Abstract:
BACKGROUND:A gelatinous implant containing polymethylmethacrylate (PMMA) beads is successfully used to augment the diminished thickness of the chorium in patients with skin defects and wrinkles. The aim of the present study was to determine whether submucosal injection of PMMA microspheres into the lower esophageal folds decreases the severity of symptoms and acid reflux in patients with GERD. METHODS:Endoscopic submucosal implantation of PMMA was carried out in 10 patients with GERD who were either refractory to or dependent on proton pump inhibitors. Symptom severity score, 24-hour pH monitoring, upper GI endoscopy, and EUS were performed to evaluate the efficacy of implantation. RESULTS:A significant decrease in the symptom severity score and mean total time with esophageal pH less than 4 was noted after the implantation of PMMA (p < 0.05). Seven of 10 patients were taking no medication after PMMA implantation. There were no serious procedure-related complications. CONCLUSIONS:Endoscopic implantation of PMMA into the submucosa of the lower esophageal folds may be a new method for treating GERD. Further studies are required to determine the long-term efficacy of the procedure.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Feretis C,Benakis P,Dimopoulos C,Dailianas A,Filalithis P,Stamou KM,Manouras A,Apostolidis Ndoi
10.1067/mge.2001.113912keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
423-6issue
4eissn
0016-5107issn
1097-6779pii
S0016-5107(01)14275-6journal_volume
53pub_type
临床试验,杂志文章abstract:BACKGROUND:The endoscopic landmark used to diagnose Barrett's esophagus differs between Japanese and Western endoscopists. OBJECTIVE:To compare the degree of diagnostic variation in results achieved by Japanese endoscopists when using the palisade vessels as a landmark of the distal esophagus and when using the gastri...
journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章
doi:10.1016/j.gie.2006.04.029
更新日期:2006-08-01 00:00:00
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journal_title:Gastrointestinal endoscopy
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更新日期:1990-01-01 00:00:00
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journal_title:Gastrointestinal endoscopy
pub_type: 临床试验,杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Gastrointestinal endoscopy
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journal_title:Gastrointestinal endoscopy
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-08-01 00:00:00
abstract::Absolute alcohol is a potentially optimal agent for sclerotherapy of esophageal varices. It is cheap and readily available. We compared the efficacy and safety of alcohol with those of a commonly used sclerosing agent, polidocanol. The study was planned to include patients with previous bleeding from esophageal varice...
journal_title:Gastrointestinal endoscopy
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,meta分析,评审
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更新日期:1997-08-01 00:00:00
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-11-01 00:00:00
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章,随机对照试验
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更新日期:2007-05-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2011-08-01 00:00:00
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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journal_title:Gastrointestinal endoscopy
pub_type: 杂志文章
doi:
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