Molecular attributes of human skeletal muscle at rest and after unaccustomed exercise: an age comparison.

Abstract:

:The current study examined muscle DNA and protein concentrations ([ ]) and the [RNA] (assumed to represent translational capacity), [RNA]:[DNA] (assumed to represent transcriptional efficiency) and [protein]:[RNA] (assumed to represent translational efficiency) in younger vs. older participants during a resting state. Further, changes in muscle [DNA], translational capacity, and transcriptional efficiency were analyzed 24 hours after an unaccustomed resistance exercise bout. Younger (20.9 +/- 0.5 years, 84.0 +/- 5.2 kg, 26.6 +/- 1.8 kg x m(-2); n = 13) and older men (67.6 +/- 1.3 years, 88.7 +/- 4.8 kg, 28.6 +/- 1.4 kg x m(-2); n = 13) reported to the laboratory and completed an unaccustomed bout of lower-body resistance training (i.e., 3 sets of 10 repetitions at 80% 1 repetition maximum for Smith squat, leg press, and leg extensions). Muscle biopsies from the vastus lateralis were obtained before and 24 hours after exercise. Baseline [RNA], [DNA], [protein], and [RNA]:[DNA] were not different between age groups (p > 0.05). Baseline [protein]:[RNA] was greater in younger vs. older men (p = 0.045), whereas 24-hour postexercise [RNA]:[DNA] tended to be greater in older men (p = 0.087). These findings suggest that a decrease in the efficiency of translational processes occurs in older human skeletal muscle, whereas global transcriptional processes appear to be unaltered when compared with those in younger men. In lieu of these data, it remains apparent that muscle-protein synthesis is impaired in aging skeletal muscle and effective countermeasures such as resistance exercise and nutritional adequacy must be undertaken by older populations to offset this phenomenon.

journal_name

J Strength Cond Res

authors

Roberts MD,Kerksick CM,Dalbo VJ,Hassell SE,Tucker PS,Brown R

doi

10.1519/JSC.0b013e3181da786f

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

1161-8

issue

5

eissn

1064-8011

issn

1533-4287

pii

00124278-201005000-00001

journal_volume

24

pub_type

杂志文章
  • The effects of amino acid supplementation on muscular performance during resistance training overreaching.

    abstract::The purpose of this study was to examine the effects of amino acid supplementation on muscular strength, power, and high-intensity endurance during short-term resistance training overreaching. Seventeen resistance-trained men were randomly assigned to either an amino acid (AA) or placebo (P) group and underwent 4 week...

    journal_title:Journal of strength and conditioning research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1519/1533-4287(2003)017<0250:teoaas>2.0.co;2

    authors: Ratamess NA,Kraemer WJ,Volek JS,Rubin MR,Gómez AL,French DN,Sharman MJ,McGuigan MM,Scheett T,Häkkinen K,Newton RU,Dioguardi F

    更新日期:2003-05-01 00:00:00

  • Strength and Conditioning Practices in Adolescent Rugby Players: Relationship With Changes in Physical Qualities.

    abstract::Weakley, JJS, Till, K, Darrall-Jones, J, Roe, GAB, Phibbs, PJ, Read, DB, and Jones, BL. Strength and conditioning practices in adolescent rugby players: relationship with changes in physical qualities. J Strength Cond Res 33(9): 2361-2369, 2019-Adolescent rugby players benefit from the implementation of resistance tra...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000001828

    authors: Weakley JJS,Till K,Darrall-Jones J,Roe GAB,Phibbs PJ,Read DB,Jones BL

    更新日期:2019-09-01 00:00:00

  • A physical profile of elite female ice hockey players from the USA.

    abstract::Despite impressive numbers of hockey participants, there is little research examining elite female ice hockey players. Therefore, the purpose of this study was to describe the physical characteristics of elite female ice hockey players who were trying out for the 2010 US Women's Ice Hockey team. Twenty-three women par...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0b013e31822a5440

    authors: Ransdell LB,Murray T

    更新日期:2011-09-01 00:00:00

  • The training effect of short term enhancement from complex pairing on horizontal and vertical countermovement and drop jump performance.

    abstract::The purpose of this study was to investigate the chronic effect of a contrast training program designed to elicit an acute short term enhancement (STE) effect during training. A matched pairs training study design was implemented with a contrast (STE affected) and complex (control) training group completing a seven we...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000000874

    authors: Dobbs CW,Gill ND,Smart DJ,McGuigan MR

    更新日期:2015-02-03 00:00:00

  • The effects of enforced, rapid deceleration on performance in a multiple sprint test.

    abstract::The nature of multiple sprint sports such as soccer, hockey, and rugby is such that deceleration plays an important part in the movement patterns of players during a game and training. The purpose of this study was to investigate the effect of deceleration on fatigue during repeated sprint efforts. A group of 18 elite...

