Abstract:
:Central neurocytoma (CN) is a well-differentiated tumor of neural cells occurring within the ventricles. It is composed of monomorphic cells with round, regular nuclei within clear cytoplasm and must be distinguished from other clear cell tumors. Immunohistochemical markers of CN that aid in diagnosis include synaptophysin and neuronal nuclear antigen. The molecular biology of these tumors is becoming increasingly elucidated, particularly with the use of microarray analyses. Several oncogenic pathways have been suggested by these studies. Although progress continues to be made, knowledge of CN has yet to dictate targeted therapies in treating patients with these tumors.
journal_name
Neurosurg Clin N Amjournal_title
Neurosurgery clinics of North Americaauthors
Bonney PA,Boettcher LB,Krysiak RS 3rd,Fung KM,Sughrue MEdoi
10.1016/j.nec.2014.09.001subject
Has Abstractpub_date
2015-01-01 00:00:00pages
21-9issue
1eissn
1042-3680issn
1558-1349pii
S1042-3680(14)00096-5journal_volume
26pub_type
杂志文章,评审abstract::Treatment of dystonia refractory to oral medications or botulinum toxin injections includes the use of deep brain stimulation (DBS). Expectations should be established based on patient-related factors, including type of dystonia, genetic cause, target symptoms, age at the time of surgery, disease duration, or the pres...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2013.08.014
更新日期:2014-01-01 00:00:00
abstract::Our present treatment strategy for treating pineal region tumors is shown in Figure 5. We believe that stereotactic biopsy should be the first procedure in pineal region tumors so that a histologic diagnosis can be obtained. Based on the biopsy findings, the appropriate subsequent therapy, whether microsurgery, fracti...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Functional brain imaging studies of memory and attention with positron emission tomography and functional magnetic resonance imaging demonstrate involvement of specific regions of the normal human brain. Possible anatomical substrates for different types of memory have been identified. Different aspects of attention m...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::Endovascular embolization is a frequently used adjunct to operative resection of meningiomas. Embolization may decrease intraoperative blood loss, operative time, and surgical difficulty associated with resection. The specific clinical applications of this treatment have not been defined clearly. Procedural indication...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2015.11.005
更新日期:2016-04-01 00:00:00
abstract::The management of fluid and electrolytes is an important aspect of the intensive care of patients with intracranial disease and injury because the central nervous system has a critical role in fluid and electrolyte and acid-base homeostasis. This article reviews fluids and electrolytes and acid-base balance, their com...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::Spinal laser interstitial thermal therapy (LITT) appears to be a promising novel modality for treatment of epidural metastatic spine disease in patients who are poor candidates for larger-scale oncologic spinal surgery and can act synergetically with spinal stereotactic radiosurgery to maximize local control and palli...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2017.05.006
更新日期:2017-10-01 00:00:00
abstract::Laser interstitial thermal therapy is a minimally invasive surgical alternative to craniotomy that uses laser light through a fiber optic probe placed within a target lesion to create thermal tissue damage, resulting in cellular death. It is used in neuro-oncology to treat inaccessible lesions and obviate morbidity in...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2020.06.004
更新日期:2020-10-01 00:00:00
abstract::Glioblastoma multiforme is a malignant, relentless brain cancer with no known cure, and standard therapies leave significant room for the development of better, more effective treatments. Immunotherapy is a promising approach to the treatment of solid tumors that directs the patient's own immune system to destroy tumo...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2009.09.001
更新日期:2010-01-01 00:00:00
abstract::Glioblastoma (GBM) is infiltrative neoplasm with limited treatment options and poor overall survival. Stereotactic radiosurgery (SRS) allows spatially precise and conformal delivery of high doses of radiation. Salvage SRS for locally recurrent GBM was shown to improve patient survival and have more favorable safety pr...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2020.08.007
更新日期:2021-01-01 00:00:00
abstract::In this era of modern neurosurgery, we are able to provide adequate amelioration of disabling symptoms for the small subset of patients who have conditions that may make them unacceptable candidates for invasive stereotactic neurosurgical intervention. Gamma Knife radiosurgical thalamotomy is an effective and useful a...
