Histology and molecular aspects of central neurocytoma.

Abstract:

:Central neurocytoma (CN) is a well-differentiated tumor of neural cells occurring within the ventricles. It is composed of monomorphic cells with round, regular nuclei within clear cytoplasm and must be distinguished from other clear cell tumors. Immunohistochemical markers of CN that aid in diagnosis include synaptophysin and neuronal nuclear antigen. The molecular biology of these tumors is becoming increasingly elucidated, particularly with the use of microarray analyses. Several oncogenic pathways have been suggested by these studies. Although progress continues to be made, knowledge of CN has yet to dictate targeted therapies in treating patients with these tumors.

journal_name

Neurosurg Clin N Am

authors

Bonney PA,Boettcher LB,Krysiak RS 3rd,Fung KM,Sughrue ME

doi

10.1016/j.nec.2014.09.001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

21-9

issue

1

eissn

1042-3680

issn

1558-1349

pii

S1042-3680(14)00096-5

journal_volume

26

pub_type

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