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Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke.

Abstract：

:The hippocampus is often injured in neonatal stroke. We have investigated the effect of erythropoietin (EPO) on oxygen-glucose deprived hippocampal slices and hypoxic progenitor cells. EPO improved survival of the organotypic hippocampal slices with significantly less cell death in the dentate gyrus and an increased number of proliferating cells 4-5 days after insult. Significantly fewer markers of neurogenesis were seen after the insult but when EPO was added to the culture medium, neurogenesis was sustained. When hippocampal progenitor cultures were stimulated into differentiation, more cells chose a neuronal cell fate when treated with EPO. These findings support the hypothesis that EPO not only prevents ischemia induced cell death but promotes neuronal cell fate commitment in in vitro models of neonatal stroke.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Osredkar D,Sall JW,Bickler PE,Ferriero DM

doi

10.1016/j.nbd.2010.01.015

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

259-65

issue

2

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(10)00031-8

journal_volume

38

pub_type

杂志文章

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