Cytomegalovirus ventriculoencephalitis after unrelated double cord blood stem cell transplantation with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.

Abstract:

:Despite the prophylaxis and preemptive strategies using potent antiviral agents, cytomegalovirus (CMV) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation (SCT) recipients. Delayed immune reconstitution after SCT, such as cord blood and T-cell depleted SCT with the use of alemtuzumab, has been associated with an increased frequency of CMV disease as well as CMV reactivation. CMV disease involving central nervous system is an unusual presentation in the setting of SCT. We report a case of CMV ventriculoencephalitis after unrelated double cord blood SCT with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.

journal_name

J Korean Med Sci

authors

Lee S,Kim SH,Choi SM,Lee DG,Kim SY,Lee JW,Min WS,Shin WS,Kim CC

doi

10.3346/jkms.2010.25.4.630

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

630-3

issue

4

eissn

1011-8934

issn

1598-6357

journal_volume

25

pub_type

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