Abstract：
:Impaired hepatic detoxification capacity by cytochrome P450 subsystems has been implicated in the pathogenesis of Parkinson's disease. We have demonstrated that hepatic parahydroxylation of phenytoin (PHT) is impaired in patients with late-onset Parkinson's disease. In the present study, we have investigated the hypothesis that PHT parahydroxylation is even more impaired in patients with young-onset Parkinson's disease (age at onset before 40 years). We determined PHT parahydroxylation capacity in 21 patients with young-onset Parkinson's disease and 15 healthy age-matched controls. PHT parahydroxylation capacity was assessed by measuring the ratio of PHT to its major metabolite p-hydroxyphenyl-phenylhydantoin in serum 6 h after an oral test dose of 300 mg PHT. PHT parahydroxylation did not differ significantly between patients and controls. These results argue against the hypothesis that impaired activity of the cytochrome P450 isoenzyme responsible for PHT parahydroxylation is involved in the etiology of Parkinson's disease.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Peeters EA,Bloem BR,Kuiper MA,Vermeij P,de Wolff FA,Wolters EC,Roos RA,Ferrari MDdoi
10.1016/0303-8467(94)90117-1subject
Has Abstractpub_date
1994-11-01 00:00:00pages
296-9issue
4eissn
0303-8467issn
1872-6968pii
0303-8467(94)90117-1journal_volume
96pub_type
杂志文章abstract：:Calcitonin gene-related peptide (CGRP) antagonists have recently grabbed the attention of clinicians for migraine prophylaxis. The present meta-analysis aimed to assess the efficacy and safety of CGRP monoclonal antibodies (mAbs) in patients with chronic and episodic migraine using a systematic therapeutic regimen. Mo...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2020.105900
更新日期：2020-08-01 00:00:00
abstract：:We report a patient with the varicella zoster viral (VZV) infection of multiple cranial nerves mimicking Garcin syndrome, who initially presented with Ramsay Hunt syndrome (herpes zoster oticus). A 78-year-old man showed left facial palsy with zosteric eruptions in his left auricle and dysphagia, followed by left tota...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2005.09.002
更新日期：2006-12-01 00:00:00
abstract：:The endoscope has traditionally been used in neurosurgery to access a lesion within a natural body cavity. The challenge has been to access and resect deep-seated intraparenchymal lesions using a minimally invasive endoscopic technique. Endoscopic endonasal trans-sphenoidal surgery has gained increasing acceptance by ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2018.05.009
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVES:Several strokes of potential embolism do not clearly meet the definitions of embolic stroke with unknown source, cryptogenic stroke, or cardioembolic (CE) stroke. Considering the high mortality and recurrence of CE strokes, it is very important to detect treatable cardiac sources of embolism. Although region...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2020.105677
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abstract：OBJECTIVE:To evaluate the usefulness of serum and CSF adenosine deaminase (ADA) activity for the diagnosis of tuberculous meningitis (TBM) from other meningitis. METHODS:We studied CSF and serum ADA activity for 83 cases of TBM, 148 of bacterial meningitis (BM), and 262 of viral or aseptic meningitis. RESULTS:The mea...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2013.05.017
更新日期：2013-09-01 00:00:00
abstract：:Vasculitits of the central nervous system (CNS) is a known complication of chronic inflammatory bowel diseases. We report the case of a female patient with Crohn's disease, developing vasculitis of the CNS with evidence of pathological vessel depiction on magnetic resonance angiography. To our knowledge this is the fi...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2003.09.004
更新日期：2004-03-01 00:00:00
abstract：:Amongst the protean extra-intestinal manifestations of inflammatory bowel disease, scant mention is made of muscle involvement. This report outlines the clinical features, electrodiagnostic and muscle biopsy findings in a patient with ulcerative colitis who developed progressive proximal muscle weakness. The demonstra...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(87)80026-4
更新日期：1987-01-01 00:00:00
abstract：:Stroke in patients with cancer is different in terms of its etiology from stroke in the general population. Clinicians should be altered to the possibility of non-bacterial thrombotic endocarditis (NBTE), associated coagulopathy, and viable treatment options. We review the case of a 42-year-old woman with cerivcal car...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/0303-8467(93)90108-s
更新日期：1993-12-01 00:00:00
abstract：AIM:To assess health-related quality of life (HRQoL) in patients with DM1, to identify muscular, multisystemic, central and social factors that may affect QoL and to define a DM1 patient in risk of poor QoL. PATIENTS AND METHOD:This cross-sectional study comprised 120 DM1 consecutive patients. The following scales wer...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.05.015
