Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase.

abstract：:Increases in inflammatory-cell progenitors have been demonstrated in the bone marrow (BM) after inhalation of Ascaris suum in dogs at the time of allergen-induced airway hyperresponsiveness (AHR). The aim of this study was to evaluate the effect of allergen challenge on trafficking of inflammatory cells and their prog...

journal_title：American journal of respiratory cell and molecular biology

authors： Wood LJ,Inman MD,Denburg JA,O'Byrne PM

更新日期：1998-06-01 00:00:00

abstract：:Pulmonary fibrosis (PF) is caused by a number of inhaled agents, as well as by some drugs and toxic particles. The elaboration of certain peptide growth factors is thought to be key to the development of this disease process. In addition, genetic susceptibility plays a role in the development of PF. For instance, we h...

journal_title：American journal of respiratory cell and molecular biology

authors： Warshamana GS,Pociask DA,Sime P,Schwartz DA,Brody AR

更新日期：2002-12-01 00:00:00

abstract：:We examined the ability of conditioned medium (CM) generated by human upper airway epithelial (Ep) cells from normal (NN) and inflamed, allergic rhinitis (AR) and nasal polyp (NP) tissues to induce monocytic differentiation of hemopoietic progenitors of the HL-60 myeloid leukemia cell line in vitro. In HL-60 cells cul...

journal_title：American journal of respiratory cell and molecular biology

authors： Ohtoshi T,Vancheri C,Cox G,Gauldie J,Dolovich J,Denburg JA,Jordana M

更新日期：1991-03-01 00:00:00

abstract：:We have previously shown that long-term treatment of airway smooth muscle (ASM) cells with a combination of TNF-alpha and IFN-gamma impaired steroid anti-inflammatory action through the up-regulation of glucocorticoid receptor beta isoform (GRbeta) (Mol Pharmacol 2006;69:588-596). We here found that steroid actions co...

journal_title：American journal of respiratory cell and molecular biology

authors： Tliba O,Damera G,Banerjee A,Gu S,Baidouri H,Keslacy S,Amrani Y

更新日期：2008-04-01 00:00:00

abstract：:The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Spalluto CM,Singhania A,Cellura D,Woelk CH,Sanchez-Elsner T,Staples KJ,Wilkinson TMA

更新日期：2017-10-01 00:00:00

abstract：:The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to account for the inability of current therapies to resolve bacterial infections in the lungs of patients with cystic fibrosis (CF). We recently described a system in which highly antibiotic-resistant P. aeruginosa biofilms grow on...

journal_title：American journal of respiratory cell and molecular biology

authors： Moreau-Marquis S,O'Toole GA,Stanton BA

更新日期：2009-09-01 00:00:00

abstract：:It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Weintraub SJ

更新日期：1996-08-01 00:00:00

abstract：:Protein kinase C (PKC) is known to regulate ryanodine receptor (RyR)-mediated local Ca(2+) signaling (Ca(2+) spark) in airway and vascular smooth muscle cells (SMCs), but its specific molecular mechanisms and functions still remain elusive. In this study, we reveal that, in airway SMCs, specific PKCepsilon peptide inh...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu QH,Zheng YM,Korde AS,Li XQ,Ma J,Takeshima H,Wang YX

更新日期：2009-06-01 00:00:00

abstract：:Interleukin-13 (IL-13) is one of the central mediators for development of airway hyperresponsiveness in asthma. However, its effect on bronchial smooth muscle (BSM) is not well known. Recent studies revealed an involvement of RhoA/Rho-kinase in BSM contraction, and this pathway has now been proposed as a new target fo...

journal_title：American journal of respiratory cell and molecular biology

authors： Chiba Y,Nakazawa S,Todoroki M,Shinozaki K,Sakai H,Misawa M

更新日期：2009-02-01 00:00:00

abstract：:Chemokine receptor (CCR) 5 is expressed on dendritic cells, macrophages, CD8 cells, memory CD4 T cells, and stromal cells, and is frequently used as a marker of T helper type 1 cells. Interventions that abrogate CCR5 or interfere with its ligand binding have been shown to alter T helper type 2-induced inflammatory res...

journal_title：American journal of respiratory cell and molecular biology

authors： Fuchimoto Y,Kanehiro A,Miyahara N,Koga H,Ikeda G,Waseda K,Tanimoto Y,Ueha S,Kataoka M,Gelfand EW,Tanimoto M

