Abstract：
:This publication is a report on the workshop "The use of biomarkers for risk assessment" which took place in November 2007 in Prague, the Czech Republic. The main aim of the workshop was to bring together a broad international audience with a particular interest in the development and application of human biomonitoring (HBM) and biomarkers for environmental health research, and to provide a state-of-the art overview of the potential values and pitfalls of biomarkers in risk assessment. Throughout the presentations and the subsequent discussions, it was shown that human biomonitoring is a highly plastic and versatile tool for the unraveling of the link between contaminants in the environment and potentially associated health effects in the general population. Although it offers a means to integrate exposure through different environmental compartments, to integrate exposure over time, to include individual risk factors and genetic susceptibility, exposure biomarkers would greatly benefit from standardized, accurate and sensitive detection methods and toxicokinetic data. Effect biomarkers on the other hand need to be put into their relevant public health perspective, and well validated, mechanistically sound dose-response relationships are essential. New developments, such as in vitro assays and "-omics", may drastically improve our knowledge on the causal mechanisms behind environmental health associations and will allow for a more informed linkage of toxicological and epidemiological reality.
journal_name
Int J Hyg Environ Healthauthors
Smolders R,Bartonova A,Boogaard PJ,Dusinska M,Koppen G,Merlo F,Sram RJ,Vineis P,Schoeters Gdoi
10.1016/j.ijheh.2010.05.006subject
Has Abstractpub_date
2010-09-01 00:00:00pages
395-400issue
5eissn
1438-4639issn
1618-131Xpii
S1438-4639(10)00055-6journal_volume
213pub_type
abstract：:Perfluorinated compounds are fully fluorinated anthropogenic substances that have been used in various products, applications, and industrial processes. Due to their persistence and toxic effects, some of them are restricted, and therefore replacement products have been developed. The aim of the study was to quantify ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.12.014
更新日期：2017-04-01 00:00:00
abstract：:Possible adverse health effects of exposure to electric, magnetic and electromagnetic fields (EMF), and especially the question of whether there exists a special vulnerability of children, have been a much discussed topic during the last two decades. Static fields produce health effects only in very rare and exception...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2007.07.007
更新日期：2007-10-01 00:00:00
abstract：:The beneficial effect of trans-resveratrol (RESV) on health is well documented. Our aim was to study the putative preventive effect of RESV on the cytotoxicity of frequently used herbicides (alachlor, acetochlor). Estrogen receptor positive (ER+) MCF-7 human mammary carcinoma, HepG2 (ER+) human hepatocellular carcinom...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2005.01.021
更新日期：2005-01-01 00:00:00
abstract：:The production and use of the plasticisers Hexamoll® DINCH (di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate) and DPHP (di-(2-propylheptyl) phthalate) have increased after both chemicals were introduced into the market in the early 2000s as substitutes for restricted high molecular weight phthalates. During the population...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2019.09.004
更新日期：2020-08-01 00:00:00
abstract：:It is a weak point of environmental medicine that health disturbances, e.g. functional affections of the upper respiratory tract, cannot be objectively judged by physicians resp. researchers. In this study, the validity of acoustic rhinometry, a method giving information on cross-sectional areas of the upper airways b...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/S1438-4639(04)70008-5
更新日期：2000-03-01 00:00:00
abstract：:Whereas several studies evaluate MRSA in inpatients, for outpatients there are merely expert recommendations, but no systematic studies. Mostly, MRSA in outpatients is tolerated but not eradicated. Particularly, for risk patients with chronic wounds some experts postulate that MRSA-eradication is even impossible. For ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.01.001
更新日期：2010-03-01 00:00:00
abstract：UNLABELLED:The objective of the study was to measure the indoor air quality in classrooms with special emphasis on particulate matter (PM 10) and carbon dioxide (CO(2)) and the impact of cleaning and ventilation. MATERIAL AND METHOD:PM 10 was analysed via gravimetric method and by laser beam technology. CO(2) was anal...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2007.09.011
更新日期：2009-01-01 00:00:00
