当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL RHEUMATOLOGY期刊下所有文献 > Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis.

Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis.

Abstract：

OBJECTIVES:Despite the important role of the transcription factor HIF-1alpha in angiogenesis and inflammation, only a few studies on HIF-1alpha expression have been performed in RA patients. The aim of the present study was to identify the layer in synovial tissue of RA patients where HIF1a is expressed and to find out whether HIF-1alpha expression is related to both angiogenesis and inflammation in synovium from RA patients. METHODS:A reproducible staining method for HIF-1alpha was developed. HIF-1alpha -positive cells were quantified in synovial tissue from patients with RA. As control we used synovial tissue from patients with osteoarthritis (OA). The number of HIF-1alpha-positive cells was compared with the number of blood vessels present and was correlated with the amount of inflammation. The amount of inflammation was determined by counting inflammatory cells, by estimating the proliferation marker Ki67 in inflamed tissue, and by using a recently published synovitis score which gives an accurate estimate of the amount of inflammation present. RESULTS:HIF-1alpha was expressed weakly in the lining layer and strongly in the sublining layer in RA synovial tissue. In contrast, HIF-1alpha was only weakly expressed in OA synovial tissue. The number of HIF-1alpha -positive cells correlated strongly with the number of blood vessels in RA synovial tissue and with inflammatory endothelial cell infiltration (blood vessels), cell proliferation (Ki67) and the synovitis score. CONCLUSIONS:HIF-1alpha expression is strongest in the sub-lining layer of RA synovium and is related to both angiogenesis and inflammation in synovium from RA patients. These results thus suggest that HIF-1alpha could serve as an important new therapeutic target in RA, targeting both angiogenesis and inflammation.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Brouwer E,Gouw AS,Posthumus MD,van Leeuwen MA,Boerboom AL,Bijzet J,Bos R,Limburg PC,Kallenberg CG,Westra J

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

945-51

issue

6

eissn

0392-856X

issn

1593-098X

pii

2845

journal_volume

27

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY文献大全
  • Immunochemical characterization of the cryoglobulins: pathophysiologic implications.

    abstract：:Immunochemical study of the cryoglobulins has produced a classification of three main types which present clinical correlates. With the current standard immunofixation technique the vast majority of cryoglobulins are presently classified as type II. High-resolution immunoelectrophoretic techniques (immunoblotting and ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Merlini G,Zorzoli I,Anesi E,Perfetti V,Marinone G

    更新日期：1995-11-01 00:00:00

  • Does being easily moved to tears as a response to psychological stress reflect response to treatment and the general prognosis in patients with rheumatoid arthritis?

    abstract：OBJECTIVE:Psychological stress affects the condition of patients with rheumatoid arthritis (RA). We evaluated the neuroendocrine and immune responses (NEIRs) in the peripheral blood to psychological stress induced by deep emotion with tears in patients with RA. METHODS:We compared the levels of plasma cortisol and int...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Ishii H,Nagashima M,Tanno M,Nakajima A,Yoshino S

    更新日期：2003-09-01 00:00:00

  • Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis.

    abstract：OBJECTIVES:To determine the protein expression of TNFAIP3 in synovium and to show the capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA) susceptibility, to influence TNFAIP3 gene transcription. METHODS:Immunohistochemistry for TNFAIP3, NF-kB p65 and phosphorylated NF-kB p65 protein expressio...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Elsby LM,Orozco G,Denton J,Worthington J,Ray DW,Donn RP

    更新日期：2010-09-01 00:00:00

  • Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography.

    abstract：OBJECTIVES:Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. However, there are still no direct da...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Casale R,Boccia G,Symeonidou Z,Atzeni F,Batticciotto A,Salaffi F,Sarzi-Puttini P,Brustio PR,Rainoldi A

    更新日期：2019-01-01 00:00:00

  • A report on the First International Workshop for Lupus Anticoagulant Identification.

    abstract：:Recognition that the lupus anticoagulant (LA) is associated with an increased risk for arterial and venous thrombosis, recurrent spontaneous abortions and fetal loss has led to increased laboratory requests for identification of LA. It is of interest not only to laboratory medicine and obstetrics but also to rheumatol...

    journal_title：Clinical and experimental rheumatology

    pub_type：

    doi：

    authors： Barna LK,Triplett DA

    更新日期：1991-11-01 00:00:00

  • Homing and efficacy of intra-articular injection of autologous mesenchymal stem cells in experimental chondral defects in dogs.

