Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions.

Abstract:

:Two non-coding DNA classes, introns and intergenic regions, of Drosophila melanogaster exhibit contrasting evolutionary patterns. GC content is significantly higher in intergenic regions and affects their degree of nucleotide variability. Divergence is positively correlated with recombination rate in intergenic regions, but not in introns. We argue that these differences are due to different selective constraints rather than mutational or recombinational mechanisms.

journal_name

Biol Lett

journal_title

Biology letters

authors

Ometto L,De Lorenzo D,Stephan W

doi

10.1098/rsbl.2006.0521

subject

Has Abstract

pub_date

2006-12-22 00:00:00

pages

604-7

issue

4

eissn

1744-9561

issn

1744-957X

pii

Y06K221805145633

journal_volume

2

pub_type

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