Abstract:
:Recent studies have demonstrated that total cellular levels of voltage-gated potassium channel subunits can change on a time scale of minutes in acute slices and cultured neurons, raising the possibility that rapid changes in the abundance of channel proteins contribute to experience-dependent plasticity in vivo. In order to investigate this possibility, we took advantage of the medial nucleus of the trapezoid body (MNTB) sound localization circuit, which contains neurons that precisely phase-lock their action potentials to rapid temporal fluctuations in the acoustic waveform. Previous work has demonstrated that the ability of these neurons to follow high-frequency stimuli depends critically upon whether they express adequate amounts of the potassium channel subunit Kv3.1. To test the hypothesis that net amounts of Kv3.1 protein would be rapidly upregulated when animals are exposed to sounds that require high frequency firing for accurate encoding, we briefly exposed adult rats to acoustic environments that varied according to carrier frequency and amplitude modulation (AM) rate. Using an antibody directed at the cytoplasmic C-terminus of Kv3.1b (the adult splice isoform of Kv3.1), we found that total cellular levels of Kv3.1b protein-as well as the tonotopic distribution of Kv3.1b-labeled cells-was significantly altered following 30 min of exposure to rapidly modulated (400 Hz) sounds relative to slowly modulated (0-40 Hz, 60 Hz) sounds. These results provide direct evidence that net amounts of Kv3.1b protein can change on a time scale of minutes in response to stimulus-driven synaptic activity, permitting auditory neurons to actively adapt their complement of ion channels to changes in the acoustic environment.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Strumbos JG,Polley DB,Kaczmarek LKdoi
10.1016/j.neuroscience.2010.02.046subject
Has Abstractpub_date
2010-05-19 00:00:00pages
567-72issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(10)00274-5journal_volume
167pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::A small surgical lesion of the parietal cortex induces an increase in the expression of several messenger RNAs varying from 172 to 980% in the entire homolateral cerebral cortex, as detected by quantitative in situ hybridization histochemistry. The messenger RNAs encoding the immediate early genes of the leucine zippe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90287-9
更新日期:1994-04-01 00:00:00
abstract::Studies in humans have documented that acute acid infusion into the esophagus leads to decrease in threshold for sensations to mechanical distension of the esophagus. It is not known whether acid infusion leads to sensitization of brainstem neurons receiving synaptic input from vagal afferent fibers innervating the es...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.07.016
更新日期:2005-01-01 00:00:00
abstract::The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. In six cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was either (a) ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90120-6
更新日期:1989-01-01 00:00:00
abstract::Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.05.039
更新日期:2011-08-25 00:00:00
abstract::Studies with animal seizure models have indicated that changes in temporal and spatial expression of voltage-gated sodium channels may be important in the pathology of epilepsy. Here, by using in situ hybridisation with previously characterised subtype-selective oligonucleotide probes [Whitaker et al. (2000) J. Comp. ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00212-3
更新日期:2001-01-01 00:00:00
abstract:UNLABELLED:GABA is an important inhibitory transmitter in the CNS. In the enteric nervous system, however, both excitatory and inhibitory actions have been reported. Here, we investigated the effects of GABA on the intracellular Ca2+ concentration of guinea-pig myenteric neurons (at 35 degrees C) using Fura-2-AM. Neuro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.12.023
更新日期:2006-05-12 00:00:00
abstract::Using spinal cord and dorsal root ganglion cell cultures, we have studied the immuno-histochemical distribution of several peptide products of the dynorphin gene. With antibody directed toward the midregion of dynorphin A, peptide-immunoreactivity was found exclusively in the cell bodies of spinal cord neurons. Antibo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90110-7
更新日期:1986-08-01 00:00:00
abstract::Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.09.019
更新日期:2016-11-19 00:00:00
abstract::The efferent connections of the thalamic nucleus dorsointermedius posterior were studied in the pigeon. In pigeons, this thalamic nucleus receives both paleostriatal (basal ganglia) and cerebellar input and has been compared to nuclei of the mammalian thalamic ventral tier on this basis. The present results show that ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(82)90097-5
更新日期:1982-01-01 00:00:00
abstract::While systemic capsaicin in adult rats is known to reduce substance P and somatostatin in primary sensory nerves, it is still unknown if it also affects the production of these peptides at the genetic level. Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprot...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00334-x
更新日期:1997-01-01 00:00:00
abstract::In several neurological disorders including hyperhomocysteinemia, homocysteine (Hcy) accumulates in the brain, and acts as a potent neurotoxin. However, the molecular mechanisms induced by increased levels of Hcy in brain are not well understood. Here we show an activation of the extracellular signal-regulated kinases...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.03.034
更新日期:2005-01-01 00:00:00
abstract::Neurons depend upon the processes of axonal and transneuronal transport for intra- and intercellular communication and trophic support. Experimental studies in the last decade have elucidated the mechanisms underlying these processes, and provided evidence for their role in the spread of viral and toxic diseases throu...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/0306-4522(87)90063-7
更新日期:1987-11-01 00:00:00
abstract::Considerable evidence suggests that dynorphin participates in the regulation of energy balance. In this study, we have used immunohistochemistry to investigate in detail the cellular localization of pro-dynorphin (DYN) immunoreactive cell bodies in the mediobasal hypothalamus with special reference to neurons producin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.04.011