更新日期：2013-03-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(83)90002-1
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To study the role of laser interstitial thermal therapy in recurrent glioblastoma and to assess its effect in the overall survival and in progression-free survival. METHODS:A MEDLINE and Pubmed search was performed for the key words "laser interstitial thermal therapy", "LITT" and "glioblastoma". Studies inv...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2018.02.038
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The incidence of chronic opioid use (COU) is increasing with health related complications impacting both patients and healthcare services. OBJECTIVE:The aim of this study was to identify the impact of COU on postoperative urinary retention (PUR) in patients following lumbar fusion surgery as well as its imp...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2020.106161
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and safety of pre-operative Halo-gravity traction in the treatment of severe neurofibromatosis type 1 and congenital scoliosis patients with thoracic rotatory subluxation. PATIENTS AND METHODS:Patients with neurofibromatosis type 1 and congenital scoliosis undergoing Halo-gravity tr...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2019.105548
更新日期：2019-12-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2008.03.010
更新日期：2008-07-01 00:00:00
abstract：:Clinical data demonstrate that there is a significant difference between at least two types of idiopathic Parkinsonian patients; a benign type of Parkinson's disease and a malignant type. They can be distinguished by the time course of a disability-score, independent of the duration of the disease. The benign cases re...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(79)90003-9
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:In this paper a new checklist (CLCE-24) for identification of cognitive and emotional problems after stroke is presented. The CLCE-24 is intended to support a clinical interview by health care professionals other than the trained (neuro)psychologist. METHODS:Patients were interviewed with the CLCE-24, 6 mont...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2006.10.002
更新日期：2007-04-01 00:00:00
abstract：:A case, in which rhinorrhoea was caused by a pituitary adenoma, is presented. Leakage of CSF or metrizamide could be observed on CT. ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(84)90278-6
更新日期：1984-01-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2018.01.001
更新日期：2018-02-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
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doi：10.1016/j.clineuro.2008.02.014
更新日期：2008-06-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2015.04.025
更新日期：2015-08-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2011.04.001
更新日期：2011-10-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2015.05.013
更新日期：2015-08-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2020.105719
更新日期：2020-05-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2020.106030
更新日期：2020-09-01 00:00:00
abstract：:The nature of the oropharyngeal dysphagia in polymyositis/dermatomyositis (PM/DM) has been investigated by EMG methods. Nineteen patients with PM/DM were studied. The oropharyngeal phase of swallowing was evaluated by the electrophysiological methods measuring the laryngeal relocation time, pharyngeal transit time and...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2004.02.024
更新日期：2004-12-01 00:00:00
abstract：OBJECT:In single patients with a cerebral aneurysm an external ventricular drain (EVD), an intracranial pressure (ICP) gauge or a combined EVD and ICP gauge placement is necessary after coil embolization and initiation of postprocedural anticoagulation. The aim of this study was to examine the hemorrhage rates of drain...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2013.01.023
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:Thromboembolic events, seizures, neurologic symptoms and adverse effects from corticosteroids and chemotherapies are frequent clinical complications seen in Glioblastoma (GB) patients. The exact impact these have on dismal patient outcome has not been fully elucidated. We aimed at assessing treatment associat...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2015.01.006
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The pathogenesis of frontal lobe atrophy (FLA) in stroke patients is unclear. We aimed to ascertain whether subcortical ischemic changes were more associated with FLA than with parietal lobe atrophy (PLA) and temporal lobe atrophy (TLA). METHODS:Brain magnetic resonance images (MRIs) from 471 Chinese ischem...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.08.019
更新日期：2009-12-01 00:00:00
abstract：:The Multiple Sleep Latency Test (MSLT) has gradually gained acceptance as an objective equivalent of the complaint of sleepiness. The history of this test and questions considering the validity of the MSLT in different situations are discussed. ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/0303-8467(92)90040-a
更新日期：1992-01-01 00:00:00
