Abstract:
:Aim of this study was to evaluate the responsiveness of red mullet (Mullus barbatus) liver detoxification enzymes to PAHs at transcriptional and post-transcriptional levels in the field. Fish were captured in the north-eastern Adriatic Sea, close to an oil refinery. Sixteen PAHs (EPA) were determined in sediments and fish fillets; transcription levels of cyp1a, cyp3a and abcc2 genes and EROD, BROD, B(a)PMO, BFCOD, GST and UDPGT enzymatic activities were measured. Levels of PAHs in sediments reflect the oil pollution gradient of the area, with weak correspondence in fish fillets. cyp1a gene transcription and EROD, B(a)PMO and BFCOD activities were significantly induced in the oil refinery site, and a slight up-regulation of cyp3a and abcc2 was also observed. GST and UDPGT remained unchanged. The present study provides the first data on detoxification responses at transcriptional levels in the liver of red mullet and confirms phase I enzymes as suitable biomarkers of exposure to PAHs in field studies.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Della Torre C,Corsi I,Nardi F,Perra G,Tomasino MP,Focardi Sdoi
10.1016/j.marenvres.2010.03.009subject
Has Abstractpub_date
2010-07-01 00:00:00pages
95-101issue
1eissn
0141-1136issn
1879-0291pii
S0141-1136(10)00049-8journal_volume
70pub_type
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journal_title:Marine environmental research
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journal_title:Marine environmental research
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2016.06.003
更新日期:2016-08-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2012.06.005
更新日期:2012-08-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.marenvres.2011.09.015
更新日期:2012-05-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2004.10.007
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/s0141-1136(00)00130-6
更新日期:2000-07-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2012.12.003
更新日期:2013-03-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
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journal_title:Marine environmental research
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journal_title:Marine environmental research
pub_type: 杂志文章
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journal_title:Marine environmental research
pub_type: 杂志文章
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journal_title:Marine environmental research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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