    abstract：OBJECTIVES:This study was intended to verify the likelihood of homing of intra-articularily injected mesenchymal stem cells (MSCs) and its involvement in the healing process of experimentally induced, acute and chronic, partial chondral defects in dogs. METHODS:Partial thickness chondral defects were created on the la...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Mokbel A,El-Tookhy O,Shamaa AA,Sabry D,Rashed L,Mostafa A

    更新日期：2011-03-01 00:00:00

  • Unilateral headaches and their relationship with cervicogenic headache.

    abstract：:The concept of headache originating/starting in the neck is revised and considered in the light of previous descriptions of syndromes and entities and with reference to the current diagnostic systems for the classification of headache and other head pain. Cervicogenic headache (CEH), a clinical picture recently descri...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Bono G,Antonaci F,Dario A,Clerici AM,Ghirmai S,Nappi G

    更新日期：2000-03-01 00:00:00

  • The ultrasound compression sign to diagnose temporal giant cell arteritis shows an excellent interobserver agreement.

    abstract：OBJECTIVES:To compare the diagnostic performance between a vascular specialist and a rheumatologist not familiar with vascular ultrasound when applying the compression sign for the diagnosis of temporal arteritis. METHODS:Sixty consecutive patients with suspicion of giant cell arteritis were examined by both examiners...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Aschwanden M,Imfeld S,Staub D,Baldi T,Walker UA,Berger CT,Hess C,Daikeler T

    更新日期：2015-03-01 00:00:00

  • Protracted febrile myalgia of familial Mediterranean fever.

    abstract：:Protracted febrile myalgia (PFM) includes severe myalgia of the upper and lower extermities accompanied by fever lasting up to 6 weeks, an elevated erythrocyte sedimentation rate and leucucytosis. We report a 13-year-old girl with PFM, and discuss the magnetic resonance imaging findings of the involved calf muscles. T...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Kotevoglu N,Sahin F,Ozkiris SO,Bankaoglu M,Sakiz D,Kuran B

    更新日期：2004-07-01 00:00:00

  • Use of contrast-enhanced magnetic resonance imaging of the pelvis to describe changes at different anatomic sites which are potentially specific for polymyalgia rheumatica.

    abstract：OBJECTIVES:To identify inflammatory pelvic structures of patients with polymyalgia rheumatica (PMR) by magnetic resonance imaging (MRI) in detail, searching for a disease-specific pattern. METHODS:A total of 40 contrast-enhanced pelvic MRIs of patients with a clinical diagnosis of PMR was reviewed by an experienced mu...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Fruth M,Buehring B,Baraliakos X,Braun J

    更新日期：2018-09-01 00:00:00

  • Risk of hospitalisation for serious bacterial infections in patients with rheumatoid arthritis treated with biologics. Analysis from the RECord linkage On Rheumatic Disease study of the Italian Society for Rheumatology.

    abstract：OBJECTIVES:The aims of this study were to define the risk of serious bacterial infections in patients receiving specific biological disease-modifying anti-rheumatic drugs (bDMARDs) and evaluating the effect of concomitant synthetic DMARDs (sDMARDs) in a large population-based sample of rheumatoid arthritis (RA) derivin...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Carrara G,Bortoluzzi A,Sakellariou G,Silvagni E,Zanetti A,Govoni M,Scirè CA

    更新日期：2019-01-01 00:00:00

  • Brazil Patient Knowledge Questionnaire (PKQ) and evaluation of disease-specific knowledge in patients with rheumatoid arthritis.

    abstract：OBJECTIVE:To create a Brazilian version of the Patient Knowledge Questionnaire--PKQ, an instrument for measuring the knowledge of patients with rheumatoid arthritis (RA) as regards their disease, and through the use of this instrument, also measure the knowledge of RA patients from reference hospitals in the city of Sã...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Jennings F,Toffolo S,de Assis MR,Natour J

    更新日期：2006-09-01 00:00:00

  • TNF-α inhibitors reduce inflammation-induced concentric remodelling, but not diastolic dysfunction in collagen-induced arthritis.

    abstract：OBJECTIVES:To determine biologic disease-modifying anti-rheumatic drug effects on inflammation-induced cardiac geometry and function changes. METHODS:Male and female Sprague-Dawley rats (n=92) were divided into four groups: control group, collagen-induced arthritis (CIA) group, anti-TNF-α group and anti-IL-6 group. In...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Le Roux R,Mokotedi L,Fourie S,Manilall A,Gunter S,Millen AME

    更新日期：2021-01-11 00:00:00

  • Etanercept in spondyloarthropathies. Part I: current evidence of efficacy.