    journal_title:Journal of strength and conditioning research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1519/1533-4287(2004)18<579:TEOERD>2.0.CO;2

    authors: Lakomy J,Haydon DT

    更新日期:2004-08-01 00:00:00

  • Acute effects of different warm-up protocols with and without a weighted vest on jumping performance in athletic women.

    abstract::The purpose of this study was to examine the acute effects of 3 different warm-up protocols with and without a weighted vest on vertical jump (VJ) and long jump (LJ) performance in athletic women. Sixteen subjects (19.7 +/- 1.4 years, 67.0 +/- 10.7 kg, 165.7 +/- 11.4 cm) participated in 3 testing sessions in random or...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/00124278-200702000-00010

    authors: Thompsen AG,Kackley T,Palumbo MA,Faigenbaum AD

    更新日期:2007-02-01 00:00:00

  • Internal and External Loads During Hockey 5's Competitions Among U16 Players.

    abstract::Konarski, JM, Konarska, A, Strzelczyk, R, Skrzypczak, M, and Malina, RM. Internal and external loads during Hockey 5's competitions among U16 players. J Strength Cond Res XX(X): 000-000, 2019-The purpose of the study was to characterize the external and internal loads associated with Hockey 5's, the modified small-sid...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000003251

    authors: Konarski JM,Konarska A,Strzelczyk R,Skrzypczak M,Malina RM

    更新日期:2019-07-31 00:00:00

  • Postactivation potentiation enhances swim performance in collegiate swimmers.

    abstract::This study examined postactivation potentiation (PAP) and its effect on performance during sprint swimming. After maximal muscular contraction, the muscles are in both a potentiated and fatigued state. However, fatigue dissipates faster than potentiation, creating a window of opportunity for possible performance enhan...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章,随机对照试验

    doi:10.1519/JSC.0000000000000744

    authors: Hancock AP,Sparks KE,Kullman EL

    更新日期:2015-04-01 00:00:00

  • Sex Comparison of Knee Extensor Size, Strength, and Fatigue Adaptation to Sprint Interval Training.

    abstract:ABSTRACT:Bagley, L, Al-Shanti, N, Bradburn, S, Baig, O, Slevin, M, and McPhee, JS. Sex comparison of knee extensor size, strength, and fatigue adaptation to sprint interval training. J Strength Cond Res 35(1): 64-71, 2021-Regular sprint interval training (SIT) improves whole-body aerobic capacity and muscle oxidative p...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000002496

    authors: Bagley L,Al-Shanti N,Bradburn S,Baig O,Slevin M,McPhee JS

    更新日期:2021-01-01 00:00:00

  • Effects of unilateral and bilateral lower-body heavy resistance exercise on muscle activity and testosterone responses.

    abstract::Unilateral and bilateral lower-body heavy resistance exercises (HREs) are used for strength training. Little research has examined whether muscle activation and testosterone (TES) responses differ between these exercises. Our purpose was to compare the effects of unilateral and bilateral lower-body HRE on muscle activ...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0b013e318248ab3b

    authors: Jones MT,Ambegaonkar JP,Nindl BC,Smith JA,Headley SA

    更新日期:2012-04-01 00:00:00

  • Relationship between upper-body strength and bat swing speed in high-school baseball players.

    abstract::This study aimed to clarify the relationship between upper-body strength and bat swing speed in high-school baseball players and to examine the physical characteristics of home run hitters (sluggers). The subjects were 30 male high-school baseball players with national tournament experience at the Koshien Stadium. Bat...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0b013e318236d126

    authors: Miyaguchi K,Demura S

    更新日期:2012-07-01 00:00:00

  • Asymmetries of Maximum Trunk, Hand, and Leg Strength in Comparison to Volleyball and Fitness Athletes.

    abstract::Mattes, K, Wollesen, B, and Manzer, S. Asymmetries of maximum trunk, hand, and leg strength in comparison to volleyball and fitness athletes. J Strength Cond Res 32(1): 57-65, 2018-Playing volleyball and corresponding training loads lead to specific strains and might result in asymmetric muscle pattern. The study aime...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000002183

    authors: Mattes K,Wollesen B,Manzer S

    更新日期:2018-01-01 00:00:00

  • Factor Structure and Internal Validity of the Functional Movement Screen in Adults.

    abstract::The factor structure and internal consistency of the Functional Movement Screen (FMS) have not been examined in a general healthcare population. Replicating the factor structure of the FMS is important because it illustrates the interdependence between each of the subtests, enabling the strength and conditioning profe...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000001092

    authors: Koehle MS,Saffer BY,Sinnen NM,MacInnis MJ

    更新日期:2016-02-01 00:00:00

  • Match-play activity profile in elite women's rugby union players.

