Abstract:
:Anaphylactic/anaphylactoid reaction to methotrexate (MTX) is uncommon. It may occur with the first dose (non-allergic reactions) or after a previous exposure to the drug (allergic or specific reactions). Desensitization has been shown effective in children with allergic-type reactions permitting the continuation of high-dose methotrexate (HDMTX) therapy. We report the case of a child with localized osteosarcoma who developed an anaphylactoid reaction after a first HDMTX course. A desensitization protocol was successfully applied allowing the administration of four additional courses. In our experience, desensitization can be a safe and effective procedure in children with anaphylactoid reactions to HDMTX.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
Oulego-Erroz I,Maneiro-Freire M,Bouzón-Alejandro M,Vázquez-Donsión M,Couselo JMdoi
10.1002/pbc.22616subject
Has Abstractpub_date
2010-09-01 00:00:00pages
557-9issue
3eissn
1545-5009issn
1545-5017journal_volume
55pub_type
杂志文章abstract:BACKGROUND:Chronic myeloid leukemia (CML) is a rare disease in children and represents approximately 2% of all childhood leukemia. This results in difficulty creating large cohorts of patients for pediatric CML research. The Glivec International Patient Assistance Program (GIPAP) is a patient-access program sponsored b...
journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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更新日期:2008-01-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2015-02-01 00:00:00
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journal_title:Pediatric blood & cancer
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pub_type: 杂志文章,多中心研究
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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更新日期:2008-01-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2011-12-15 00:00:00
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更新日期:2015-07-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2013-03-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2005-08-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2017-09-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2018-06-01 00:00:00
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更新日期:2018-06-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2013-01-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2012-10-01 00:00:00
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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更新日期:2005-11-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Pediatric blood & cancer
pub_type: 杂志文章,多中心研究
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更新日期:2009-09-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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