journal_title:Neurosurgery clinics of North America
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
abstract::Medical errors are common and dangerous, estimated to cause over 400,000 deaths per year in the United States alone. The field of neurosurgery is not immune to these errors, and many studies have begun analyzing the frequency and types of errors that neurosurgical patients experience, along with their effects and caus...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2014.11.011
更新日期:2015-04-01 00:00:00
abstract::This article presents an overview of spinal neurocytomas. A rare manifestation of an uncommon tumor, extraventricular neurocytomas (EVNs) should be included in the differential for spinal intradural and intramedullary tumors. Spinal EVNs are generally benign with an indolent pathologic course but may display a variety...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2014.09.005
更新日期:2015-01-01 00:00:00
abstract::Spinopelvic fixation techniques are evolving and now seem to be converging. Good S1 pedicle fixation is the initial key anchor point. The tricortical technique tests out as the best. Supplemental fixation options are available. The most efficacious seems to be iliac fixation, followed by two-level structural interbody...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2007.02.009
更新日期:2007-04-01 00:00:00
abstract::Although craniofacial problems are commonly detected during the neonatal period, only a selected subgroup of lesions require early intervention. Such lesions are characterized either by their potential for causing early neurologic impairment, infection, or other severe sequelae if treatment is delayed or by the fact t...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Interest in surgery for focal cortical dysplasia has grown with the enhanced ability to detect these lesions preoperatively with modern imaging techniques. This article focuses on the surgical management of epilepsy associated with focal cortical dysplasia. The authors highlight the approaches practiced at Yale Univer...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章
doi:10.1016/s1042-3680(02)80010-9
更新日期:2002-01-01 00:00:00
abstract::Patients with symptomatic instability of the spine may be treated surgically with interbody fusion. Cost and complexity in this procedure arises owing to the implanted materials involved with facilitating fusion such as titanium or polyetheretherketone. Surface modifications have been developed to augment these base m...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2019.08.007
更新日期:2020-01-01 00:00:00
abstract::Skull base metastases (SBM) are rare among all tumors affecting the base of the skull. Because of their rarity, they have received limited attention in the published medical literature. Several clinical syndromes associated with SBM have been described. Knowledge of these syndromes and maintenance of a high index of s...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2010.08.005
更新日期:2011-01-01 00:00:00
abstract::Recent evidence supports the notion that the incidence of Cushing disease is higher than previously thought. Transphenoidal surgery, in the hands of experienced neurosurgeons, is currently considered the first-line treatment of choice. However, an examination of remission and recurrence rates in long-term follow-up st...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2012.06.012
更新日期:2012-10-01 00:00:00
abstract::Hemostasis is a cell-based process that is regulated in a tissue-specific manner by the differential expression of procoagulant and anticoagulant factors on endothelial cells from different sites throughout the vasculature. The central nervous system, in particular, exhibits unique mechanisms of hemostatic regulation ...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2018.05.001
更新日期:2018-10-01 00:00:00
abstract::For nearly a century, neurosurgeons have been involved in the use of therapeutic radiation. Long before there was a separate discipline of radiology or radiation therapy, pioneers such as Cushing and Frasier explored the effects of X-rays and radium on patients with brain tumors and arteriovenous malformations. This i...
journal_title:Neurosurgery clinics of North America
pub_type: 历史文章,杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::In the normal growth of the cranial base, an outline of prenatal development stressed the common vertebrate plan, the patterning of mesenchymal tissues formed from and influenced by migrating neural crest cells. Details are given of the sequences of chondrification and ossification. Postnatal growth is approached in t...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
abstract::Widespread adoption of electronic medical records (EMRs) in the United States is transforming the practice of medicine from a paper-based cottage industry into an integrated health care delivery system. Most physicians and institutions view the widespread use of EMRs to be inevitable. But the transformation has not be...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2014.11.018
更新日期:2015-04-01 00:00:00
abstract::This article reviews the authors' experience with image-guided surgery for brain metastases and discusses specifically the impact of the frameless viewing wand system on standard craniotomy techniques for this disorder. Topics discussed include patient selection, interactive image-guided neurosurgical resection of bra...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Medial temporal lobe epilepsy associated with mesial temporal sclerosis (MTS) is perhaps the most well-defined epilepsy syndrome that is responsive to structural interventions such as surgery. Several minimally invasive techniques have arisen that provide additional options for the treatment of MTS while potentially a...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2015.08.011
更新日期:2016-01-01 00:00:00
abstract::Cervical spina bifida, either occult or overt, is relatively uncommon. These lesions tend to be associated with other abnormalities of the central nervous system and spine. For the occult dysraphic lesions, a Klippel-Feil syndrome is a particular association, especially the type I variety. For the spina bifida cystica...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1995-04-01 00:00:00
abstract::The refinement in the intravascular techniques has revolved upon the development of new material and a better understanding of neurophysiology. Access has become less of a limitation, and more emphasis is now placed on getting the job done: closing a fistula, obliterating a malformation, or filling an aneurysm. Emboli...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
abstract::This article reviews the role of modalities that directly monitor brain parenchyma in patients with severe traumatic brain injury. The physiology monitored involves compartmental and perfusion pressures, tissue oxygenation and metabolism, quantitative blood flow, pressure autoregulation, and electrophysiology. There a...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2016.05.010
更新日期:2016-10-01 00:00:00
abstract::Invasive electroencephalography via subdural implanted electrodes is essential for the identification and localization of the epileptogenic focus in a large percentage of cases of medically refractory epilepsy. The implantation of subdural electrodes constitutes a widely used method for the preoperative investigation ...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.nec.2011.07.009
更新日期:2011-10-01 00:00:00
abstract::The technique of stereotactic proton radiosurgery is discussed in depth in this article. The physics of the proton beam in radiosurgery is explained, and the different factors of beam delivery are examined. These key factors (correspondence to shape, accuracy of delineation of volume, correspondence to volume, and acc...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Carotid occlusive disease remains an important cause of ischemic stroke. The results of large, randomized, clinical trials have established the benefit of surgical revascularization in patients with symptomatic or asymptomatic carotid stenosis. The introduction of balloon angioplasty and stenting of the extracranial c...
journal_title:Neurosurgery clinics of North America
pub_type: 杂志文章
doi:10.1016/j.nec.2008.07.011
更新日期:2008-07-01 00:00:00