    abstract::The aim of this study was to provide an objective description of the locomotive activities and exercise intensity undergone during the course of an international-level match of female rugby union. Eight players were analyzed using global positioning system tracking technology. The total distance covered by the players...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0b013e3182999e2b

    authors: Suarez-Arrones L,Portillo J,Pareja-Blanco F,Sáez de Villareal E,Sánchez-Medina L,Munguía-Izquierdo D

    更新日期:2014-02-01 00:00:00

  • Excess Blood Flow Response to Acute Resistance Exercise in Individuals Who are Obese or Nonobese.

    abstract::Lipford, GF, Evans, RK, Acevedo, EO, Wolfe, LG, and Franco, RL. Excess blood flow response to acute resistance exercise in individuals who are obese or nonobese. J Strength Cond Res 31(11): 3120-3127, 2017-Resistance exercise (RE) is a commonly recommended treatment option for obese individuals. However, little is kno...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000001748

    authors: Lipford GF,Evans RK,Acevedo EO,Wolfe LG,Franco RL

    更新日期:2017-11-01 00:00:00

  • Wearing a cooling jacket during exercise reduces thermal strain and improves endurance exercise performance in a warm environment.

    abstract::The aim of the present study was to investigate the effect of wearing a cooling jacket on thermoregulatory responses and endurance exercise performance in a warm environment. Nine untrained male subjects cycled for 60 minutes at 60% Vo(2)max (Ex1) and then immediately exercised to exhaustion at 80% Vo(2)max (Ex2) in 3...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/14503.1

    authors: Hasegawa H,Takatori T,Komura T,Yamasaki M

    更新日期:2005-02-01 00:00:00

  • Effect of Whole-Body Vibration on Neuromuscular Activation of Leg Muscles During Dynamic Exercises in Individuals With Stroke.

    abstract::Liao, L-R, and Pang, MYC. Effect of whole-body vibration on neuromuscular activation of leg muscles during dynamic exercises in individuals with stroke. J Strength Cond Res 31(7): 1954-1962, 2017-This study examined the leg muscle activity during exposure to different whole-body vibration (WBV) intensities while perfo...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000001761

    authors: Liao LR,Pang MYC

    更新日期:2017-07-01 00:00:00

  • Effect of Instructions on Selected Jump Squat Variables.

    abstract::Talpey, SW, Young, WB, and Beseler, B. Effect of instructions on selected jump squat variables. J Strength Cond Res 30(9): 2508-2513, 2016-The purpose of this study was to compare 2 instructions on the performance of selected variables in a jump squat (JS) exercise. The second purpose was to determine the relationship...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000000435

    authors: Talpey SW,Young WB,Beseler B

    更新日期:2016-09-01 00:00:00

  • A comparison of force curve profiles between the bench press and ballistic bench throws.

    abstract::The purpose of this study was to compare the peak force and force curve characteristics during a traditional bench press (BP) and a ballistic bench throw (BT). Eight (age = 21.0 +/- 2.3 years, height = 182.3 +/- 7.4 cm, body mass = 85.9 +/- 5.5 kg) semi-professional rugby league players with resistance and power train...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章,随机对照试验

    doi:10.1519/JSC.0b013e3181874735

    authors: Clark RA,Bryant AL,Humphries B

    更新日期:2008-11-01 00:00:00

  • High-Speed Resistance Training Modifies Load-Velocity and Load-Power Relationships in Parkinson's Disease.

    abstract::Muscle power is a major neuromuscular factor affecting motor function and independence in patients with Parkinson's disease (PD), and it is commonly targeted using high-speed exercise. This study examined the changes in velocities (Vpp) and percent loads (%1RMpp) at peak power and load-velocity (L-V) and load-power (L...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章,随机对照试验

    doi:10.1519/JSC.0000000000001730

    authors: Ni M,Signorile JF

    更新日期:2017-10-01 00:00:00

  • Effect of Rest Interval Duration on the Volume Completed During a High-Intensity Bench Press Exercise.

    abstract::Hernandez, DJ, Healy, S, Giacomini, ML, and Kwon, YS. Effect of rest interval duration on the volume completed during a high-intensity bench press exercise. J Strength Cond Res XX(X): 000-000, 2020-Between-set rest intervals (RIs) are one of the most important variables in resistance training; however, no known resear...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000003477

    authors: Hernandez DJ,Healy S,Giacomini ML,Kwon YS

    更新日期:2020-02-27 00:00:00

  • An Examination of Fatigue Index and Velocity-Related Force Loss for the Forearm Flexors.

