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Improvement of neurological symptoms and memory and emotional status in a case of seronegative Sneddon syndrome with cyclophosphamide.

Abstract：

:Sneddon syndrome (SS) is characterized by livedo racemosa, recurrent ischemic strokes, and often progressive vascular dementia. Treatment options for SS center on either anticoagulation or immunosuppression to prevent strokes and to dissipate the skin findings, with these modalities based historically on the presence or absence of antiphospholipid antibodies (APA) respectively. However, few effective treatments have been reported to reverse the cognitive decline in SS. We report a case of a woman with seronegative SS (absence of APA) with cognitive decline who demonstrated objective and subjective improvements in her memory and emotional functioning after treatment with cyclophosphamide.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Hannon PM,Kuo SH,Strutt AM,York MK,Kass JS

doi

10.1016/j.clineuro.2010.04.002

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

544-7

issue

6

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(10)00104-6

journal_volume

112

pub_type

杂志文章

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