Radiosurgery for Glioblastoma.

Abstract:

:Glioblastoma (GBM) is infiltrative neoplasm with limited treatment options and poor overall survival. Stereotactic radiosurgery (SRS) allows spatially precise and conformal delivery of high doses of radiation. Salvage SRS for locally recurrent GBM was shown to improve patient survival and have more favorable safety profile than repeated surgical resection. Boost SRS after fractionated radiation therapy is sometimes attempted; however, Radiation Therapy Oncology Group 93-05 randomized clinical trial did not demonstrate benefits of upfront SRS that was administered before fractionated radiation. Administration of bevacizumab with SRS is associated with improved survival and can allow SRS dose escalation.

journal_name

Neurosurg Clin N Am

authors

Bunevicius A,Sheehan JP

doi

10.1016/j.nec.2020.08.007

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

117-128

issue

1

eissn

1042-3680

issn

1558-1349

pii

S1042-3680(20)30085-1

journal_volume

32

pub_type

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