Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals.

abstract：:The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothelial cell BH4 is required for ...

journal_title：Thrombosis and haemostasis

authors： McNeill E,Channon KM

更新日期：2012-11-01 00:00:00

abstract：:Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 pati...

journal_title：Thrombosis and haemostasis

authors： Fiessinger JN,Aiach M,Capron L,Devanlay M,Vayssairat M,Juillet Y

更新日期：1981-06-30 00:00:00

abstract：:Previously, we demonstrated in a rat model of heparin-induced osteoporosis that low molecular weight heparin (LMWH) produces less bone loss than unfractionated heparin, and that only heparin increases osteoclast number and activity. In contrast, both heparin and LMWH were found to decrease osteoblast function to a sim...

journal_title：Thrombosis and haemostasis

authors： Bhandari M,Hirsh J,Weitz JI,Young E,Venner TJ,Shaughnessy SG

更新日期：1998-09-01 00:00:00

abstract：:Lysosomal Associated Membrane Protein-2 (LAMP-2) is an inherent component of lysosomal granule membranes in diverse cell types, including platelets. We examined platelets for evidence of LAMP-2 in dense granule membranes as CD63 has previously been shown to be present in both lysosomal and dense granule membranes. Imm...

journal_title：Thrombosis and haemostasis

authors： Israels SJ,McMillan EM,Robertson C,Singhory S,McNicol A

更新日期：1996-04-01 00:00:00

abstract：:Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involv...

journal_title：Thrombosis and haemostasis

authors： Lethagen S,Isaksson C,Schaedel C,Holmberg L

更新日期：2002-09-01 00:00:00

abstract：:Heparin-coating improves the biocompatibility of blood contacting artificial surfaces. This led us to investigate the impact of heparin-coating (Carmeda AB, Stockholm) of polymetylmetacrylate on the expression of monocyte tissue factor procoagulant activity (TF-PCA) by surface adhesion. Also, the anticoagulant effect ...

journal_title：Thrombosis and haemostasis

authors： Barstad RM,Hamers MJ,Møller AS,Sakariassen KS

更新日期：1998-02-01 00:00:00

abstract：:Hyperinsulinemia predicts future cardiovascular events, but may also contribute to atherosclerosis. We therefore studied the consequences of prolonged insulin treatment of human umbilical vein endothelial cells (HUVEC) on the phosphatidylinositol-3'-kinase(PI3K)/Akt/nitric oxide(NO)-dependent insulin signaling, togeth...

journal_title：Thrombosis and haemostasis

authors： Madonna R,De Caterina R

更新日期：2009-02-01 00:00:00

abstract：:Serum amyloid P component (SAP), and its acute phase homologue C-reactive protein (CRP), prolonged activated partial thromboplastin times (APTT) in cell free plasma when assayed at physiological concentrations in the presence of heparin. SAP also inhibited clot formation initiated through the extrinsic and terminal ph...

journal_title：Thrombosis and haemostasis

authors： Fiedel BA,Ku CS

更新日期：1986-06-30 00:00:00

abstract：:The ARISTOTLE trial showed a risk reduction of stroke/systemic embolism (SE) and major bleeding in non-valvular atrial fibrillation (NVAF) patients treated with apixaban compared to warfarin. This retrospective study used four large US claims databases (MarketScan, PharMetrics, Optum, and Humana) of NVAF patients newl...

journal_title：Thrombosis and haemostasis

authors： Li XS,Deitelzweig S,Keshishian A,Hamilton M,Horblyuk R,Gupta K,Luo X,Mardekian J,Friend K,Nadkarni A,Pan X,Lip GYH

更新日期：2017-06-02 00:00:00

abstract：:Previous studies on recombinant human soluble thrombomodulin (rsTM) from Chinese hamster ovary cells revealed that rsTM was expressed as two proteins that differed functionally in vitro due to the presence (rsTM beta) or absence (rsTM alpha) of chondroitin-4-sulfate. The current study evaluates the in vivo behavior of...

