Cerebral venous sinus (sinovenous) thrombosis in children.

Abstract:

:Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associated with neonatal CSVT. Although there is considerable overlap in risk factors for CSVT in neonates and older infants and children, specific differences exist between the groups. Clinical symptoms are frequently nonspecific, which may obscure the diagnosis and delay treatment. While morbidity and mortality are significant, CSVT recurs less commonly than arterial ischemic stroke in children. Appropriate management may reduce the risk of recurrence and improve outcome, however there are no randomized controlled trials to support the use of anticoagulation in children. Although commonly employed in many centers, this practice remains controversial, highlighting the continued need for high-quality studies. This article reviews the literature pertaining to pediatric venous sinus thrombosis.

journal_name

Neurosurg Clin N Am

authors

Dlamini N,Billinghurst L,Kirkham FJ

doi

10.1016/j.nec.2010.03.006

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

511-27

issue

3

eissn

1042-3680

issn

1558-1349

pii

S1042-3680(10)00028-8

journal_volume

21

pub_type

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