abstract：:As part of an investigation of the total indoor exposure of residents in PCB contaminated apartments in a building estate in Denmark, 73 homes were visited. Samples of air, vacuum cleaner dust and surface wipes were taken and analysed for 15 PCB congeners. The 53 apartments located in high-rise buildings with indoor P...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2019.113429
更新日期：2020-08-01 00:00:00
abstract：:This cross-sectional study examined the association between blood lead levels and neuropsychological and behavioural problems of 533 schoolgirls (6-12 years of age) who attended public schools in Riyadh, Capital of Saudi Arabia. Regression models were used to determine the best predictors of Beery VMI Saudi-based stan...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00091
更新日期：2001-11-01 00:00:00
abstract：:Many studies have found that household access to water supplies near or within the household plot can reduce the probability of diarrhea, trachoma, and other water-related diseases, and it is generally accepted that on-plot water supplies produce health benefits for households. However, the body of research literature...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2016.04.008
更新日期：2016-07-01 00:00:00
abstract：:Due to the frequent use of antibiotics and recurring illnesses related to multidrug-resistant (MDR) bacteria in South Africa, we determined if MDR Escherichia coli were present in pit latrine fecal sludge samples obtained from a peri-urban community in KwaZulu-Natal, South Africa. The abundance of E. coli in pit latri...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.08.002
更新日期：2017-11-01 00:00:00
abstract：:We examined relationships between exposure to residential pesticides, chemicals, dusts, fumes, and metals, and childhood germ cell tumors (GCTs) in the largest case-control study to date on the topic. We recruited 272 children under 15 years old who had GCT diagnosed between January 1, 1993 and December 31, 2001. Cont...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2005.08.001
更新日期：2006-01-01 00:00:00
abstract：:In Western Hemisphere arctic regions, scientific findings in humans, wildlife, and the environment have resulted in major governmental policy formulations. Government policy resulted in establishment of an effective international organization to address scientifically identified problems, including health disparities ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00231
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND AND AIM:Moderate fish consumption is recommended for prevention of coronary heart disease (CHD) as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have known beneficial effects on risk factors such as reducing blood pressure (BP) and increasing paraoxonase-1 (PON-1) activity. However concomitant m...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.11.004
更新日期：2017-04-01 00:00:00
abstract：:The body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like (dl-PCBs) and non-dioxin-like (ndl-PCBs) polychlorinated biphenyls, and polybrominated diphenyl ethers (PBDEs) was determined in blood samples from 70 subjects between 4 and 76 years old. The participants of the study were re...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2014.07.004
更新日期：2015-01-01 00:00:00
abstract：:Metabolites of di-(2-ethylhexyl) terephthalate (DEHTP), a substitute for ortho-based phthalate plasticisers like di-(2-ethylhexyl) phthalate (DEHP), were analysed in 2112 first-morning void urine samples from children and adolescents aged 3-17 years, participating in the population representative German Environmental ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2020.113589
更新日期：2020-08-21 00:00:00
abstract：BACKGROUND:The observed deficit of lung cancer in farmers has been partly attributed to exposure to organic dusts and endotoxins based largely on surrogate metrics. To move beyond these surrogates for etiological studies, we characterized task-based and time-weighted average (TWA) exposure to inhalable endotoxin, (1 → ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2020.113525
更新日期：2020-07-01 00:00:00
abstract：:We aim to explore the relationships between exposure to dampness, pets, and environmental tobacco smoke (ETS) early in life and asthma in Taiwanese children, and to discuss their links to early- and late-onset asthma. We conducted a 1:2 matched case-control study from the Taiwan Children Health Study, which was a nati...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2011.07.004
更新日期：2011-12-01 00:00:00
abstract：:Between January and October 1994, a study of the prevalence, intensity and clinical manifestations of onchocerciasis in nine communities of Toro local government area of Bauchi State, Nigeria was undertaken using the skin-snip method. Of the 1117 inhabitants examined, 188 (16.8%) were positive for microfilariae of Onc...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00052