journal_title：Thrombosis and haemostasis

authors： Nawa K,Itani T,Ono M,Sakano K,Marumoto Y,Iwamoto M

更新日期：1992-03-02 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1) controls the regulation of the fibrinolytic system in blood by inhibiting both urokinase-type and tissue-type plasminogen activators. Enhanced levels of PAI-1 are related to pathological conditions associated with hypoxia or hyperinsulinemia. In this study, we investigated the...

journal_title：Thrombosis and haemostasis

authors： Dimova EY,Jakubowska MM,Kietzmann T

更新日期：2007-08-01 00:00:00

abstract：:It was found that the effect of heparin on the amidase activity of urokinase (E C 3.4.21.31), plasmin (E C 3.4.21.7) and trypsin (E C 3.4.21.4) depended on the substrate used. No effect of heparin on the amidase activity of urokinase and trypsin was observed when Pyro Glu-Gly-Arg-p-nitroanilide (S-2444) and alpha-N-ac...

journal_title：Thrombosis and haemostasis

authors： Yomtova VM,Stambolieva NA,Blagoev BM

更新日期：1983-06-28 00:00:00

abstract：:We reported previously that plasma fibrinogen was significantly higher in U.S. Caucasians than in Japanese, which may contribute to the higher mortality rate of coronary heart disease in the United States than in Japan. To examine the contribution of genetic variations to the race difference in plasma fibrinogen level...

journal_title：Thrombosis and haemostasis

authors： Iso H,Folsom AR,Winkelmann JC,Koike K,Harada S,Greenberg B,Sato S,Shimamoto T,Iida M,Komachi Y

更新日期：1995-01-01 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Niewiarowski S,Rucinski B,Budzynski AZ

更新日期：1979-07-01 00:00:00

abstract：:Two novel polymorphisms were identified in the factor V gene by direct sequencing of intronic areas. One of them, located in intron 9, is the marker closest to the Leiden mutation ever described, whereas the other, in intron 16, displays a rare allele invariantly associated to the mutation. Allele-specific amplificati...

journal_title：Thrombosis and haemostasis

authors： Castoldi E,Lunghi B,Mingozzi F,Ioannou P,Marchetti G,Bernardi F

更新日期：1997-09-01 00:00:00

abstract：:Some correlations between plasma and platelet fatty acids (FA) were evaluated "ex vivo" in 94 normal subjects. The highest relationships between total FA from plasma and platelets were found for 18:1 (r = 0.74) and 18:2 (r = 0.67). Low correlations were obtained for free fatty acids (FFA). The most significant correla...

journal_title：Thrombosis and haemostasis

authors： Vallés J,Aznar J,Santos MT

更新日期：1984-12-29 00:00:00

abstract：:We studied the effect of purified immunoglobulins (Ig) from 21 patients with antiphospholipid antibodies (aPL) on factor Va degradation by activated protein C (aPC) on cultured human umbilical vein endothelial cells (HUVEC). Sera from patients were tested on an ELISA aPL assay to determine the isotype with aPL activit...

journal_title：Thrombosis and haemostasis

authors： Borrell M,Sala N,de Castellarnau C,Lopez S,Gari M,Fontcuberta J

更新日期：1992-09-07 00:00:00

abstract：:Congenitally abnormal fibrinogen Osaka III with the replacement of gamma Arg-275 by His was found in a 38-year-old female with no bleeding or thrombotic tendency. Release of fibrinopeptide(s) by thrombin or reptilase was normal, but her thrombin or reptilase time in the absence of calcium was markedly prolonged and th...

journal_title：Thrombosis and haemostasis

authors： Yoshida N,Imaoka S,Hirata H,Matsuda M,Asakura S

更新日期：1992-11-10 00:00:00

abstract：:The platelet integrin alpha(IIb)beta(3) mediates the final step of platelet aggregation that requires pre-activation through an inside-out signal initiated by agonists. Experiments conducted under static conditions using platelet-rich plasma show that platelet activation and adhesion activity of alpha(IIb)beta(3) are ...