    abstract：:Etanercept is a recombinant soluble tumour necrosis factor alpha receptor administered subcutaneously at the dose of 50 mg weekly (or 25 mg/twice weekly) for the treatment of the main chronic arthritides: rheumatoid arthritis and spondyloarthropathies. It shows high qualities in terms of efficacy and manageability. Fa...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Palazzi C,D'Angelo S,Cantini F,Lubrano E,Marchesoni A,Mathieu A,Salvarani C,Scarpa R,Spadaro A,Olivieri I

    更新日期：2011-09-01 00:00:00

  • Tenosynovitis due to Mycobacterium avium-intracellulare: case report and a review of the literature.

    abstract：:A 57-year-old female patient presented with a tenosynovitis due to Mycobacterium avium-intracellulare (MAI). A relapse occurred following surgical treatment, after which she was successfully treated with ansamycin and ethambutol. Previously reported cases of tenosynovitis due to MAI are reviewed and the treatment moda...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Eggelmeijer F,Kroon FP,Zeeman RJ,Dijkmans BA,van 't Wout JW

    更新日期：1992-03-01 00:00:00

  • Glycosaminoglycans in autoimmunity.

    abstract：:Alteration of the distribution pattern and composition of glycosaminoglycans (GAG) and proteoglycans may play an important role in the development of autoimmune diseases. Recent experiments indicate that anti-DNA antibodies cross-reacting with hyaluronic acid, heparan sulphate and chondroitin sulphate are present in p...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Hansen C,Otto E,Kuhlemann K,Förster G,Kahaly GJ

    更新日期：1996-05-01 00:00:00

  • ANCA-positive vasculitis as a secondary autoimmune disease after autologous stem cell transplantation for systemic sclerosis: a case report.

    abstract：:Autologous stem cell transplantation (SCT) is increasingly used to treat autoimmune diseases (AD), in particular systemic sclerosis (SSc). Secondary autoimmune diseases are a known complication after autologous stem cell transplantations for any cause. A 43-year-old man had received an autologous stem cell transplanta...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Schmalzing M,Amann K,Tony HP

    更新日期：2014-11-01 00:00:00

  • A brief history of ultrasound in rheumatology: where are we going.

    abstract：:Musculoskeletal ultrasound is an evolving technique widely used in rheumatology thanks to the numerous advances and the improved work on standardisation. This article deals with the new developments in terms of technology and validation. ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 历史文章,杂志文章,评审

    doi：

    authors： D'Agostino MA,Terslev L

    更新日期：2014-01-01 00:00:00

  • A comparison of the measurement properties and estimation of minimal important differences of the EQ-5D and SF-6D utility measures in patients with systemic sclerosis.

    abstract：OBJECTIVES:To compare measurement properties of the EQ-5D and SF-6D utility measures, to assess the association and agreement between these measures and to estimate minimal important differences (MID) in patients with systemic sclerosis (SSc). METHODS:Both measures were assessed twice in an observational prospective d...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Kwakkenbos L,Fransen J,Vonk MC,Becker ES,Jeurissen M,van den Hoogen FH,van den Ende CH

    更新日期：2013-03-01 00:00:00

  • Osteoarticular infection associated with the human immunodeficiency virus.

    abstract：:An analysis is presented of 20 patients with the human immunodeficiency virus (HIV) infection who were treated for skeletal infection in our hospital. Seventeen cases of septic arthritis and three of osteomyelitis were found. All patients were intravenous drug abusers, 75% were male and all were younger than 40 years ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Muñoz Fernandez S,Quiralte J,del Arco A,Balsa A,Cardenal A,Peña JM,Vazquez JJ,Gijón Baños J

    更新日期：1991-09-01 00:00:00

  • Down regulation of glucocorticoid receptors in early-diagnosed rheumatoid arthritis.

    abstract：OBJECTIVE:In patients with rheumatoid arthritis (RA) of longer duration, glucocorticoid receptor (GR) down-regulation has been reported without any change in cortisol levels. This phenomenon might play a role in the aetio-pathogenesis of RA. Therefore we studied GR expression, as well as the serum cortisol levels, in p...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： van Everdingen AA,Huisman AM,Wenting MJ,van Reesema S,Jacobs JW,Bijlsma JW

    更新日期：2002-07-01 00:00:00

  • Clinical presentation, burden of disease and treatment in young-onset and late-onset rheumatoid arthritis: a matched-pairs analysis taking age and disease duration into account.

    abstract：OBJECTIVES:The aim of this study is to compare clinical features and treatment of young onset rheumatoid arthritis with late-onset rheumatoid arthritis. METHODS:Nine thousand five hundred forty-one patients with rheumatoid arthritis (RA) enrolled in the national database of the German Collaborative Arthritis Centres i...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Huscher D,Sengler C,Gromnica-Ihle E,Bischoff S,Eidner T,Ochs W,Richter J,Zink A

