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Dual response of BDNF to sublethal concentrations of beta-amyloid peptides in cultured cortical neurons.

Abstract：

:Beta-amyloid (Abeta) deposition is one important pathological hallmark in Alzheimer's disease (AD). However, low levels of Abeta may modify critical endogenous protection systems before neurodegeneration occurs. We examined the time-course effect of sublethal concentrations of Abeta on total BDNF (panBDNF), BDNF transcripts (I, II, IV and VI), trkB.FL, trkB.T1 and p75(NGFR) mRNA expression in cultured cortical neurons. We have shown that Abeta exhibited a dual response on BDNF mRNA, i.e. an increase at short times (3-5 h) and a dramatic decrease at longer times (24 or 48 h). The early increase in BDNF expression seems to be driven by increased expression of transcripts I and IV. The BDNF drop was specific since did not occur for other mRNAs examined. The BDNF protein content showed a similar profile but did not follow the dramatic reduction as its encoding mRNA. These observations may help to explain cognitive deficits observed at initial stages of AD.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Aliaga E,Silhol M,Bonneau N,Maurice T,Arancibia S,Tapia-Arancibia L

doi

10.1016/j.nbd.2009.10.004

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

208-17

issue

1

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(09)00281-2

journal_volume

37

pub_type

杂志文章

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