更新日期:2008-06-26 00:00:00
abstract::Maternal separation (MS) during the first postnatal weeks induces alcohol intake and a reduction in the expression of glucocorticoid receptors (GR). Adults' alcohol consumption may depend on changes in the endocannabinoid system (eCBs). Our goal was to evaluate the status of the eCBs before the exposition to alcohol t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.07.071
更新日期:2012-10-25 00:00:00
abstract::The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90392-1
更新日期:1994-09-01 00:00:00
abstract::Although GABA is the major inhibitory neurotransmitter in adult brain, it exerts depolarizing actions in developing neurons that include activation of voltage-gated calcium channels. The depolarizing actions of GABA serve an obvious trophic function, but the specific physiological significance of excitatory versus inh...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00794-7
更新日期:2003-01-01 00:00:00
abstract::In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90460-x
更新日期:1994-02-01 00:00:00
abstract::Chronic stress, the administration of glucocorticoids and the prolonged activation of glucocorticoid receptors (GRs) are reported to induce affective changes in humans and rodents that resemble a depressive state. However, data concerning the behavioral and molecular effects of the selective activation of specific GRs...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.11.035
更新日期:2015-02-12 00:00:00
abstract::Caffeine works through a variety of complex mechanisms to exert an often bidirectional set of functional and structural neurological changes in vertebrates. We investigated the effects of chronic caffeine exposure on functional recovery of the dorsal light reflex (DLR) in hemilabyrinthectomized common goldfish, Carass...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.02.038
更新日期:2015-04-30 00:00:00
abstract::The present study was designed to assess the possibility that sub-total ventral hippocampal lesions might leave intact a mechanism for only highly accurate navigation, whereas sub-total dorsal hippocampal lesions might leave intact a mechanism only for less precise navigation. Animals with selective dorsal, ventral or...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.05.007
更新日期:2004-01-01 00:00:00
abstract::The acute self-stimulation of the medial forebrain bundle was reported to induce the expression of c-Fos, the protein product of c-fos, an immediate early gene, in the central nervous system. In the present study, we examined regional changes in c-Fos expression in several reward-related areas of rat brain in response...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00510-7
更新日期:1999-03-01 00:00:00
abstract::The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainat...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00469-3
更新日期:2001-01-01 00:00:00
abstract::Physiological (pH 7.2 and 7.0) and pathological (pH 6.8 and 6.6) changes of external pH, as they are measured in vivo, were imposed on mouse astrocytes in primary cultures and the effect on components of K+ transport pathways across the cell membrane was measured. Physiological pH changes had no effect at all. Patholo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90024-8
更新日期:1987-01-01 00:00:00
abstract::Transthyretin is the major thyroxine-binding protein in the plasma of rodents, and the main thyroxine-binding protein in the cerebrospinal fluid of both rodents and humans. The choroid plexus synthesizes transthyretin and secretes it to the cerebrospinal fluid. Although it was suggested that transthyretin might play a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00228-2
更新日期:2002-01-01 00:00:00
abstract::Previous studies have shown oxidative damage resulting from amyloid Abeta exposure to cultured cells and in murine models. A target of oxidation is 14-3-3 which comprises a group of proteins involved in kinase activation and chaperone activity. The present study shows glycoxidative damage, as revealed with mono and bi...
journal_title:Neuroscience
pub_type: 杂志文章,收录出版
doi:10.1016/j.neuroscience.2007.03.013
更新日期:2007-06-08 00:00:00
abstract::Electroconvulsive therapy has been commonly applied in the treatment of refractory depression, but its cognitive side effects are noticed and restrict its application. The molecular mechanisms underlying the side effects remain elusive, and there is no efficient prevention. By employing a recognized electroconvulsive ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.03.060
更新日期:2010-06-30 00:00:00
abstract::Small (SK) and intermediate (IK) conductance calcium-activated potassium channels are candidate ion channels for the regulation of excitability in nociceptive neurones. We have used unique peptide-directed antisera to describe the immunocytochemical distribution of the known isoforms of these ion channels in dorsal ro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.09.062
更新日期:2005-01-01 00:00:00
abstract::The acute behavioural and metabolic consequences of functional changes following unilateral intracaudate kainic acid at the level of the feline caudate nucleus, the substantia nigra pars reticulata and the deeper layers of the colliculus superior were investigated. The present study became possible since it was previo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90240-6
更新日期:1989-01-01 00:00:00
abstract::The neurosensory cells of the primary olfactory and vomeronasal projections are in a state of continuous replacement throughout adult life. Since their axons form synaptic terminals with neurons in the olfactory and accessory olfactory bulbs, this system is an apparent exception to the rule that peripheral axons canno...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90176-9
更新日期:1985-01-01 00:00:00
abstract::GABAB receptors affect short-term signalling in various cell types. However, nothing is known about possible long-term effects on transcription. To analyse such effects in the CNS, we studied GABAB receptor-mediated gene regulation in primary cultures of cerebellar granule neurons. Transcription was followed using a c...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00380-0
更新日期:1996-01-01 00:00:00