    更新日期：2013-03-01 00:00:00

  • Efficacy of intravenous cyclosporine in a case of cytophagic histiocytic panniculitis complicated by haemophagocytic syndrome after visceral leishmania infection.

    abstract：:Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis characterized by systemic features, due to histiocytic infiltration along with haemophagocytosis, which may also appear in bone marrow, spleen, lymph nodes, and liver. Haemophagocytic lymphohistiocytosis (HLH) is a group of autoinflammatory disorders, wh...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Merelli M,Quartuccio L,Bassetti M,Pecori D,Gandolfo S,Avellini C,De Vita S

    更新日期：2015-11-01 00:00:00

  • Increase of RP105-lacking activated B cells in the peripheral blood and salivary glands in patients with Sjögren's syndrome.

    abstract：OBJECTIVE:To quantify the activated B cells in the peripheral blood and salivary glands of patients with Sjögren's syndrome (SS) by analyzing the expression of RP105 molecule on the B cells. METHODS:The expression of RP105 on the peripheral blood B cells of patients with SS (19 cases) was analyzed by flow cytometry. R...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Kikuchi Y,Koarada S,Nakamura S,Yonemitsu N,Tada Y,Haruta Y,Morito F,Ohta A,Miyake K,Horiuchi T,Nagasawa K

    更新日期：2008-01-01 00:00:00

  • Consideration of coping strategies for patients suffering from systemic lupus erythematosus: reflection for a personalised practice of patient education.

    abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a chronic autoimmune multi-organ disease with an unpredictable course. SLE causes functional disability, changes in body appearance, and psychological distress. When faced with SLE, patients have to implement coping strategies. Therefore, the aim of this study was to des...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Farhat MM,Morell-Dubois S,Le Gouellec N,Launay D,Maillard H,Balquet MH,Azar R,Quemeneur T,Boldron A,Bataille P,Lambert M,Lanteri A,Buchdahl AL,Sobanski V,Hatron PY,Hachulla E,Clerson P,ESSTIM Investigators group.

    更新日期：2020-07-01 00:00:00

  • Necrotising myopathy associated with anti-signal recognition particle (anti-SRP) antibody.

    abstract：OBJECTIVES:Prompted by the few studies available in the literature, we analysed patients with necrotising myopathy associated with anti-signal recognition particle (anti-SRP). METHODS:We conducted a retrospective, single-centre cohort study involving 14 patients with anti-SRP antibody followed between 2001 and 2016. ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： De Souza FHC,Miossi R,Shinjo SK

    更新日期：2017-09-01 00:00:00

  • Psychological side effects of MTX treatment in juvenile idiopathic arthritis: a pilot study.

    abstract：OBJECTIVE:To document the psychological side effects of methotrexate (MTX) treatment in children with juvenile idiopathic arthritis (JIA) and to explore the usefulness of psychological therapy to ameliorate these side effects. METHODS:The patients included in this study consisted of 29 patients with JIA using MTX. Of ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 临床试验,杂志文章

    doi：

    authors： van der Meer A,Wulffraat NM,Prakken BJ,Gijsbers B,Rademaker CM,Sinnema G

    更新日期：2007-05-01 00:00:00

  • A working classification of scleroderma spectrum disorders: a proposal and the results of testing on a sample of patients.

    abstract：OBJECTIVE:To propose a working classification for scleroderma spectrum disorders (SDS), based on criteria shown in the past to be specific for the condition: sclerodermatous skin involvement, specific autoantibodies and specific microvascular abnormalities, to obtain mutually exclusive subgroups of SDS and to test this...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Maricq HR,Valter I

    更新日期：2004-01-01 00:00:00

  • Pulmonary involvement in patients with childhood-onset systemic lupus erythematosus.

    abstract：OBJECTIVE:Pulmonary involvement is a common finding in adults with systemic lupus erythematosus (SLE). The aim of this study was to investigate the frequency of pulmonary abnormalities in patients with childhood-onset SLE, with particular reference to interstitial lung disease (ILD), and to examine any association betw...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Lilleby V,Aaløkken TM,Johansen B,Førre Ø

    更新日期：2006-03-01 00:00:00

  • Behçet's syndrome: a critical digest of the recent literature.

    abstract：:A similar disease severity among men and women in Brasil, a high frequency of gastrointestinal involvement in China, Japan and USA, a low frequency of pathergy positivity in Japan and USA underline the ethnic variations reported in recent studies. Polymorphisms pertaining both to innate and adaptive immunity in genome...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Hatemi G,Seyahi E,Fresko I,Hamuryudan V

    更新日期：2012-05-01 00:00:00