Bone resorption: supporting immunometabolism.

Abstract:

:Activation of the immune system is associated with an increase in the breakdown of various peripheral tissues, including bone. Despite the widely appreciated role of inflammatory mediators in promoting bone resorption, the functional value behind this process is not completely understood. Recent advances in the field of immunometabolism have highlighted the metabolic reprogramming that takes place in activated immune cells. It is now believed that the breakdown of peripheral tissue provides metabolic substrates to fuel metabolic anabolism in activated immune cells. We argue that phosphate, liberated by bone resorption, plays an indispensable role in sustaining immune cell metabolism. The liberated phosphate is then incorporated into macromolecules such as nucleotides and phospholipids, and is also used for the phosphorylation of metabolites (e.g. glycolytic intermediates). In addition, magnesium, also liberated during the breakdown of bone, is an essential cofactor required by various metabolic enzymes which are upregulated in activated immune cells. Finally, calcium activates various additional molecules involved in immune cell migration. Taken together, these factors suggest a key role for bone resorption during infection.

journal_name

Biol Lett

journal_title

Biology letters

authors

van Niekerk G,Mitchell M,Engelbrecht AM

doi

10.1098/rsbl.2017.0783

subject

Has Abstract

pub_date

2018-02-01 00:00:00

issue

2

eissn

1744-9561

issn

1744-957X

pii

rsbl.2017.0783

journal_volume

14

pub_type

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