更新日期：2011-12-01 00:00:00

abstract：:The present study investigated mechanisms underlying apical and basolateral P2Y(1)-mediated Cl(-) secretion in human airway epithelial cells. Apical and basolateral ATP induced short-circuit currents (I(sc)) with different properties via P2Y(1) receptors. The former comprised an immediate rise followed by a slow atten...

journal_title：American journal of respiratory cell and molecular biology

authors： Son M,Ito Y,Sato S,Ishikawa T,Kondo M,Nakayama S,Shimokata K,Kume H

更新日期：2004-03-01 00:00:00

abstract：:Prior studies have demonstrated that human alveolar macrophages (AM) are suppressive of lymphocyte function, through the mechanism of inhibition is unclear. In the current study, human AM inhibited receptor-mediated increases in intracellular calcium concentration ([Ca2+]i) in T cells, natural killer cells, and B cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Yarbrough WC Jr,Wilkes DS,Weissler JC

更新日期：1991-11-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) or fibroblast growth factor (FGF)-7, a peptide produced by stromal cells and in particular by lung mesenchyme, has recently been shown to influence early lung morphogenesis and to be a mitogen for fetal and adult alveolar type II cells. Although contradictory findings have been reporte...

journal_title：American journal of respiratory cell and molecular biology

authors： Chelly N,Mouhieddine-Gueddiche OB,Barlier-Mur AM,Chailley-Heu B,Bourbon JR

更新日期：1999-03-01 00:00:00

abstract：:Endothelin, an endothelium-derived vasoconstrictor peptide, has recently been reported to exist in airway epithelial cells. To elucidate a possible role of endothelin on epithelial functions, we studied the effects of this peptide on ciliary beat frequency (CBF) and electrical properties of canine cultured tracheal ep...

journal_title：American journal of respiratory cell and molecular biology

authors： Tamaoki J,Kanemura T,Sakai N,Isono K,Kobayashi K,Takizawa T

更新日期：1991-05-01 00:00:00

abstract：:Macrophage inflammatory proteins 1 alpha and 2 (MIP-1 alpha, MIP-2) are members of a growing family of cytokines thought to play a role in host defense. MIP-1 alpha and MIP-2 were previously identified in the mouse and shown to stimulate inflammatory cell recruitment. To better understand the potential role of MIP-1 a...

journal_title：American journal of respiratory cell and molecular biology

authors： Driscoll KE,Hassenbein DG,Carter J,Poynter J,Asquith TN,Grant RA,Whitten J,Purdon MP,Takigiku R

更新日期：1993-03-01 00:00:00

abstract：:Persistent polyclonal lymphocytosis has been described in a group of female patients who all have the HLA-DR7 antigen in common and who are all heavy cigarette smokers. Immunoglobulin heavy chain gene rearrangement was analyzed by hybridization with specific immunoglobulin heavy chain genes to restriction enzyme-diges...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan MA,Benedict SH,Carstairs KC,Francombe WH,Gelfand EW

更新日期：1990-06-01 00:00:00

abstract：:The mammalian airways are sensitive to inhaled stimuli, and airway diseases are characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents, and others. However, the identity and function of the cells in the airway that can sense volatile chemicals remain uncertain, particularly in hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Gu X,Karp PH,Brody SL,Pierce RA,Welsh MJ,Holtzman MJ,Ben-Shahar Y

更新日期：2014-03-01 00:00:00

abstract：:Chlorine (Cl(2)) gas exposure poses an environmental and occupational hazard that frequently results in acute lung injury. There is no effective treatment. We assessed the efficacy of antioxidants, administered after exposure, in decreasing mortality and lung injury in C57BL/6 mice exposed to 600 ppm of Cl(2) for 45 m...

journal_title：American journal of respiratory cell and molecular biology

authors： Zarogiannis SG,Jurkuvenaite A,Fernandez S,Doran SF,Yadav AK,Squadrito GL,Postlethwait EM,Bowen L,Matalon S

更新日期：2011-08-01 00:00:00

abstract：:Mechanical stimulation of the airway epithelium, as would occur during bronchoconstriction, is a potent stimulus and can activate profibrotic pathways. We used DNA microarray technology to examine gene expression in compressed normal human bronchial epithelial cells (NHBE). Compressive stress applied continuously over...

journal_title：American journal of respiratory cell and molecular biology

authors： Chu EK,Cheng J,Foley JS,Mecham BH,Owen CA,Haley KJ,Mariani TJ,Kohane IS,Tschumperlin DJ,Drazen JM