更新日期：2001-07-01 00:00:00
abstract：:In this study, the concentrations of disinfection byproducts (DBPs), including trihalomethanes (THMs; chloroform, bromodichloromethane, dibromochloromethane, and bromoform), haloacetic acids (HAAs; dichloroacetic acid and trichloroacetic acid), haloacetonitriles (HANs; dichloroacetonitrile, trichloroacetonitrile, brom...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.09.005
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Some fragrance compounds are severe contact allergens. According to the so-called "26 allergens rule" (Article 1 (10) of Directive 2003/15/EC) (EC, 2003), 26 supposedly allergenic fragrances must be listed on the containers of cosmetics products if they are present above certain mass percentages in the produ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.04.001
更新日期：2010-07-01 00:00:00
abstract：:Piped drinking water is often considered a gold standard for protecting public health but research is needed to explicitly evaluate the effect of centralized treatment systems on water quality in developing world settings. This study examined the effect of a new drinking water treatment plant (DWTP) on microbial drink...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.01.010
更新日期：2017-04-01 00:00:00
abstract：:For the Ruhr River, bathing has been prohibited for decades. However, along with significant improvements of the hygienic water quality, there is an increasing demand of using the river for recreational purposes, in particular for bathing. In the "Safe Ruhr" interdisciplinary research project, demands, options and cha...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.07.007
更新日期：2016-10-01 00:00:00
abstract：:Brominated flame retardants (BFRs) are a large group of different substances used in numerous products to prevent fire hazards. Some of them are persistent in the environment, accumulate in the food chain and are of toxicological concern, while for others current data are limited. Meanwhile, BFRs have been found in ma...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2015.08.004
更新日期：2016-01-01 00:00:00
abstract：:The cross-sectional study investigated the impact of chronic low level arsenic (As) exposure (11-50μg/L) on CD14 expression and other inflammatory responses in rural women of West Bengal enrolled from control (As level <10μg/L; N, 131) and exposed area (As level 11-50μg/L, N, 142). Atomic absorption spectroscopy revea...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2015.06.003
更新日期：2015-08-01 00:00:00
abstract：:We conducted cost effectiveness analyses of four different CLTS interventions implemented in Ethiopia and Ghana. In each country, a pilot approach in which additional local actors were trained in CLTS facilitation was compared to the conventional approach. Data were collected using bottom-up costing, household surveys...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2020.113682
更新日期：2020-12-24 00:00:00
abstract：:The results of the study demonstrate that the weak estrogenic action of bisphenol A (a daily subcutaneous dose of 200 mg/kg on 4 consecutive days, administered before or after decidual induction that occurs on day 4 of pseudopregnancy) on deciduoma growth in pseudopregnant Sprague-Dawley rats, was functionally associa...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00115
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Conflicting evidence concerning possible harm from mercury (Hg) in regard to offspring cognition if the woman eats fish has prompted this study to examine evidence from a British pre-birth cohort to investigate the relationship between the two. METHODS:Pregnant women (median prenatal blood mercury 1.86μg/L)...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.07.004
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In utero exposure to perfluorooctanoic acid (PFOA) has been associated with decreases in birth weight. We aimed to estimate the proportion of PFOA-attributable low birth weight (LBW) births and associated costs in the US from 2003 to 2014, a period during which there were industry-initiated and...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.11.004
更新日期：2018-03-01 00:00:00
abstract：:Mixtures of methylisothiazolinone and methylchloroisothiazolinone are used as biocides in cosmetics, cleaning agents, and water-based paint. A biomonitoring method to evaluate exposure to these compounds was developed using N-methylmalonamic acid (NMMA), the main metabolite of both, methylisothiazolinone and methylchl...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2020.113511
更新日期：2020-06-01 00:00:00