    abstract::The purpose of this study was to examine the relationship between the fatigue index from an isokinetic fatigue test and the velocity-related decrease in peak torque for the forearm flexors. After a familiarization session, 13 habitually active males (mean ± SD, age = 23.8 ± 3.1 years) reported to the laboratory to per...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000000879

    authors: Carr JC,Beck TW,Ye X,Wages NP

    更新日期:2015-08-01 00:00:00

  • The Effect of Exertion and Sex on Vertical Ground Reaction Force Variables and Landing Mechanics.

    abstract::The purpose of this investigation was to determine how exertion and sex affected a variety of vertical ground reaction force (VGRF) parameters during a jump-landing task, including peak VGRF, peak VGRF asymmetry, loading rate, and loading rate asymmetry. Additionally, we wanted to determine whether landing mechanics c...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000001253

    authors: Bell DR,Pennuto AP,Trigsted SM

    更新日期:2016-06-01 00:00:00

  • Relationships Between Eccentric and Concentric Knee Strength Capacities and Maximal Linear Deceleration Ability in Male Academy Soccer Players.

    abstract:ABSTRACT:Harper, DJ, Jordan, AR, and Kiely, J. Relationships between eccentric and concentric knee strength capacities and maximal linear deceleration ability in male academy soccer players. J Strength Cond Res 35(2): 465-472, 2021-The purpose of this study was to investigate the relationships between maximal linear de...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000002739

    authors: Harper DJ,Jordan AR,Kiely J

    更新日期:2021-02-01 00:00:00

  • Acute and Long-Term Comparison of Fixed vs. Self-Selected Rest Interval Between Sets on Upper-Body Strength.

    abstract::Simão, R, Polito, M, de Salles, BF, Marinho, DA, Garrido, ND, Santos Junior, ERT, and Willardson, JM. Acute and long-term comparison of fixed vs. self-selected rest interval between sets on upper-body strength. J Strength Cond Res XX(X): 000-000, 2020-The effects of different rest interval durations between sets has b...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000003606

    authors: Simão R,Polito M,Freitas de Salles B,Marinho DA,Garrido ND,Junior ERTS,Willardson JM

    更新日期:2020-08-18 00:00:00

  • Familiarization and reliability of multiple sprint running performance indices.

    abstract::The aims of this study were to evaluate the time-course of the familiarization process associated with a test of multiple sprint running performance and to determine the reliability of various performance indices once familiarization had been established. Eleven physically active men (mean age: 21 +/- 2 years) complet...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/R-20336.1

    authors: Glaister M,Howatson G,Lockey RA,Abraham CS,Goodwin JE,McInnes G

    更新日期:2007-08-01 00:00:00

  • Short-term heavy resistance training eliminates age-related deficits in muscle mass and strength in healthy older males.

    abstract::The objective of this investigation was to determine whether short-term heavy resistance training (RT) in healthy older men could eliminate deficits in muscle mass and strength (ST) compared with healthy younger men. Seventeen older men (60-71 yr) performed supervised RT for 22 weeks. Before and after RT, measurements...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0b013e3181bf43c8

    authors: Candow DG,Chilibeck PD,Abeysekara S,Zello GA

    更新日期:2011-02-01 00:00:00

  • Strength, flexibility, and balance characteristics of highly proficient golfers.

    abstract::Despite the emergence of golf-specific training programs and training aids, relatively little research has been conducted examining the physical characteristics that are important to golf performance. We studied the strength, flexibility, and balance characteristics of golfers across 3 proficiency levels based on hand...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/R-21826.1

    authors: Sell TC,Tsai YS,Smoliga JM,Myers JB,Lephart SM

    更新日期:2007-11-01 00:00:00

  • Effect of ACTN3 Polymorphism on Self-reported Running Times.

    abstract::Kreutzer, A, Martinez, CA, Kreutzer, M, Stone, JD, Mitchell, JB, and Oliver, JM. Effect of ACTN3 polymorphism on self-reported running times. J Strength Cond Res 33(1): 80-88, 2019-This investigation examined the effect of ACTN3 genotype on self-reported distance running personal records (PRs). Of 94 (n = 94) recreati...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000002949

    authors: Kreutzer A,Martinez CA,Kreutzer M,Stone JD,Mitchell JB,Oliver JM

    更新日期:2019-01-01 00:00:00

  • Creatine Usage and Education of Track and Field Throwers at National Collegiate Athletic Association Division I Universities.

    abstract::The purpose of this study was to analyze the level of creatine use along with the perceived benefits and barriers of creatine use among collegiate athletes who participate in throwing events within the sport of track and field. A total of 258 throwers from National Collegiate Athletic Association Division I institutio...

    journal_title:Journal of strength and conditioning research

    pub_type: 杂志文章

    doi:10.1519/JSC.0000000000000818

    authors: Judge LW,Petersen JC,Craig BW,Hoover DL,Holtzclaw KA,Leitzelar BN,Tyner RM,Blake AS,Hindawi OS,Bellar DM

    更新日期:2015-07-01 00:00:00