更新日期：2006-12-01 00:00:00

abstract：:Extensive tissue remodeling occurs in survivors of acute lung injury, leading to nearly normal histology and physiology in the majority of individuals, whereas others suffer significant impairment due to the development of pulmonary fibrosis. Alveolar epithelial cells play a central role in the repair process. They ar...

journal_title：American journal of respiratory cell and molecular biology

authors： Hasegawa T,Sorensen L,Dohi M,Rao NV,Hoidal JR,Marshall BC

更新日期：1997-06-01 00:00:00

abstract：:Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of inflammation, whereas proinflammatory cyt...

journal_title：American journal of respiratory cell and molecular biology

authors： Barnes PJ

更新日期：2009-12-01 00:00:00

abstract：:Eotaxins-1, -2, and -3 mediate the recruitment of blood-borne eosinophils to allergically inflamed tissues by binding CC chemokine receptor (CCR) 3. Mast cells (MCs) are resident tissue cells that also express CCR3. In the present study, we demonstrate that human (h) MCs in nasal polyps and cultured cord blood-derived...

journal_title：American journal of respiratory cell and molecular biology

authors： Price KS,Friend DS,Mellor EA,De Jesus N,Watts GF,Boyce JA

更新日期：2003-04-01 00:00:00

abstract：:Glucose moves into airway secretions after a glucose load. Therefore people with diabetes or hyperglycemia spend a significant proportion of each day with glucose in their airways secretions. This study investigated the effects of glucose on isolated human airways and on cultured airway smooth muscle (ASM) cells. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Cazzola M,Calzetta L,Rogliani P,Lauro D,Novelli L,Page CP,Kanabar V,Matera MG

更新日期：2012-10-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a potent contractile agonist in guinea pig peripheral lung strips. Whether PAF acts via specific receptor sites in the lung has not been fully established. To determine if specific receptor sites could be demonstrated in guinea pig peripheral lung tissue, we performed direct radioli...

journal_title：American journal of respiratory cell and molecular biology

authors： Gomez J,Bloom JW,Yamamura HI,Halonen M

更新日期：1990-09-01 00:00:00

abstract：:Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood ...

journal_title：American journal of respiratory cell and molecular biology

authors： Klut ME,Doerschuk CM,Van Eeden SF,Burns AR,Hogg JC

更新日期：1993-07-01 00:00:00

abstract：:The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan (HMW-HA), typical of uninflamed tissues, is known to suppress inflammation. We investigated whether HMW-H...

journal_title：American journal of respiratory cell and molecular biology

authors： Gebe JA,Yadava K,Ruppert SM,Marshall P,Hill P,Falk BA,Sweere JM,Han H,Kaber G,Harten IA,Medina C,Mikecz K,Ziegler SF,Balaji S,Keswani SG,Perez VA,Butte MJ,Nadeau K,Altemeier WA,Fanger N,Bollyky PL

更新日期：2017-01-01 00:00:00

abstract：:Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is this more true than in the elucidation and verification of the pathogenetic basis upon which they develop. Scientific progress, most recently in the field of experimental therapy, has relied closely on interpreting data derived fr...

journal_title：American journal of respiratory cell and molecular biology

authors： Chua F,Gauldie J,Laurent GJ

更新日期：2005-07-01 00:00:00

abstract：:To reach the sites of inflammation, neutrophils traverse the endothelium, its underlying basement membrane, and other barriers depending on the localization of the insulting agent. Whether neutrophil elastase (NE) plays a role in neutrophil recruitment to inflamed sites is still debatable. By exploiting mice deficient...

journal_title：American journal of respiratory cell and molecular biology

authors： Hirche TO,Atkinson JJ,Bahr S,Belaaouaj A

更新日期：2004-04-01 00:00:00

abstract：:The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we sought to investigate the role of the mTOR pathway in lung epithelia...

journal_title：American journal of respiratory cell and molecular biology

authors： Saito M,Mitani A,Ishimori T,Miyashita N,Isago H,Mikami Y,Noguchi S,Tarui M,Nagase T

更新日期：2020-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is an important inflammatory mediator produced by activated monocytes and macrophages. We have previously shown that porcine alveolar macrophages (PAM) mediate bystander cytotoxicity through hydrogen peroxide production following activation with immobilized IgG immune complex (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JW,Wierda WG,Kim YB

更新日期：1991-09-01 00:00:00