENTION:Cholecystectomy and therapeutic ERCP during the index admission. MAIN OUTCOME MEASUREMENTS:Rate of hospital readmissions for ABP. RESULTS:Among 5646 patients with ABP, 32% underwent cholecystectomy and 22% ERCP during the index admissions. Patients admitted to hospitals in the highest quartile for cholecystectomy volume were more than 10-fold likely to undergo cholecystectomy during the index admission (adjusted odds ratio 11.0; 95% confidence interval [CI], 7.4-16.5). The 12-month readmission rate for ABP was lower with cholecystectomy (5.6% vs 14.0%; P < .0001) and therapeutic ERCP (5.1% vs 13.1%; P < .0001). After multivariate adjustment, lower readmission rates were independently associated with both cholecystectomy (adjusted hazard ratio [HR] 0.39; 95% CI, 0.32-0.48) and ERCP (adjusted HR 0.37; 95% CI, 0.29-0.50). After excluding early readmissions (within 28 days of discharge), the adjusted HR for cholecystectomy was 0.43 (95% CI, 0.34-0.57). The admitting hospital's cholecystectomy volume was inversely associated with 12-month readmission rates for ABP (quartile 1, 15.9%; quartile 2, 13.9%; quartile 3, 11.3%; quartile 4, 10.0%; P < .001). LIMITATIONS:The study was based on hospital administrative data. CONCLUSION:Cholecystectomy and ERCP during the index admission were associated with reduced readmission rates for ABP, providing population-based evidence to support consensus guidelines that recommend early biliary intervention.

journal_name

Gastrointest Endosc

journal_title

Gastrointestinal endoscopy

authors

Nguyen GC,Rosenberg M,Chong RY,Chong CA

doi

10.1016/j.gie.2011.08.028

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

47-55

issue

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(11)02110-9

journal_volume

pub_type

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Early cholecystectomy and ERCP are associated with reduced readmissions for acute biliary pancreatitis: a nationwide, population-based study.