journal_title：Thrombosis and haemostasis

authors： Ball C,Vijayan KV,Nguyen T,Anthony K,Bray PF,Essex DW,Dong JF

更新日期：2008-11-01 00:00:00

abstract：:Coumarin and homologous compounds are the most widely used anticoagulant drugs worldwide. They function as antagonists of vitamin K, an essential cofactor for the posttranslational gamma-glutamyl carboxylation of the so-called vitamin K-dependent proteins. As vitamin K hydroquinone is converted to vitamin K epoxide (V...

journal_title：Thrombosis and haemostasis

authors： Rost S,Fregin A,Hünerberg M,Bevans CG,Müller CR,Oldenburg J

更新日期：2005-10-01 00:00:00

abstract：:Aspirin prevents thrombotic events by inhibiting platelet cyclooxygenase-1 (COX-1), thus reducing thromboxane A2 formation and platelet aggregation. The C50T polymorphism of COX-1 is associated with an impaired inhibition of both thromboxane production and in-vitro platelet aggregation by aspirin. We studied whether t...

journal_title：Thrombosis and haemostasis

authors： Clappers N,van Oijen MG,Sundaresan S,Brouwer MA,Te Morsche RH,Keuper W,Peters WH,Drenth JP,Verheugt FW

更新日期：2008-07-01 00:00:00

abstract：:Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the pathophysiology of ischaemic heart disease. Clopidogrel and the novel intravenous antithrombotic agent AR-C69931MX act at the level of the platelet P2Y12 receptor, which is known to amplify platelet activatio...

journal_title：Thrombosis and haemostasis

authors： Storey RF,Judge HM,Wilcox RG,Heptinstall S

更新日期：2002-09-01 00:00:00

abstract：:A new immunoadsorbent-amidolytic assay (IAA) for the specific differential detection of two-chain urokinase-type plasminogen activator (tcu-PA) and its single-chain precursor (scu-PA) in cell culture supernatants has been developed. The assay combines the selectivity of immunoassays with the specificity of enzyme acti...

journal_title：Thrombosis and haemostasis

authors： Corti A,Nolli ML,Cassani G

更新日期：1986-12-15 00:00:00

abstract：:Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

journal_title：Thrombosis and haemostasis

authors： Furlan M,Rupp C,Beck EA,Svendsen L

更新日期：1982-04-30 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction that occurs following exposure to unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). HIT with thrombosis (HITT) can cause devastating venous thromboembolism or arterial clots, prolonged hospitalization, and increased c...

journal_title：Thrombosis and haemostasis

authors： Baroletti S,Piovella C,Fanikos J,Labreche M,Lin J,Goldhaber SZ

更新日期：2008-12-01 00:00:00

abstract：:Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domain...

journal_title：Thrombosis and haemostasis

authors： Sarafanov AG,Makogonenko EM,Andersen OM,Mikhailenko IA,Ananyeva NM,Khrenov AV,Shima M,Strickland DK,Saenko EL

更新日期：2007-12-01 00:00:00

abstract：:alpha-Granule protein storage is important for producing platelets with normal haemostatic function. The low to undetectable levels of several megakaryocyte-synthesized alpha-granule proteins in normal plasma suggest megakaryocytes are important to sequester these proteins in vivo. alpha-Granule protein storage in vit...

journal_title：Thrombosis and haemostasis

authors： Veljkovic DK,Cramer EM,Alimardani G,Fichelson S,Massé JM,Hayward CP

更新日期：2003-11-01 00:00:00

abstract：:Several members of a family from Scranton, Pennsylvania were identified to have normal levels of prothrombin antigen while their prothrombin clotting activity was approximately 50% of normal. There has been no previous history of bleeding or other clinical manifestations in this family. The genomic DNA from the proban...

journal_title：Thrombosis and haemostasis

authors： Sun WY,Smirnow D,Jenkins ML,Degen SJ

更新日期：2001-04-01 00:00:00

abstract：:Hematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. ...

journal_title：Thrombosis and haemostasis

authors： Ruan C,Wu Y,Okada T,Motoi S,Kondo T,Jiang M,Xin X,Peng L,Ichihara K,Ikeda Y

更新日期：2002-07-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00