Disease association mapping in Drosophila can be replicated in the wild.

Abstract:

:Association and linkage mapping have become important tools in understanding the genetics of complex traits, including diseases in humans. As the success of association mapping is reduced by small effect sizes and limited power, linkage studies in laboratory-based model systems are still heavily used. But whether the results of these studies can be replicated in natural populations has been questioned. Here, we show that a polymorphism in the gene ref(2)P, which had previously been linked to sigma virus resistance in Drosophila melanogaster under laboratory conditions, also provides resistance against the virus in female flies in a wild population in the field. This genetic association is thus upheld in spite of a known genotype-by-genotype interaction and environmental variation.

journal_name

Biol Lett

journal_title

Biology letters

authors

Wilfert L,Jiggins FM

doi

10.1098/rsbl.2010.0329

subject

Has Abstract

pub_date

2010-10-23 00:00:00

pages

666-8

issue

5

eissn

1744-9561

issn

1744-957X

pii

rsbl.2010.0329

journal_volume

6

pub_type

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